DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Uba3 and uba2

DIOPT Version :9

Sequence 1:	NP_610913.1	Gene:	Uba3 / 36539	FlyBaseID:	FBgn0263697	Length:	450	Species:	Drosophila melanogaster
Sequence 2:	NP_001017091.1	Gene:	uba2 / 549845	XenbaseID:	XB-GENE-977709	Length:	641	Species:	Xenopus tropicalis

Alignment Length:	568	Identity:	137/568 - (24%)
Similarity:	214/568 - (37%)	Gaps:	191/568 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 AASSENLEFLQTKCQVLIIGAGGLGCELLKDLALMGFGNLHVIDMDTIELSNLNRQFLFRRTDIG 100
            |...|..|.:.|. ::|::||||:||||||:|.|.||.||.|||:|||::|||||||||::..:|
Frog     6 ALPKELAEAVSTS-RLLVVGAGGIGCELLKNLVLTGFINLDVIDLDTIDVSNLNRQFLFQKKHVG 69

  Fly   101 ASKAECAARFINARVPTCRVTPHFKKIQ--DFDESFYQQFHLVVCGLDSIVARRWINGMLLSMLR 163
            .|||:.|...:....|...:|.:...|.  |::..|::||.:|:..||:..||..:|.|.|
Frog    70 RSKAQVAKESVLQFCPEANITAYHDSIMNPDYNVEFFKQFTMVMNALDNNAARNHVNRMCL---- 130

  Fly   164 YEEDGTIDTSSIVPMIDGGTEGFKGNARVILPGFTACIECTLDLFPPQVNYPLCTIANTPRLPEH 228
                     ::.:|:|:.||.|:.|...|:..|.|.|.||...  |.|..:|.|||.|||..|.|
Frog   131 ---------AAGIPLIESGTAGYLGQVTVVKKGVTECYECQPK--PTQKTFPGCTIRNTPSEPIH 184

  Fly   229 CIEYVKII-------------------------------------------------QWEKQNPF 244
            ||.:.|.:                                                 ||.|...:
Frog   185 CIVWAKYLFNQLFGEEDADQEVAPDIADPEAAWDPTQAAERANASNVDGDIKRVSTKQWAKSTGY 249

  Fly   245 G-----------------------------VPL-------------------------------- 248
            .                             |||
Frog   250 DPIKLFNKLFRDDIKYLLTMDRLWRKRKPPVPLEWSSLHNKENCSETQNESSLQGLKDQKVLDVT 314

  Fly   249 ----------------------------DGDDPQHIGWIYERALERSNEFNITGVTYRLVQGVVK 285
                                        |.|||..:.::...|..|.:.|::...:...|:.:..
Frog   315 SCAQLFSKSVETLREQLREKGNGAELVWDKDDPPAMDFVTAAANLRMHIFSMNMKSRFDVKSMAG 379

  Fly   286 HIIPAVASTNAAIAAACALEVFKLATSCYDSMAN-YLNFN-----------DLDGIYTYTYEAEK 338
            :||||:|:|||.|:....||..|:.:...:.... :||..           .||         ..
Frog   380 NIIPAIATTNAVISGLIVLEGLKILSGNTEQCRTVFLNKQPNPRKKLLVPCSLD---------PP 435

  Fly   339 SENCLACSNTPQ---PLPIEDPNTTTLEDVIKLLCDSPRFQLKSPALTTVMKDGKRRTLYMSGVK 400
            :.:|..|:..|:   .|.:.......|:|  |:|  ..:|.:.:|.:.  ::|||...|    :.
Frog   436 NPSCYVCAIKPEVTVKLNVHKVTVQMLQD--KIL--KEKFAMVAPDVQ--IEDGKGTIL----IS 490

  Fly   401 SIEEATRKNLTQSLGELGLHDGQQLTVTDATSPSAMTLQLKYQSNEVE 448
            |....|..|..:.:.|.|:.:..||...|......:.:.:.: |:|:|
Frog   491 SEAGETDANNNRKISEFGIRNSSQLQADDFLQDYTLMINILH-SDEME 537

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Uba3	NP_610913.1	ThiF	48..>220	CDD:279270	69/173 (40%)
		Uba3_RUB	50..346	CDD:238765	109/447 (24%)
		E2_bind	357..442	CDD:285976	18/84 (21%)
uba2	NP_001017091.1	Uba2_SUMO	19..442	CDD:238766	109/446 (24%)
		UBA_e1_thiolCys	179..360	CDD:371150	17/180 (9%)
		UAE_UbL	450..536	CDD:373253	20/96 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	546..641
		UBA2_C	549..636	CDD:374424
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D686413at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920