DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tum and BEM3

DIOPT Version :9

Sequence 1:	NP_610912.2	Gene:	tum / 36538	FlyBaseID:	FBgn0086356	Length:	625	Species:	Drosophila melanogaster
Sequence 2:	NP_015210.1	Gene:	BEM3 / 855988	SGDID:	S000006036	Length:	1128	Species:	Saccharomyces cerevisiae

Alignment Length:	760	Identity:	136/760 - (17%)
Similarity:	246/760 - (32%)	Gaps:	240/760 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LSALASFDDLR----RCMQVLTDGTPEEEFLRFLRMFEQYHEKCAG---------YAAETARIQN 54
            |..||.::|.|    :.::.:..||                  |:|         ...|..:::.
Yeast    15 LELLAQYNDHRSKKDKSIEHIEKGT------------------CSGKERNPSYDEIFTENIKLKL 61

  Fly    55 ELDKSLTKMGDLEGKLFHARRIIDMEIKARRQAEHE-------RDAMESKI--------MAVADL 104
            ::.:..|::..||       ::||| ::..|:|..|       .|:.:|.:        ...|:.
Yeast    62 QVQEYETEIESLE-------KVIDM-LQKNREASLEVVLEQVQNDSRDSYVNDQSFVLPPRSAER 118

  Fly   105 LRHERNLN-------------NETRDKLAFLHTLP-------SSRKRKSL-NAVREDKSYGDINS 148
            ..|.::||             ::...:.:...|:|       :|..||.| |.:..|:...:.:.
Yeast   119 KAHIKSLNLPIPTLSPPLQQGSDVALETSVTPTVPQIGVTSNTSISRKHLQNMILNDEIEANSSF 183

  Fly   149 TGSLLSDLSIT-----HSED------------DFLDVRT----SKSWREHRPSLPKNQIPSVGNK 192
            :...:.:.|::     |||.            ..:.:::    |||..:.|...|:|........
Yeast   184 SSPKIINRSVSSPTKIHSEQLASPAASVTYTTSRITIKSPNKGSKSPLQERLRSPQNPNRMTAVI 248

  Fly   193 RSRLSTGLNGSMSGTTPTTGKSRRSSVGIGVEQHTVDVGQGAERFCATTKVTIPQDGQGVIRAES 257
            .:.|.:.|..|.|.......:|:.       :|.|.|..|..:|..::...:....|.....|:|
Yeast   249 NNHLHSPLKASTSNNLDELTESKS-------QQLTNDAIQKNDRVYSSITSSAYTTGTPTSAAKS 306

  Fly   258 TIESLPVIAG-NERIGDGLSSTPR----------------------------RSVLKEATAPPLT 293
            ....|.|..| |:.:|...:|..:                            :|.:.|:..||..
Yeast   307 PSSLLEVKEGENKALGFSPASKEKLDDFTQLLDSSFGEEDLVNTDSKDPLSIKSTINESLPPPPA 371

  Fly   294 PVNAMAPHVVAESGTPLQHRPLMRNHTFSQKTFLRGDNCVQCQKRIRFGAVGLRCRDCPVRCHID 358
            |....:|   ..||......|| .:|..|.....:.|:        .|||...:....||
Yeast   372 PPTFFSP---TSSGNIKNSTPL-SSHLASPVILNKKDD--------NFGAQSAKNLKKPV----- 419

  Fly   359 CRYLLTVSCVPQTGTPTTKTMTGYVTDFAPSIAPMIPALIVHCVNEIEARGLTEVGLYRLSSSER 423
                || |.:|...|..:.|...      .|:.|..|.     .:..:.:.|.|......:::..
Yeast   420 ----LT-SSLPNLSTKLSTTSQN------ASLPPNPPV-----ESSSKQKQLGETASIHSTNTLN 468

  Fly   424 EYKALKEQFLRGKATPHLGNTDIYVLCCCVKDFLRSLTEPLIPTSQWKDFANAVQNPDTKTAQDM 488
            .:.:..:..|:....||..:..      .||...:||.         .|....||..|..|.|
Yeast   469 TFSSTPQGSLKTLRRPHASSVS------TVKSVAQSLK---------SDIPLFVQPEDFGTIQ-- 516

  Fly   489 LVKSVKQLPQANRDTLAFLILHFQR--------------------------IAQCPVVLMPIDNI 527
             ::.:..|.:.|.|.|:.||....|                          :...|:..:|...:
Yeast   517 -IEVLSTLYRDNEDDLSILIAIIDRKSGKEMFKFSKSIHKVRELDVYMKSHVPDLPLPTLPDRQL 580

  Fly   528 SLIFGPTIVGYSTPDPDQHAIYTEVFTQKQVMKAL-LELPVSFWEQYIVIDPTRTP--------- 582
            .....||.|.......:|:  ||.:|:..:..|.: |::     .|:|..|...||
Yeast   581 FQTLSPTKVDTRKNILNQY--YTSIFSVPEFPKNVGLKI-----AQFISTDTVMTPPMMDDNVKD 638

  Fly   583 ATVIKRVPSN--------------KNDLLSLYATPFKGGTIKKRK 613
            .:::.|.|..              ::|:|.|:.......|||.|:
Yeast   639 GSLLLRRPKTLTGNSTWRVRYGILRDDVLQLFDKNQLTETIKLRQ 683

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tum	NP_610912.2	C1	319..367	CDD:237996	10/47 (21%)
tum	NP_610912.2	RhoGAP_MgcRacGAP	381..570	CDD:239847	36/215 (17%)
BEM3	NP_015210.1	PX	520..622	CDD:214610	19/108 (18%)
		PH_Bem3	633..741	CDD:270096	9/51 (18%)
		RhoGAP	904..1110	CDD:413382
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910