DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Uba3 and ATG7

DIOPT Version :9

Sequence 1:	NP_610913.1	Gene:	Uba3 / 36539	FlyBaseID:	FBgn0263697	Length:	450	Species:	Drosophila melanogaster
Sequence 2:	XP_006712994.1	Gene:	ATG7 / 10533	HGNCID:	16935	Length:	738	Species:	Homo sapiens

Alignment Length:	378	Identity:	77/378 - (20%)
Similarity:	134/378 - (35%)	Gaps:	112/378 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 LQTKCQVLIIGAGGLGCELLKDLALMGFGNLHV--IDMDTIELSNLNRQFLFRRTDI---GASKA 104
            :..||  |::|||.|||.:.:  .|||:|..|:  :|...|..||..||.|:...|.   |..||
Human   354 VSVKC--LLLGAGTLGCNVAR--TLMGWGVRHITFVDNAKISYSNPVRQPLYEFEDCLGGGKPKA 414

  Fly   105 ECA------------ARFINARVPTCRVTPHFKKI------QDFDESFYQQF---HLVVCGLDSI 148
            ..|            ||..|..:|......:|..:      :|.::  .:|.   |.||..|...
Human   415 LAAADRLQKIFPGVNARGFNMSIPMPGHPVNFSSVTLEQARRDVEQ--LEQLIESHDVVFLLMDT 477

  Fly   149 VARRWINGMLLS-----------------MLRY-----EEDGTIDTSSIVPMIDGGTEGFKGNAR 191
            ...||:..::.:                 ::|:     ::.|..|.....|:......|....|.
Human   478 RESRWLPAVIAASKRKLVINAALGFDTFVVMRHGLKKPKQQGAGDLCPNHPVASADLLGSSLFAN 542

  Fly   192 VILPGF-TACIEC-------------TLDLFPPQVNYPLCTIANTPRLP----EHCIEYVKIIQW 238
            :  ||: ..|..|             |||        ..||::. |.|.    ...:|.:..:..
Human   543 I--PGYKLGCYFCNDVVAPGDSTRDRTLD--------QQCTVSR-PGLAVIAGALAVELMVSVLQ 596

  Fly   239 EKQNPFGVPLDGDDPQHIGWIYERALERSNEFNIT-GVTYRLVQGVVK---HIIPAVASTNAAIA 299
            ..:..:.:....||             |.||...: |:....::|.:.   :::|...:.:.  .
Human   597 HPEGGYAIASSSDD-------------RMNEPPTSLGLVPHQIRGFLSRFDNVLPVSLAFDK--C 646

  Fly   300 AACALEV--------FKLATSCYDSMANYLNFNDLDGIYTYTYEAEKSENCLA 344
            .||:.:|        |......::|..::|  .||.|:.....|.:.:|:.|:
Human   647 TACSSKVLDQYEREGFNFLAKVFNSSHSFL--EDLTGLTLLHQETQAAEDHLS 697

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Uba3	NP_610913.1	ThiF	48..>220	CDD:279270	54/233 (23%)
		Uba3_RUB	50..346	CDD:238765	75/373 (20%)
		E2_bind	357..442	CDD:285976
ATG7	XP_006712994.1	ATG7_N	13..321	CDD:293029
		E1_like_apg7	15..693	CDD:273590	75/372 (20%)
		Apg7	357..682	CDD:238763	73/358 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0476
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900