Protein Alignment Uba3 and Uba3

DIOPT Version :10

• Sequence 1: NP_610913.1
• Gene: Uba3 / 36539
• FlyBaseID: FBgn0263697
• Length: 450
• Species: Drosophila melanogaster
• Sequence 2: NP_476553.1
• Gene: Uba3 / 117553
• RGDID: 621084
• Length: 462
• Species: Rattus norvegicus
• Alignment Length: 429
• Identity: 274/429 - (63%)
• Similarity: 343/429 - (79%)
• Gaps: 6/429 - (1%)

  Fly    16 RFNGLRNILEREGPFCKDGFAASSENLEFLQTKCQVLIIGAGGLGCELLKDLALMGFGNLHVIDM 80
            |:|.::..|||.|||....|..|:|:|:||...|:||:||||||||||||:|||.||..:|||||
  Rat    37 RWNHVKKFLERSGPFTHPDFEPSTESLQFLLDTCKVLVIGAGGLGCELLKNLALSGFRQIHVIDM 101

  Fly    81 DTIELSNLNRQFLFRRTDIGASKAECAARFINARVPTCRVTPHFKKIQDFDESFYQQFHLVVCGL 145
            |||::||||||||||..|:|..|||.||.|:|.|||.|.|.|||.|||||:::||:|||::||||
  Rat   102 DTIDVSNLNRQFLFRPKDVGRPKAEVAAEFLNDRVPNCNVVPHFNKIQDFNDTFYRQFHIIVCGL 166

  Fly   146 DSIVARRWINGMLLSMLRYEEDGTIDTSSIVPMIDGGTEGFKGNARVILPGFTACIECTLDLFPP 210
            |||:|||||||||:|:|.| |||.:|.|||||:||||||||||||||||||.||||||||:|:||
  Rat   167 DSIIARRWINGMLISLLNY-EDGVLDPSSIVPLIDGGTEGFKGNARVILPGMTACIECTLELYPP 230

  Fly   211 QVNYPLCTIANTPRLPEHCIEYVKIIQWEKQNPF--GVPLDGDDPQHIGWIYERALERSNEFNIT 273
            |||:|:||||:.|||||||||||:::||.|:.||  |||||||||:||.||:::::||::::||.
  Rat   231 QVNFPMCTIASMPRLPEHCIEYVRMLQWPKEQPFGDGVPLDGDDPEHIQWIFQKSVERASQYNIR 295

  Fly   274 GVTYRLVQGVVKHIIPAVASTNAAIAAACALEVFKLATSCYDSMANYLNFNDLDGIYTYTYEAEK 338
            ||||||.|||||.||||||||||.|||.||.||||:|||.|..:.|||.|||:||:||||:|||:
  Rat   296 GVTYRLTQGVVKRIIPAVASTNAVIAAVCATEVFKIATSAYIPLNNYLVFNDVDGLYTYTFEAER 360

  Fly   339 SENCLACSNTPQPLPIEDPNTTTLEDVIKLLCDSPRFQLKSPALTTVMKDGKRRTLYMSGVKSIE 403
            .|||.|||..||  .|:...:..|::|:..|.:|...|:||||:|..: :||.||||:..|.|||
  Rat   361 KENCPACSQLPQ--NIQFSPSAKLQEVLDYLTNSASLQMKSPAITATL-EGKNRTLYLQSVTSIE 422

  Fly   404 EATRKNLTQSLGELGLHDGQQLTVTDATSPSAMTLQLKY 442
            |.||.||:::|.||||.|||:|.|.|.|:|..:..:|.:
  Rat   423 ERTRPNLSKTLKELGLVDGQELAVADVTTPQTVLFKLHF 461

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Uba3	NP_610913.1	Uba3_RUB	50..346	CDD:238765	215/297 (72%)
		E2_bind	357..442	CDD:462611	39/84 (46%)
Uba3	NP_476553.1	Interaction with UBE2M N-terminus. /evidence=ECO:0000250	53..70		6/16 (38%)
		Uba3_RUB	71..368	CDD:238765	216/298 (72%)
		Interaction with UBE2M N-terminus. /evidence=ECO:0000250	157..161		2/3 (67%)
		Interaction with UBE2M N-terminus. /evidence=ECO:0000250	192..217		22/24 (92%)
		Interaction with NEDD8. /evidence=ECO:0000250	227..229		0/1 (0%)
		Interaction with NAE1. /evidence=ECO:0000250	242..248		3/5 (60%)
		Interaction with NAE1. /evidence=ECO:0000250	292..295		2/2 (100%)
		Interaction with UBE2M N-terminus. /evidence=ECO:0000250	331..338		4/6 (67%)
		Interaction with NEDD8. /evidence=ECO:0000250	352..357		3/4 (75%)
		Interaction with UBE2M core domain. /evidence=ECO:0000250	368..462		41/93 (44%)
		E2_bind	376..461	CDD:462611	38/84 (45%)