DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Uba3 and Atg7

DIOPT Version :9

Sequence 1:	NP_610913.1	Gene:	Uba3 / 36539	FlyBaseID:	FBgn0263697	Length:	450	Species:	Drosophila melanogaster
Sequence 2:	NP_001240646.1	Gene:	Atg7 / 74244	MGIID:	1921494	Length:	741	Species:	Mus musculus

Alignment Length:	376	Identity:	80/376 - (21%)
Similarity:	130/376 - (34%)	Gaps:	117/376 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 LQTKCQVLIIGAGGLGCELLKDLALMGFGNLHV--IDMDTIELSNLNRQFLFRRTDI---GASKA 104
            :..||  |::|||.|||.:.:  .|||:|..||  :|...|..||..||.|:...|.   |..||
Mouse   393 VSVKC--LLLGAGTLGCNVAR--TLMGWGVRHVTFVDNAKISYSNPVRQPLYEFEDCLGGGKPKA 453

  Fly   105 ECA------------ARFINARVPTCRVTPHFKKI------QDFDESFYQQF---HLVVCGLDSI 148
            ..|            ||..|..:|......:|..:      :|.::  .:|.   |.|:..|...
Mouse   454 LAAAERLQKIFPGVNARGFNMSIPMPGHPVNFSDVTMEQARRDVEQ--LEQLIDNHDVIFLLMDT 516

  Fly   149 VARRW-------------INGML-----------LSMLRYEEDGTIDTSSIVPMIDGGTEGFKGN 189
            ...||             ||..|           |...:.:..|.:..|.:|...|.|:..|..
Mouse   517 RESRWLPTVIAASKRKLVINAALGFDTFVVMRHGLKKPKQQGAGDLCPSHLVAPADLGSSLFAN- 580

  Fly   190 ARVILPGF-TACIEC-------------TLDLFPPQVNYPLCTIANTPRLP----EHCIEYVKII 236
                :||: ..|..|             |||        ..||::. |.|.    ...:|.:..:
Mouse   581 ----IPGYKLGCYFCNDVVAPGDSTRDRTLD--------QQCTVSR-PGLAVIAGALAVELMVSV 632

  Fly   237 QWEKQNPFGVPLDGDDPQHIGWIYERALERSNEFNIT-GVTYRLVQGVVK---HIIPAVASTNAA 297
            ....:..:.:....||             |.||...: |:....::|.:.   :::|...:.:.
Mouse   633 LQHPEGGYAIASSSDD-------------RMNEPPTSLGLVPHQIRGFLSRFDNVLPVSLAFDK- 683

  Fly   298 IAAACALEV--------FKLATSCYDSMANYLNFNDLDGIYTYTYEAEKSE 340
             ..||:.:|        |......::|..::|  .||.|:.....|.:.:|
Mouse   684 -CTACSPKVLDQYEREGFTFLAKVFNSSHSFL--EDLTGLTLLHQETQAAE 731

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Uba3	NP_610913.1	ThiF	48..>220	CDD:279270	58/235 (25%)
		Uba3_RUB	50..346	CDD:238765	78/371 (21%)
		E2_bind	357..442	CDD:285976
Atg7	NP_001240646.1	ATG7_N	52..359	CDD:293029
		E1_like_apg7	54..740	CDD:273590	80/376 (21%)
		Apg7	396..720	CDD:238763	77/360 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0476
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900