DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tum and ARHGAP19

DIOPT Version :9

Sequence 1:	NP_610912.2	Gene:	tum / 36538	FlyBaseID:	FBgn0086356	Length:	625	Species:	Drosophila melanogaster
Sequence 2:	NP_116289.4	Gene:	ARHGAP19 / 84986	HGNCID:	23724	Length:	494	Species:	Homo sapiens

Alignment Length:	332	Identity:	70/332 - (21%)
Similarity:	99/332 - (29%)	Gaps:	137/332 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly   408 RGLTEVGLYRLSSSEREYKALKEQFLRGKATPHLGN-TDIYV---------LCCCVKDFLRSLTE 462
            :.|...||:|:..:     ::::|.||..    |.| |||.:         :...:|.||..|.|
Human   134 KNLRVEGLFRVPGN-----SVRQQILRDA----LNNGTDIDLESGEFHSNDVATLLKMFLGELPE 189

  Fly   463 PLI------------PTSQWKDFANAVQNPDTKTAQDMLVKSVKQLPQANRDTL----------- 504
            ||:            ...|:.|..|....||.....:.|......||..||:.|
Human   190 PLLTHKHFNAHLKIADLMQFDDKGNKTNIPDKDRQIEALQLLFLILPPPNRNLLKLLLDLLYQTA 254

  Fly   505 -------------------------------------------AFLILHFQRIAQCPVVLMPIDN 526
                                                       ||:|.|.|::.:.|..:.....
Human   255 KKQDKNKMSAYNLALMFAPHVLWPKNVTANDLQENITKLNSGMAFMIKHSQKLFKAPAYIRECAR 319

  Fly   527 ISLIFGPTIVGYSTPDPDQHA-IYTEVF-------------------TQKQVMKALLEL------ 565
            :..:...|..  |..|.|..| .:|:.|                   ||....:||.||
Human   320 LHYLGSRTQA--SKDDLDLIASCHTKSFQLAKSQKRNRVDSCPHQEETQHHTEEALRELFQHVHD 382

  Fly   566 -PVS---------FWEQYIVIDPTRTPAT--VIKRVPSNKNDLLSLYATPFKGGTIKKRKFYGTP 618
             |.|         |.:|.:...|.|.|:|  |.||..|..          |.|  :.|||..|..
Human   383 MPESAKKKQLIRQFNKQSLTQTPGREPSTSQVQKRARSRS----------FSG--LIKRKVLGNQ 435

  Fly   619 PASAHKK 625
            ..|..||
Human   436 MMSEKKK 442

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tum	NP_610912.2	C1	319..367	CDD:237996
tum	NP_610912.2	RhoGAP_MgcRacGAP	381..570	CDD:239847	51/273 (19%)
ARHGAP19	NP_116289.4	RhoGAP_ARHGAP19	113..320	CDD:239857	36/194 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	349..368		2/18 (11%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	399..421		8/21 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910