DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Uba3 and Uba6

DIOPT Version :9

Sequence 1:	NP_610913.1	Gene:	Uba3 / 36539	FlyBaseID:	FBgn0263697	Length:	450	Species:	Drosophila melanogaster
Sequence 2:	NP_766300.1	Gene:	Uba6 / 231380	MGIID:	1913894	Length:	1053	Species:	Mus musculus

Alignment Length:	488	Identity:	108/488 - (22%)
Similarity:	186/488 - (38%)	Gaps:	125/488 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 LRNILEREGPFCKDGFAASSENLEFL-----------------------QTKCQ------VLIIG 55
            |:.:..:..|.|:..:..:::.:|.|                       .|.||      :.::|
Mouse   403 LKAVTGKFSPLCQWLYLEAADTVESLGNPGHEEFLPRGDRYDAIRACIGNTLCQKLQNLNIFLVG 467

  Fly    56 AGGLGCELLKDLALMGFGN------LHVIDMDTIELSNLNRQFLFRRTDIGASKAECAARFINAR 114
            .|.:|||:||:.||:|.|.      :.|.|.|.||.||||||||||...|...|:..||......
Mouse   468 CGAIGCEMLKNFALLGVGTGREKGMVTVTDPDLIEKSNLNRQFLFRPHHIQKPKSYTAAEATLKI 532

  Fly   115 VPTCRVTPHFKKI-----QDFDESFYQQFHLVVCGLDSIVARRWINGMLLSMLRYEEDGTIDTSS 174
            .|..::..|..|:     ..:.:.||.:..:::..||::.|||:::...|:.||
Mouse   533 NPQLKIDAHLNKVCPATESIYSDEFYTKQDIIITALDNVEARRYVDSRCLANLR----------- 586

  Fly   175 IVPMIDGGTEGFKGNARVILPGFTACIECTLDLFPPQVNYPLCTIANTPRLPEHCIEYVKIIQWE 239
              |::|.||.|.||:..:|:|..|.......|  ||:...|.||:.:.|...||      .|||.
Mouse   587 --PLLDSGTMGTKGHTEIIVPQLTESYNSHRD--PPEEEIPFCTLKSFPAAIEH------TIQWA 641

  Fly   240 KQNPFGVPLDGDDPQHIGWIYERAL-ERSNEFNITGVTYRLVQGVVKHIIPAVASTNAAIAAACA 303
            :..                 :|.:. .:.:.||.....|...:.|::.|      .|......|
Mouse   642 RDK-----------------FESSFSHKPSLFNKFWQAYPSAEDVLQKI------QNGQSLEGC- 682

  Fly   304 LEVFKLA-------TSCYD----SMANYLNFNDLDGIYTYTYEAEKSENCLACSNTPQPLPIEDP 357
            .:|.||.       :.|.:    ....|.|...|..::.:..|....:..|...:..:|
Mouse   683 FQVIKLLSRRPRIWSQCVELARLKFEKYFNHKALQLLHCFPLETRLKDGSLFWQSPKRP------ 741

  Fly   358 NTTTLEDVIKLLCDSP-RFQLKSPALTTVMKDGKR--RTLYMSGVKSIEEATRKNLTQSLGELGL 419
                         .|| :|.|..|...:.::...:  .|:|.... |.::.:..:|...|.|:.:
Mouse   742 -------------PSPIKFDLNEPLHLSFLQSAAKLYATVYCIPF-SEKDLSVNSLMDILSEVKI 792

  Fly   420 HD---GQQLTVTDATS--PSAMTLQLKYQSNEV 447
            .:   ..::..||.|:  |..:.:..:.:.|.|
Mouse   793 EEFKPSNKVVQTDETARKPDHVPVSSEDERNAV 825

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Uba3	NP_610913.1	ThiF	48..>220	CDD:279270	61/188 (32%)
		Uba3_RUB	50..346	CDD:238765	83/324 (26%)
		E2_bind	357..442	CDD:285976	15/92 (16%)
Uba6	NP_766300.1	Ube1	38..1046	CDD:273603	108/488 (22%)
		Ube1_repeat1	43..432	CDD:238768	5/28 (18%)
		E1_4HB	299..362	CDD:292809
		Ube1_repeat2	462..1005	CDD:238767	100/429 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0476
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810