DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Uba3 and rfl-1

DIOPT Version :9

Sequence 1:	NP_610913.1	Gene:	Uba3 / 36539	FlyBaseID:	FBgn0263697	Length:	450	Species:	Drosophila melanogaster
Sequence 2:	NP_498534.2	Gene:	rfl-1 / 175982	WormBaseID:	WBGene00004341	Length:	430	Species:	Caenorhabditis elegans

Alignment Length:	433	Identity:	227/433 - (52%)
Similarity:	298/433 - (68%)	Gaps:	14/433 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 LQSKRFNGLRNILEREGPFCKDGFAASSENLEFLQTKCQVLIIGAGGLGCELLKDLALMGFGNLH 76
            |.::|:..:|.:.:|:..:....|....||.|.|| ..::|:||||||||||||:|||.||..:.
Worm     7 LATERWRSIRRLTDRDSAYKVPWFVPGPENFEALQ-NTKILVIGAGGLGCELLKNLALSGFRTIE 70

  Fly    77 VIDMDTIELSNLNRQFLFRRTDIGASKAECAARFINARVPTCRVTPHFKKIQDFDESFYQQFHLV 141
            |||||||::||||||||||.:|:|.||||.||.|:..||..|:||.|..:|:|..:.||::|.::
Worm    71 VIDMDTIDVSNLNRQFLFRESDVGKSKAEVAAAFVQQRVVGCQVTAHNCRIEDKGQEFYRKFSII 135

  Fly   142 VCGLDSIVARRWINGMLLSMLRYEEDGTIDTSSIVPMIDGGTEGFKGNARVILPGFTACIECTLD 206
            :||||||.|||||||||..::....||..|.::|:|||||||||||||||||.|.|||||:||||
Worm   136 ICGLDSIPARRWINGMLCDLVLEMADGKPDENTIIPMIDGGTEGFKGNARVIYPKFTACIDCTLD 200

  Fly   207 LFPPQVNYPLCTIANTPRLPEHCIEYVKIIQWEKQNPF-GVPLDGDDPQHIGWIYERALERSNEF 270
            |:|||||:||||||:|||||||||||:|::.|.::.|| ||.||.|||.|:.|:.|||..|:.::
Worm   201 LYPPQVNFPLCTIAHTPRLPEHCIEYIKVVVWPEEKPFEGVSLDADDPIHVEWVLERASLRAEKY 265

  Fly   271 NITGVTYRLVQGVVKHIIPAVASTNAAIAAACALEVFKLATSCYDSMANYLNFNDLDGIYTYTYE 335
            ||.||..||..||:|.||||||||||.|||:||||..||||:....:.|||||..:.|.||....
Worm   266 NIRGVDRRLTSGVLKRIIPAVASTNAVIAASCALEALKLATNIAKPIDNYLNFTQIHGAYTSVVS 330

  Fly   336 AEKSENCLACSNTPQPLPIEDPNTTTLEDVIKLLCDSPRFQLKSPALTTVMKDGKRRTLY--MSG 398
            ..|.:|||.||.  ..||.|...::|||.:|..|  |.||.||.|.|.|     ..|.||  .|.
Worm   331 MMKDDNCLTCSG--GRLPFEVSPSSTLESLIIRL--SERFHLKHPTLAT-----STRKLYCISSF 386

  Fly   399 VKSIEEATRKNLTQSLGELGLHDGQQLTVTDATSPSAMTLQLK 441
            :...|:.:::||..|:.:| :.||:::.|:|.....|:||:::
Worm   387 MPQFEQESKENLHTSMKDL-VSDGEEILVSDEALSRALTLRIQ 428

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Uba3	NP_610913.1	ThiF	48..>220	CDD:279270	111/171 (65%)
		Uba3_RUB	50..346	CDD:238765	183/296 (62%)
		E2_bind	357..442	CDD:285976	29/87 (33%)
rfl-1	NP_498534.2	ThiF	33..>214	CDD:279270	116/181 (64%)
		Uba3_RUB	44..341	CDD:238765	183/296 (62%)
		E2_bind	349..429	CDD:285976	29/88 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160167298
Domainoid	1	1.000	383	1.000	Domainoid score	I434
eggNOG	1	0.900	-	-		E1_COG0476
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2951
Inparanoid	1	1.050	435	1.000	Inparanoid score	I950
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54659
OrthoDB	1	1.010	-	-		D256073at33208
OrthoFinder	1	1.000	-	-		FOG0005107
OrthoInspector	1	1.000	-	-		oto18197
orthoMCL	1	0.900	-	-		OOG6_101845
Panther	1	1.100	-	-	LDO	PTHR10953
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1578
SonicParanoid	1	1.000	-	-		X3628
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	15	14.840