Protein Alignment Uba3 and UBA2

DIOPT Version :9

• Sequence 1: NP_610913.1
• Gene: Uba3 / 36539
• FlyBaseID: FBgn0263697
• Length: 450
• Species: Drosophila melanogaster
• Sequence 2: XP_005258461.2
• Gene: UBA2 / 10054
• HGNCID: 30661
• Length: 752
• Species: Homo sapiens
• Alignment Length: 537
• Identity: 120/537 - (22%)
• Similarity: 187/537 - (34%)
• Gaps: 200/537 - (37%)

  Fly    78 IDMDTIELSNLNRQFLFRRTDIGASKAECAARFINARVPTCRVTPHFKKIQ--DFDESFYQQFHL 140
            ||:|||::|||||||||::..:|.|||:.|...:....|...:..:...|.  |::..|::||.|
Human   159 IDLDTIDVSNLNRQFLFQKKHVGRSKAQVAKESVLQFYPKANIVAYHDSIMNPDYNVEFFRQFIL 223

  Fly   141 VVCGLDSIVARRWINGMLLSMLRYEEDGTIDTSSIVPMIDGGTEGFKGNARVILPGFTACIECTL 205
            |:..||:..||..:|.|.|             ::.||:|:.||.|:.|....|..|.|.|.||..
Human   224 VMNALDNRAARNHVNRMCL-------------AADVPLIESGTAGYLGQVTTIKKGVTECYECHP 275

  Fly   206 DLFPPQVNYPLCTIANTPRLPEHCIEYVKII---------------------------------- 236
            .  |.|..:|.|||.|||..|.|||.:.|.:
Human   276 K--PTQRTFPGCTIRNTPSEPIHCIVWAKYLFNQLFGEEDADQEVSPDRADPEAAWEPTEAEARA 338

  Fly   237 ---------------------------------------------QWEKQNPFGVPL-------- 248
                                                         .|.|:.| .|||
Human   339 RASNEDGDIKRISTKEWAKSTGYDPVKLFTKLFKDDIRYLLTMDKLWRKRKP-PVPLDWAEVQSQ 402

  Fly   249 ------------------------------------------------------DGDDPQHIGWI 259
                                                                  |.|||..:.::
Human   403 GEETNASDQQNEPQLGLKDQQVLDVKSYARLFSKSIETLRVHLAEKGDGAELIWDKDDPSAMDFV 467

  Fly   260 YERALERSNEFNITGVTYRLVQGVVKHIIPAVASTNAAIAAACALEVFKLATSCYDSMAN-YLNF 323
            ...|..|.:.|::...:...::.:..:||||:|:|||.||....||..|:.:...|.... :||.
Human   468 TSAANLRMHIFSMNMKSRFDIKSMAGNIIPAIATTNAVIAGLIVLEGLKILSGKIDQCRTIFLNK 532

  Fly   324 ND-----------LDGIYTYTYEAEKSENCLACSNTPQ---PLPIEDPNTTTLED-VIKLLCDSP 373
            ..           ||         ..:.||..|::.|:   .|.:......||:| ::|     .
Human   533 QPNPRKKLLVPCALD---------PPNPNCYVCASKPEVTVRLNVHKVTVLTLQDKIVK-----E 583

  Fly   374 RFQLKSPALTTVMKDGKRRTLYMSGVKSIEEATRKNLTQSLGELGLHDGQQLTVTDATSPSAMTL 438
            :|.:.:|.:.  ::|||...|    :.|.|..|..|..:.|.|.|:.:|.:|...|......:.:
Human   584 KFAMVAPDVQ--IEDGKGTIL----ISSEEGETEANNHKKLSEFGIRNGSRLQADDFLQDYTLLI 642

  Fly   439 QLKYQSN-----EVEMV 450
            .:.:..:     |.|:|
Human   643 NILHSEDLGKDVEFEVV 659

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Uba3	NP_610913.1	ThiF	48..>220	CDD:279270	52/143 (36%)
		Uba3_RUB	50..346	CDD:238765	94/422 (22%)
		E2_bind	357..442	CDD:285976	20/85 (24%)
UBA2	XP_005258461.2	Uba2_SUMO	159..556	CDD:238766	94/421 (22%)
		UBA_e1_thiolCys	291..474	CDD:287545	17/183 (9%)
		UAE_UbL	564..650	CDD:291402	21/96 (22%)
		UBA2_C	661..747	CDD:292812

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0476
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D686413at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820