DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Uba3 and sae1

DIOPT Version :9

Sequence 1:	NP_610913.1	Gene:	Uba3 / 36539	FlyBaseID:	FBgn0263697	Length:	450	Species:	Drosophila melanogaster
Sequence 2:	NP_001002058.1	Gene:	sae1 / 415148	ZFINID:	ZDB-GENE-040625-21	Length:	348	Species:	Danio rerio

Alignment Length:	333	Identity:	67/333 - (20%)
Similarity:	120/333 - (36%)	Gaps:	67/333 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 QVLIIGAGGLGCELLKDLALMGFGNLHVIDMDTIELSNLNRQFLFRRTDIGASKAECA---ARFI 111
            :||::|..|||.|:.|:|.|.|...|.::|.:.:...:...|||......|.:.|:.:   |:|:
Zfish    39 RVLLVGLRGLGAEVAKNLILAGVKGLTLLDHEQVTEESRRAQFLIPVDADGQNHAQASLERAQFL 103

  Fly   112 NARVPTCRVTPHFKKIQDFDESFYQQFHLVV---CG------LDSIVARRWI----------NGM 157
            |   |...|....:.::...:.|:.||..|.   |.      :|.:.|.|.|          ||.
Zfish   104 N---PMVEVKADTEPVESKPDDFFFQFDAVCLTRCSRDLMVRVDQLCASRNIKVFCGDVYGYNGY 165

  Fly   158 LLSMLRYEEDGTIDTSSIVPMIDGGTEGFKGNARVILPGFTACIECTLDLFPPQVNYPLCTIANT 222
            :.|.|..|.....:...:|...:...:|.:.....|.|..|..::.|:.         .|::
Zfish   166 MFSDLGQEYHYVEEKPKVVKGSNEANDGPEAKKPKIDPNETTMVKKTIS---------FCSL--- 218

  Fly   223 PRLPEHCIEYVKIIQW----EKQNPFGVPLD--------------GDDPQHIGWIYERAL---ER 266
                :..:|    :.|    .|.:...:|.|              |.|||...:..:..|   .|
Zfish   219 ----KEALE----VDWTTEKAKSSLKRIPADYFLLQVLLKFRTDKGRDPQPDSFAEDSQLLLQIR 275

  Fly   267 SNEFNITGVTYRLVQGV-VKHIIPAVASTNAAIAAACALEVFKLATSCYDSMANYLNFNDLDGIY 330
            .:.....|::..|:... |.:....::...|.:......|:.|..:.......|:..|:.|.|..
Zfish   276 DDVLETMGLSSDLLPNTFVSYCFSEMSPVCAVVGGVLGQEIVKALSQRDAPHRNFFFFDGLKGSG 340

  Fly   331 TYTYEAEK 338
            ...|.:.|
Zfish   341 VVDYFSSK 348

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Uba3	NP_610913.1	ThiF	48..>220	CDD:279270	44/191 (23%)
		Uba3_RUB	50..346	CDD:238765	67/333 (20%)
		E2_bind	357..442	CDD:285976
sae1	NP_001002058.1	Aos1_SUMO	17..343	CDD:238769	65/326 (20%)
sae1	NP_001002058.1	ThiF	20..>167	CDD:279270	34/130 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0476
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900