Protein Alignment tum and ARHGAP18

DIOPT Version :9

• Sequence 1: NP_610912.2
• Gene: tum / 36538
• FlyBaseID: FBgn0086356
• Length: 625
• Species: Drosophila melanogaster
• Sequence 2: NP_277050.2
• Gene: ARHGAP18 / 93663
• HGNCID: 21035
• Length: 663
• Species: Homo sapiens
• Alignment Length: 503
• Identity: 109/503 - (21%)
• Similarity: 195/503 - (38%)
• Gaps: 104/503 - (20%)

  Fly    83 ARRQAEHERDAMESKIMAVADLLRHERNLNNETRDKLAFL-HTLPSSRKRKSLNAVRED------ 140
            :||..::..: .||..:.|.:....:|:::.::.|:|:.. :.:.....:||....:||
Human    38 SRRYGQYTMN-QESTTIKVMEKPPFDRSISQDSLDELSMEDYWIELENIKKSSENSQEDQEVVVV 101

  Fly   141 -----------------------KSYGDINSTGSLLSDLSITHSEDDFLDVRT-SKSWREHRPSL 181
                                   :|.||...:...||.|:.|.:......|.| |::.|:
Human   102 KEPDEGELEEEWLKEAGLSNLFGESAGDPQESIVFLSTLTRTQAAAVQKRVETVSQTLRK----- 161

  Fly   182 PKN---QIPSV----GNKRSRLSTGLNGSMSGTTPTT-----GKSRRSSVGIGVEQHTVDVGQGA 234
             ||   |||.|    ..:|....|...|:.|.:..|.     |:...:|..:|.|:........|
Human   162 -KNKQYQIPDVRDIFAQQRESKETAPGGTESQSLRTNENKYQGRDDEASNLVGEEKLIPPEETPA 225

  Fly   235 ERFCATTKVTIPQDGQGVIRAESTIESLPVIAGNERIGDGLSSTPRRSVLKEATAPPLTPVNAMA 299
            .......:|:..:  |.:.:.||:.|.:....|::      ::.|...:.|:.|.  .|.:..:|
Human   226 PETDINLEVSFAE--QALNQKESSKEKIQKSKGDD------ATLPSFRLPKDKTG--TTRIGDLA 280

  Fly   300 PHVVAESGTPLQHRPLMRNHTFSQKTFLRGDNCVQCQKRIRFGAVGLRCRDCPVRCHIDCRYLLT 364
            |..:.:    :.|..|:      :.|.|.....::.:::   .||.::.:|.            .
Human   281 PQDMKK----VCHLALI------ELTALYDVLGIELKQQ---KAVKIKTKDS------------G 320

  Fly   365 VSCVPQTGTPTTKTMTGYVTDFAPSIAPM-IPALIVHCVNEIEARGLTEVGLYRLSSSEREYK-- 426
            :.|||         :|..:......:..| ||.:....::.||.|||...||.|:..:....|
Human   321 LFCVP---------LTALLEQDQRKVPGMRIPLIFQKLISRIEERGLETEGLLRIPGAAIRIKNL 376

  Fly   427 --ALKEQFLRGKATPHLGNTDIYVLCCCVKDFLRSLTEPLIPTSQWKDFANAVQNPDTKTAQ-DM 488
              .|:.:|..|  |.:..:...:.....:|.|:|.|.:||:.....|.| .||||..||..| ..
Human   377 CQELEAKFYEG--TFNWESVKQHDAASLLKLFIRELPQPLLSVEYLKAF-QAVQNLPTKKQQLQA 438

  Fly   489 LVKSVKQLPQANRDTLAFLILHFQRIAQCPVV-LMPIDNISLIFGPTI 535
            |...|..||.||||||..|:...||:...... .|.:.|::::..|.:
Human   439 LNLLVILLPDANRDTLKALLEFLQRVIDNKEKNKMTVMNVAMVMAPNL 486

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tum	NP_610912.2	C1	319..367	CDD:237996	5/47 (11%)
		RhoGAP_MgcRacGAP	381..570	CDD:239847	47/162 (29%)
ARHGAP18	NP_277050.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	15..37
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	179..227		10/47 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	243..277		8/41 (20%)
		RhoGAP_ARHGAP18	321..534	CDD:239856	51/178 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910