DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Uba3 and uba3

DIOPT Version :9

Sequence 1:	NP_610913.1	Gene:	Uba3 / 36539	FlyBaseID:	FBgn0263697	Length:	450	Species:	Drosophila melanogaster
Sequence 2:	NP_592940.1	Gene:	uba3 / 2542099	PomBaseID:	SPAC24H6.12c	Length:	444	Species:	Schizosaccharomyces pombe

Alignment Length:	449	Identity:	187/449 - (41%)
Similarity:	276/449 - (61%)	Gaps:	38/449 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 SKRFNGLRNILEREGPFCKDGFAASSENLEFLQTKCQVLIIGAGGLGCELLKDLALMGFGNLHVI 78
            |.|.:|....|::.|||..|......|.|:...:. ::|||||||||||:||||||.||.:|.||
pombe    11 SHRHSGWIQSLKKPGPFNLDAPENPEETLKSAFSS-KILIIGAGGLGCEILKDLALSGFRDLSVI 74

  Fly    79 DMDTIELSNLNRQFLFRRTDIGASKAECAARFINARVPTCRVTPHFKKIQDFDESFYQQFHLVVC 143
            |||||:::||||||||..::|...||..||..|..|:|:..|||.:.||||....||::|.|::|
pombe    75 DMDTIDITNLNRQFLFNESNIDEPKANVAASMIMKRIPSTVVTPFYGKIQDKTIEFYKEFKLIIC 139

  Fly   144 GLDSIVARRWINGMLLSMLRYEEDGTIDTSSIVPMIDGGTEGFKGNARVILPGFTACIECTLDLF 208
            ||||:.||||||..|:::.:        |..::|::|||:||.||.||||:|..|:|.||:||:.
pombe   140 GLDSVEARRWINSTLVAIAK--------TGDLIPLVDGGSEGLKGQARVIIPTITSCYECSLDML 196

  Fly   209 PPQVNYPLCTIANTPRLPEHCIEYVKIIQW------------EKQNPFGVPLDG-------DDPQ 254
            .|:::||:||:||||||||||:|:..:::|            .||..| .||||       |:.:
pombe   197 TPKISYPICTLANTPRLPEHCVEWAYLLEWPRVFLNASVDSFSKQEVF-EPLDGKNSNFEPDNIR 260

  Fly   255 HIGWIYERALERSNEFNI--TGVTYRLVQGVVKHIIPAVASTNAAIAAACALEVFKLATSCYDSM 317
            ||.|:.:|::||:|:|.|  :.:....|||:||.||||||||||.|||:|..|..|:.|.....:
pombe   261 HIDWLVKRSIERANKFQIPSSSINRFFVQGIVKRIIPAVASTNAIIAASCCNEALKILTESNPFL 325

  Fly   318 ANYLNFNDLDGIYTYTYEAEKSENCLACSNTPQPLPIEDPNTTTLEDVIKLLCDSPRFQLKSPAL 382
            .||:.:...||.||||:..||..:|..|....:...|...:|.||:|::...  |..:.|::|::
pombe   326 DNYMMYVGEDGAYTYTFNLEKRSDCPVCGVLSEVYDISASSTVTLKDILNHY--SKSYNLQNPSV 388

  Fly   383 TTVMKDGKRRTLYMSGVKSIEEATRKNLTQSLGELGLHDGQQLTVTDATSPSAMTLQLK 441
            :|    .....||::...:::.||.|||:|.:..:...| ..|.:||....:::::||:
pombe   389 ST----AAGTPLYLASPPALQVATSKNLSQPILSITSVD-VNLVITDKNLSTSLSVQLR 442

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Uba3	NP_610913.1	ThiF	48..>220	CDD:279270	91/171 (53%)
		Uba3_RUB	50..346	CDD:238765	153/316 (48%)
		E2_bind	357..442	CDD:285976	22/85 (26%)
uba3	NP_592940.1	ThiF	29..>204	CDD:223552	91/183 (50%)
		Uba3_RUB	46..354	CDD:238765	153/316 (48%)
		E2_bind	365..442	CDD:285976	21/83 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	301	1.000	Domainoid score	I255
eggNOG	1	0.900	-	-		E1_COG0476
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2951
Inparanoid	1	1.050	342	1.000	Inparanoid score	I498
OMA	1	1.010	-	-		QHG54659
OrthoFinder	1	1.000	-	-		FOG0005107
OrthoInspector	1	1.000	-	-		oto102165
orthoMCL	1	0.900	-	-		OOG6_101845
Panther	1	1.100	-	-	LDO	PTHR10953
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1578
SonicParanoid	1	1.000	-	-		X3628
TreeFam	1	0.960	-	-
	14	13.860