DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tum and ARHGAP29

DIOPT Version :9

Sequence 1:	NP_610912.2	Gene:	tum / 36538	FlyBaseID:	FBgn0086356	Length:	625	Species:	Drosophila melanogaster
Sequence 2:	NP_001315593.1	Gene:	ARHGAP29 / 9411	HGNCID:	30207	Length:	1261	Species:	Homo sapiens

Alignment Length:	642	Identity:	140/642 - (21%)
Similarity:	237/642 - (36%)	Gaps:	147/642 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 CMQVLTDGTPEEEFLRFLRMFEQYHEKCAGYAAETARIQNE--LDKSLTKMGDLEGKLFHARRII 77
            |||               |..|....|.:.:.||...:.:.  |.|:|.|  .||.|    ||
Human   332 CMQ---------------RQDEYEKAKSSMFRAEEEHLSSSGGLAKNLNK--QLEKK----RR-- 373

  Fly    78 DMEIKARRQAEHERDAMESKIMAVADLLRHERNLNNETRDKLAFLHT------------------ 124
             :|.:|.::.|   :|.|...:.|.::.....:|.|..|:.||.|.|
Human   374 -LEEEALQKVE---EANELYKVCVTNVEERRNDLENTKREILAQLRTLVFQCDLTLKAVTVNLFH 434

  Fly   125 ---LPSSRKRKSLNAVREDKSYGD--------INSTGSLLSDLSITHSEDDFLDVRTSKSWREHR 178
               |.::....||.::.:.....|        :.:|.|         :|::.:|...:|.....:
Human   435 MQHLQAASLADSLQSLCDSAKLYDPGQEYSEFVKATNS---------TEEEKVDGNVNKHLNSSQ 490

  Fly   179 PS--LPKN------QIPSVGNKRSRLSTGLNGSMSGTTPTTGKSRRSSVGIGVEQHTVDVGQGAE 235
            ||  .|.|      ::|...||..      ....|.:...||.|...|...|:...:...|..:|
Human   491 PSGFGPANSLEDVVRLPDSSNKIE------EDRCSNSADITGPSFIRSWTFGMFSDSESTGGSSE 549

  Fly   236 RFCATTKVTIPQDGQGVIRAESTIESLP--VIAGNERIGDGLSSTPRRSVLKEATAPPLTPVNAM 298
            .....::...|.|..         ..||  ..:|.....|.|..       :|..:|..|..|::
Human   550 SRSLDSESISPGDFH---------RKLPRTPSSGTMSSADDLDE-------REPPSPSETGPNSL 598

  Fly   299 APHVVAESGT---PLQHRPLMRNHTFSQKTFLRG-DNCVQCQKRIRFGAVGLRCRDCPVRCHIDC 359
                    ||   .|..:..: .|.|.:   ||. ..|..|:..:.|  .|:.|.:|.:.||..|
Human   599 --------GTFKKTLMSKAAL-THKFRK---LRSPTKCRDCEGIVVF--QGVECEECLLVCHRKC 649

  Fly   360 RYLLTVSCVPQTGTPTTKTMTGYVTDFAPSIAPMIPALIVHCVNEIEARGLTEVGLYRLSSSERE 424
            ...|.:.|..|.............|..|......||.::..|.:|||.|.|...|:||:..::.:
Human   650 LENLVIICGHQKLPGKIHLFGAEFTQVAKKEPDGIPFILKICASEIENRALCLQGIYRVCGNKIK 714

  Fly   425 YKALKEQFLRGKATPHLGNTDIYVLCCCVKDFLRSLTEPLIPTSQWKDF---ANAVQ--NPDTKT 484
            .:.|.:....|.....:.....:.:|..:|.:||.|.||.|....:|:|   |..:|  |.:.:|
Human   715 TEKLCQALENGMHLVDISEFSSHDICDVLKLYLRQLPEPFILFRLYKEFIDLAKEIQHVNEEQET 779

  Fly   485 AQD----------------MLVKS---VKQLPQANRDTLAFLILHFQRIA-QCPVVLMPIDNISL 529
            .::                :|:||   ::|||.:|.::|.|||:|.:|:. ......|...|:.:
Human   780 KKNSLEDKKWPNMCIEINRILLKSKDLLRQLPASNFNSLHFLIVHLKRVVDHAEENKMNSKNLGV 844

  Fly   530 IFGPTIVGYSTPDPDQHAIYTEVFTQKQVMKALLELPVSFWEQYIVIDPTRTPATVI 586
            ||||:::   .|.|....|......:......|:|..:::.::  :.|.:..|..|:
Human   845 IFGPSLI---RPRPTTAPITISSLAEYSNQARLVEFLITYSQK--IFDGSLQPQDVM 896

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tum	NP_610912.2	C1	319..367	CDD:237996	14/48 (29%)
tum	NP_610912.2	RhoGAP_MgcRacGAP	381..570	CDD:239847	53/213 (25%)
ARHGAP29	NP_001315593.1	BAR	220..436	CDD:299863	30/130 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	481..501		5/19 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	541..600		13/82 (16%)
		C1	612..657	CDD:197519	14/49 (29%)
		RhoGAP_PARG1	669..881	CDD:239874	53/214 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	981..1011
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1117..1153
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1178..1238
		Interaction with PTPN13/PTPL1. /evidence=ECO:0000269\|PubMed:9305890	1258..1261
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910