DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG13344 and rnf25

DIOPT Version :9

Sequence 1:	NP_001027416.2	Gene:	CG13344 / 36541	FlyBaseID:	FBgn0033884	Length:	374	Species:	Drosophila melanogaster
Sequence 2:	NP_957477.1	Gene:	rnf25 / 100003846	ZFINID:	ZDB-GENE-040426-1581	Length:	513	Species:	Danio rerio

Alignment Length:	375	Identity:	103/375 - (27%)
Similarity:	169/375 - (45%)	Gaps:	40/375 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 EVESLEAILMDDVCIKRTPSGEVEQIETTVLPLTGEEEEQQYVCVTLQVHPTPGYPEESPTFKLL 71
            |:|.|::|.:|::.:.:...|. ..:...:.|.|.|:...|:|.:||.:.....||..||...:.
Zfish    10 EIEVLQSIYLDELNVTQNDEGG-WTVSLVLHPSTAEDCLSQFVRLTLTMDLDSQYPYSSPYISIH 73

  Fly    72 RPRGLDDARLEAIRSACNAKIKESIGFPVVFDLIEVVREHLSGSNLPSGQCVVCLYGFADGDEFT 136
            .||||.|.:|.:::.:...:.:|.:|.||::.|||..:|.|:.||:|.|.||:|||.|.:|:.||
Zfish    74 NPRGLSDDKLLSLQKSLQMEAEECVGTPVLYQLIERAKEILTDSNIPHGNCVICLYDFKEGEVFT 138

  Fly   137 RTECFHYLHSYCLARHLNALRRNYQEEFDKLPAWLQKTAD-----PFQALCPVCREHIGDETDSL 196
            :|.|:||.||:||.|::.......::...:|..  .||.|     ....:||||||.:..:.|:|
Zfish   139 KTSCYHYFHSHCLGRYITHSEMELKDRERELEE--DKTRDRTEEEELAVVCPVCRESLTYDLDAL 201

  Fly   197 KCAMPPSELLNAPEFKVTEELRQMQQRMSELYLQQKSRGAIIDVNAEGSA-VISIETEEDIRRRR 260
             .:.|...|....:..:..|.::..:.:.::..:||.:|.:||..||.:. :|.|.
Zfish   202 -LSSPAPVLCQQEDAVIGGEFKKKWEALQKILERQKEKGGVIDPEAESNRFLIHIN--------- 256

  Fly   261 RREEAEAAKKLEGPSKEEVIKPTTSSTFAPVVQETHRIMPEPTNNNYHHNRRHYRGGRRHHHHHQ 325
                       |.|.........|.|:.|...|......|:.|:.......:|..|..:..|
Zfish   257 -----------EAPVNLSDTPGMTDSSGAESTQSLPSSSPDSTSTIQTSQNQHTAGQPQRKH--- 307

  Fly   326 HGHHHRAERERGEQNAAAA----PANAGGSTSNAVNTNSKQAKAQSASSG 371
            .|...|..|.||......|    ||..|......:.::.   |..||:||
Zfish   308 TGDFKRGRRGRGAGRGGPARHMVPAPGGERLGKHIQSSD---KINSANSG 354

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG13344	NP_001027416.2	RWD	7..115	CDD:214735	32/107 (30%)
CG13344	NP_001027416.2	zf-RING_2	120..186	CDD:290367	26/70 (37%)
rnf25	NP_957477.1	RWD	10..114	CDD:283440	31/104 (30%)
rnf25	NP_957477.1	zf-RING_2	122..191	CDD:290367	26/70 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170596179
Domainoid	1	1.000	57	1.000	Domainoid score	I10937
eggNOG	1	0.900	-	-		E1_KOG4445
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	146	1.000	Inparanoid score	I4407
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D294594at33208
OrthoFinder	1	1.000	-	-		FOG0006434
OrthoInspector	1	1.000	-	-		oto39891
orthoMCL	1	0.900	-	-		OOG6_106454
Panther	1	1.100	-	-	LDO	PTHR13198
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X5392
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	13	12.760