DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG13344 and Rnf25

DIOPT Version :9

Sequence 1:	NP_001027416.2	Gene:	CG13344 / 36541	FlyBaseID:	FBgn0033884	Length:	374	Species:	Drosophila melanogaster
Sequence 2:	NP_067288.2	Gene:	Rnf25 / 57751	MGIID:	1890215	Length:	456	Species:	Mus musculus

Alignment Length:	344	Identity:	106/344 - (30%)
Similarity:	176/344 - (51%)	Gaps:	34/344 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LQDEVESLEAILMDDVCIKRTPSGEVEQIETTVLPLTGEEEEQQYVCVTLQVHPTPGYPEESPTF 68
            |..|||.||:|.:|::.:.:.......:|..|:.|.|.|.::.|:||.||.:.....||.|.|..
Mouse    16 LPSEVEVLESIYLDELQVMKGNGRSPWEIFITLHPATAEVQDSQFVCFTLVLRIPVQYPHEVPQI 80

  Fly    69 KLLRPRGLDDARLEAIRSACNAKIKESIGFPVVFDLIEVVREHLSGSNLPSGQCVVCLYGFADGD 133
            .:..||||.|.::..|..|.....||.:|..::::|||..:|.|:.:|:|.||||:|||||.:.:
Mouse    81 SIRNPRGLSDEQIHKISQALGHVAKEGLGTAMLYELIEKGKEILTDNNIPHGQCVICLYGFQEKE 145

  Fly   134 EFTRTECFHYLHSYCLARHLNALRR---NYQEEFDKLPAWLQKTADPFQALCPVCREHIGDETDS 195
            .||:|.|:||.|.:||||::..:.:   ..::|.::.....::.|...|  ||||||.:..:..|
Mouse   146 AFTKTPCYHYFHCHCLARYIQHMEQELTTQEQEQERQHVVTKQKAVGVQ--CPVCREPLVYDLAS 208

  Fly   196 LKCAMPPSELLNAPEFKVTEELRQMQQRMSELYLQQKSRGAIIDVNAEGS----------AVISI 250
            ||.|..|.:.:...: ...|.||| |:.:..||.:|:.:|.|||:.||.:          |.:..
Mouse   209 LKAAPEPQQPMELYQ-PSAESLRQ-QEELKLLYQRQQEKGGIIDLEAERNRYFISLQQPPAALEP 271

  Fly   251 ETEEDIRRRRRREEAEAAKKLEGPSKEEVIKP----TTSSTF------APVVQ---ETHRIMPEP 302
            |:..|:.|..:...|.:|::....:.:..:..    ||..|:      .|..|   ||.:.:.:|
Mouse   272 ESAVDVSREPQPPNALSAEQSTSLADQSTLPTSLPMTTQYTYEKTSGAGPNQQRPGETQKSVLDP 336

  Fly   303 TNNN----YHHNRRHYRGG 317
            ..:.    ..::|||.:||
Mouse   337 PRHGRGSWRQYDRRHPKGG 355

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG13344	NP_001027416.2	RWD	7..115	CDD:214735	36/107 (34%)
CG13344	NP_001027416.2	zf-RING_2	120..186	CDD:290367	26/68 (38%)
Rnf25	NP_067288.2	RWD	19..127	CDD:214735	36/107 (34%)
		zf-RING_2	132..199	CDD:290367	26/68 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	269..456		18/87 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167850279
Domainoid	1	1.000	98	1.000	Domainoid score	I7192
eggNOG	1	0.900	-	-		E1_KOG4445
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	161	1.000	Inparanoid score	I4218
Isobase	1	0.950	-	0	Normalized mean entropy	S6720
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006434
OrthoInspector	1	1.000	-	-		oto94424
orthoMCL	1	0.900	-	-		OOG6_106454
Panther	1	1.100	-	-	LDO	PTHR13198
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4877
SonicParanoid	1	1.000	-	-		X5392
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.730