DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG13344 and RNF25

DIOPT Version :9

Sequence 1:NP_001027416.2 Gene:CG13344 / 36541 FlyBaseID:FBgn0033884 Length:374 Species:Drosophila melanogaster
Sequence 2:NP_071898.2 Gene:RNF25 / 64320 HGNCID:14662 Length:459 Species:Homo sapiens


Alignment Length:350 Identity:109/350 - (31%)
Similarity:174/350 - (49%) Gaps:37/350 - (10%)


- Green bases have known domain annotations that are detailed below.


  Fly     4 LQDEVESLEAILMDDV-CIKRTPSGEVEQIETTVLPLTGEEEEQQYVCVTLQVHPTPGYPEESPT 67
            |..|||.||:|.:|:: .||........:|..|:.|.|.|:::.||||.||.:.....||.|.|.
Human    16 LPSEVEVLESIYLDELQVIKGNGRTSPWEIYITLHPATAEDQDSQYVCFTLVLQVPAEYPHEVPQ 80

  Fly    68 FKLLRPRGLDDARLEAIRSACNAKIKESIGFPVVFDLIEVVREHLSGSNLPSGQCVVCLYGFADG 132
            ..:..||||.|.::..|........|..:|..::::|||..:|.|:.:|:|.||||:|||||.:.
Human    81 ISIRNPRGLSDEQIHTILQVLGHVAKAGLGTAMLYELIEKGKEILTDNNIPHGQCVICLYGFQEK 145

  Fly   133 DEFTRTECFHYLHSYCLARHLNALR-----RNYQEEFDKLPAWLQKTADPFQALCPVCREHIGDE 192
            :.||:|.|:||.|.:||||::..:.     :..::|.::..|..::.|...|  ||||||.:..:
Human   146 EAFTKTPCYHYFHCHCLARYIQHMEQELKAQGQEQEQERQHATTKQKAVGVQ--CPVCREPLVYD 208

  Fly   193 TDSLKCAMPPSELLNAPEFKVTEELRQMQQRMSELYLQQKSRGAIIDVNAEGSA-VISI------ 250
            ..|||.|..|.:.:...: ...|.|||.::| ..||.:|:.||.|||:.||.:. .||:      
Human   209 LASLKAAPEPQQPMELYQ-PSAESLRQQEER-KRLYQRQQERGGIIDLEAERNRYFISLQQPPAP 271

  Fly   251 ---ETEEDIRRRRRREEAEAAKKLEGPSKEEVIKPTTSSTFAPVVQ-------------ETHRIM 299
               |:..|:.:..:.....||:....|:.:..:.|........:.:             ||.:.|
Human   272 AEPESAVDVSKGSQPPSTLAAELSTSPAVQSTLPPPLPVATQHICEKIPGTRSNQQRLGETQKAM 336

  Fly   300 ---PEPTNNNYHH-NRRHYRGGRRH 320
               |:|:...:.. .|||.:||..|
Human   337 LDPPKPSRGPWRQPERRHPKGGECH 361

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG13344NP_001027416.2 RWD 7..115 CDD:214735 37/108 (34%)
zf-RING_2 120..186 CDD:290367 27/70 (39%)
RNF25NP_071898.2 RWD 19..128 CDD:214735 37/108 (34%)
RING-H2_RNF25 134..203 CDD:319384 27/70 (39%)
RING-H2 finger (C3H2C3-type) 135..201 CDD:319384 24/67 (36%)
Atrophin-1 <264..445 CDD:331285 17/97 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 268..309 6/40 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 322..459 10/39 (26%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165159908
Domainoid 1 1.000 101 1.000 Domainoid score I6990
eggNOG 1 0.900 - - E1_KOG4445
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 161 1.000 Inparanoid score I4229
Isobase 1 0.950 - 0 Normalized mean entropy S6720
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D294594at33208
OrthoFinder 1 1.000 - - FOG0006434
OrthoInspector 1 1.000 - - oto90841
orthoMCL 1 0.900 - - OOG6_106454
Panther 1 1.100 - - LDO PTHR13198
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4877
SonicParanoid 1 1.000 - - X5392
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1514.740

Return to query results.
Submit another query.