DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tum and ARHGAP25

DIOPT Version :9

Sequence 1:	NP_610912.2	Gene:	tum / 36538	FlyBaseID:	FBgn0086356	Length:	625	Species:	Drosophila melanogaster
Sequence 2:	XP_016860912.1	Gene:	ARHGAP25 / 9938	HGNCID:	28951	Length:	650	Species:	Homo sapiens

Alignment Length:	240	Identity:	62/240 - (25%)
Similarity:	102/240 - (42%)	Gaps:	36/240 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   372 GTPTTKTM-------TGYVTDFAPSIAPMIPALIVHCVNEIEARGLTEVGLYRLSSSEREYKALK 429
            |||.....       ..|...|.|.   ::|.|:..|...|...|..|.|::||...:...|.|:
Human   155 GTPCGAVFGQRLDETVAYEQKFGPH---LVPILVEKCAEFILEHGRNEEGIFRLPGQDNLVKQLR 216

  Fly   430 EQFLRGKATPHLGNTDIYVLCCCVKDFLRSLTEPLIPTSQWKDF--ANAVQNPDTKTAQDMLVKS 492
            :.|..|:......:||::.:...:|.:||.|.||::|.||::.|  ...:.|.|...||..|:|.
Human   217 DAFDAGERPSFDRDTDVHTVASLLKLYLRDLPEPVVPWSQYEGFLLCGQLTNADEAKAQQELMKQ 281

  Fly   493 VKQLPQANRDTLAFLILHFQRI-AQCPVVLMPIDNISLIFGPTIVGYSTPDPDQHAIYTEVFTQ- 555
            :..||:.|...|:::......| ..|.|..|.:||::.:.|..::.....||   |:......|
Human   282 LSILPRDNYSLLSYICRFLHEIQLNCAVNKMSVDNLATVIGVNLIRSKVEDP---AVIMRGTPQI 343

  Fly   556 KQVMKALLE-----LPVSFWEQYIVIDPTRTPATVIKRVPSNKND 595
            ::||..::.     .|.|   :.|.:.|           |:.|||
Human   344 QRVMTMMIRDHEVLFPKS---KDIPLSP-----------PAQKND 374

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tum	NP_610912.2	C1	319..367	CDD:237996
tum	NP_610912.2	RhoGAP_MgcRacGAP	381..570	CDD:239847	53/197 (27%)
ARHGAP25	XP_016860912.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910