DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tum and Chn2

DIOPT Version :9

Sequence 1:	NP_610912.2	Gene:	tum / 36538	FlyBaseID:	FBgn0086356	Length:	625	Species:	Drosophila melanogaster
Sequence 2:	NP_114473.2	Gene:	Chn2 / 84031	RGDID:	620140	Length:	468	Species:	Rattus norvegicus

Alignment Length:	312	Identity:	81/312 - (25%)
Similarity:	136/312 - (43%)	Gaps:	29/312 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   269 ERIGDGLSSTPRRSVLKEATAPPLTPVNAMAPHVVAESGTPL-QHRPLMRNHTFSQKTFLRGDN- 331
            |::...||.:...|.....|....|||..::..|...:.|.. .|....:.|.|...|| ||.:
  Rat   164 EKVSRRLSRSKNESRKAGVTHEEHTPVEKISSLVRRAALTHNDNHFNYEKTHNFKVHTF-RGPHW 227

  Fly   332 CVQCQKRIRFG--AVGLRCRDCPVRCHIDCRYLLTVSCVPQTGTPTTKTMTGYVTDFAPSI---- 390
            |..| ....:|  |.|:||.||.:..|..|...:...|.|.    ..:....|..|....:
  Rat   228 CEYC-ANFMWGLIAQGVRCSDCGLNVHKQCSKHVPNDCQPD----LKRIKKVYCCDLTTLVKAHN 287

  Fly   391 --APMIPALIVHCVNEIEARGLTEVGLYRLSSSEREYKALKEQFLR-GKATPHLGN--TDIYVLC 450
              .||:..:   |:.|||||||...||||:|......:.:|..|.| |:......|  .||.::.
  Rat   288 TQRPMVVDI---CIREIEARGLKSEGLYRVSGFTEHIEDVKMAFDRDGEKADISANIYPDINIIT 349

  Fly   451 CCVKDFLRSLTEPLIPTSQWKDFANAVQNPDTKTAQDMLVKSVKQLPQANRDTLAFLILHFQRIA 515
            ..:|.:.|.|..|:|....:..|..|.:..:.....:.:.:.:..||.|:.:||.:|::|.:::.
  Rat   350 GALKLYFRDLPIPIITYDTYSKFIEAAKISNADERLEAVHEVLMLLPPAHYETLRYLMIHLKKVT 414

  Fly   516 QCPV-VLMPIDNISLIFGPTIVGYSTPDPDQHAIYT--EVFTQKQVMKALLE 564
            .... .||..:|:.::||||::    ..|:...:.|  ::..||.:::.|:|
  Rat   415 MNEKDNLMNAENLGIVFGPTLM----RPPEDSTLTTLHDMRYQKLIVQILIE 462

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tum	NP_610912.2	C1	319..367	CDD:237996	17/50 (34%)
tum	NP_610912.2	RhoGAP_MgcRacGAP	381..570	CDD:239847	51/196 (26%)
Chn2	NP_114473.2	SH2_a2chimerin_b2chimerin	52..138	CDD:198215
		C1_betaCHN	210..270	CDD:410407	19/65 (29%)
		RhoGAP_chimaerin	275..468	CDD:239837	51/195 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910