Protein Alignment Uba3 and MOCS3

DIOPT Version :10

• Sequence 1: NP_610913.1
• Gene: Uba3 / 36539
• FlyBaseID: FBgn0263697
• Length: 450
• Species: Drosophila melanogaster
• Sequence 2: NP_055299.1
• Gene: MOCS3 / 27304
• HGNCID: 15765
• Length: 460
• Species: Homo sapiens
• Alignment Length: 408
• Identity: 96/408 - (23%)
• Similarity: 132/408 - (32%)
• Gaps: 120/408 - (29%)

  Fly    45 LQTKCQVLIIGAGGLGCELLKDLALMGFGNLHVIDMDTIELSNLNRQFLFRRTDIGASKAECAA- 108
            |.|.| |||:|.|||||.|.:.||..|.|.|.::|.|.:|:|||.||.|......|.:||..||
Human    80 LGTAC-VLIVGCGGLGCPLAQYLAAAGVGRLGLVDYDVVEMSNLARQVLHGEALAGQAKAFSAAA 143

  Fly   109 --RFINARVPTCRVTPHFKKIQDFDESFYQQFHLVVCGLDSIVARRWINGMLLSMLRYEEDGTID 171
              |.:|:.|.....|.........|  ..:::.:|....|::..|..:|...:...|
Human   144 SLRRLNSAVECVPYTQALTPATALD--LVRRYDVVADCSDNVPTRYLVNDACVLAGR-------- 198

  Fly   172 TSSIVPMIDGGTEGFKGNARVILPGFTACIECTLDLFPPQVNYPLCTIANTPRLPEHCIEYVKII 236
                 |::......|:|...|.......|..|.....||......|.
Human   199 -----PLVSASALRFEGQITVYHYDGGPCYRCIFPQPPPAETVTNCA------------------ 240

  Fly   237 QWEKQNPFGVPLDGDDPQHIGWIYERALERSNEFNITGVTYRLVQGVVKHIIPAVASTNAAIAAA 301
                        ||.                            |.|||..::..:.
Human   241 ------------DGG----------------------------VLGVVTGVLGCLQ--------- 256

  Fly   302 CALEVFKLATSCYDSMA-NYLNFNDLDGIYTYTYEAEKSENCLACSNTPQPLPIEDPNTTTLEDV 365
             ||||.|:|.....|.: :.|.|:.|.|.:.......:..:|.||.        |.|..|.|.|
Human   257 -ALEVLKIAAGLGPSYSGSLLLFDALRGHFRSIRLRSRRLDCAACG--------ERPTVTDLLD- 311

  Fly   366 IKLLCDSP------RFQLKSPALTTVMKDGKRRTLYMSGVKSIEEATRKNLTQSLGELGLHDGQQ 424
            .:..|.|.      ..||.||.....:.|.||  |..||.               ..|.|....|
Human   312 YEAFCGSSATDKCRSLQLLSPEERVSVTDYKR--LLDSGA---------------FHLLLDVRPQ 359

  Fly   425 LTVTDATSPSAMTLQLKY 442
            :.|.....|.|:.:.||:
Human   360 VEVDICRLPHALHIPLKH 377

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Uba3	NP_610913.1	Uba3_RUB	50..346	CDD:238765	67/299 (22%)
		E2_bind	357..442	CDD:462611	23/90 (26%)
MOCS3	NP_055299.1	ThiF_MoeB_HesA_family	62..285	CDD:238386	68/288 (24%)
		Interaction with NFS1. /evidence=ECO:0000269|PubMed:23593335	158..238		15/94 (16%)
		RHOD_ThiF	327..460	CDD:238784	18/68 (26%)