Protein Alignment Uba3 and Uba5

DIOPT Version :10

• Sequence 1: NP_610913.1
• Gene: Uba3 / 36539
• FlyBaseID: FBgn0263697
• Length: 450
• Species: Drosophila melanogaster
• Sequence 2: NP_079968.2
• Gene: Uba5 / 66663
• MGIID: 1913913
• Length: 403
• Species: Mus musculus
• Alignment Length: 420
• Identity: 82/420 - (19%)
• Similarity: 145/420 - (34%)
• Gaps: 121/420 - (28%)

  Fly    51 VLIIGAGGLGCELLKDLALMGFGNLHVIDMDTIELSNLNRQFLFRRTDIGASKAECAARFI---- 111
            |.|:|.||:|....:.|...|.|.|.:.|.|.:||:|:||.| |:....|.||...|...:
Mouse    74 VAIVGVGGVGSVTAEMLTRCGIGKLLLFDYDKVELANMNRLF-FQPYQAGLSKVHAAEHTLRNIN 137

  Fly   112 --------NARVPTCRVTPHF-KKIQDFDESFYQQFHLVVCGLDSIVARRWINGMLLSM-LRYEE 166
                    |..:.|.....|| .:|.:......|...||:..:|:..||..||.....: ..:.|
Mouse   138 PDVLFEVHNYNITTVEHFEHFMNRISNGGLEEGQPVDLVLSCVDNFEARMAINTACNELGQTWME 202

  Fly   167 DGTIDTSSIVPMIDGGTEGFKGNARVILPGFTACIECTLDLFPPQVNYPLCTIANTPRLPEHCIE 231
            .|..:.:            ..|:.::::||.:||..|.    ||.|      :|:.
Mouse   203 SGVSENA------------VSGHIQLMIPGESACFACA----PPLV------VASN--------- 236

  Fly   232 YVKIIQWEKQNPFGVPLDGDDPQHIGWIYERALERSNEFNITGVTYRLVQGVVKHIIPAVASTNA 296
                                       |.|:.|:|              :||....:|   :|..
Mouse   237 ---------------------------IDEKTLKR--------------EGVCAASLP---TTMG 257

  Fly   297 AIAAACALEVFKLATSCYDSMANYLNFNDLDGIYTYTYEAEKSENCLACSNTPQPLPIEDPNTTT 361
            .:|......|.|.... :.:::.||.:|.:...:...:            ..|.| ..:|.|...
Mouse   258 VVAGILVQNVLKFLLK-FGTVSFYLGYNAMQDFFPTMF------------MKPNP-QCDDKNCRK 308

  Fly   362 LEDVIKLLCDSPRFQLKSPALTTVMKDGKRRTLYMS-----GVKSIEEATRKNLTQSLGEL-GLH 420
            .::         .::.::.||.|...:.:.....:.     |::.:.|.:.:.|..|.|.: .|.
Mouse   309 QQE---------EYKKRAAALPTQEAEPQEEAEVVHEDNEWGIELVSEVSEEELKNSSGPVPTLP 364

  Fly   421 DGQQL--TVTDATSPSAMTLQLKYQSNEVE 448
            :|..:  ||...|..||..:.::.....:|
Mouse   365 EGITVAYTVPKKTEDSASEVTVEDSGESLE 394

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Uba3	NP_610913.1	Uba3_RUB	50..346	CDD:238765	62/308 (20%)
		E2_bind	357..442	CDD:462611	16/92 (17%)
Uba5	NP_079968.2	ThiF_MoeB_HesA_family	50..293	CDD:238386	62/295 (21%)
		UFM1-interacting sequence (UIS). /evidence=ECO:0000250|UniProtKB:Q9GZZ9	333..345		1/11 (9%)
		Linker. /evidence=ECO:0000250|UniProtKB:Q9GZZ9	346..376		8/29 (28%)
		UFC1-binding sequence (UFC). /evidence=ECO:0000250|UniProtKB:Q9GZZ9	388..403		1/7 (14%)