DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tum and ARHGAP10

DIOPT Version :9

Sequence 1:	NP_610912.2	Gene:	tum / 36538	FlyBaseID:	FBgn0086356	Length:	625	Species:	Drosophila melanogaster
Sequence 2:	NP_078881.3	Gene:	ARHGAP10 / 79658	HGNCID:	26099	Length:	786	Species:	Homo sapiens

Alignment Length:	650	Identity:	122/650 - (18%)
Similarity:	217/650 - (33%)	Gaps:	222/650 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 YHEKCAGYAAETARIQNELDKSLTKMGDLEGK-LFHARRIIDMEIKARRQAEHERDAMESKIM-- 99
            :.|:...:.||..| .|:..|.|.|    :|| |..|.:.:.:   |:|:..|.....:.:.:
Human    18 FRERIRAHEAELER-TNKFIKELIK----DGKNLIAATKSLSV---AQRKFAHSLRDFKFEFIGD 74

  Fly   100 AVADLLRHERNLNNETRDKLAFLHTLPSSR------------------KRKSLNAVREDKSYGD- 145
            ||.|   .||.::...|:...||..|...|                  :::.|.||:|:|...|
Human    75 AVTD---DERCIDASLREFSNFLKNLEEQREIMALSVTETLIKPLEKFRKEQLGAVKEEKKKFDK 136

  Fly   146 -INSTGSLL-----------------SDLSITHSEDDFLDV------------------------ 168
             .....||:                 :|:.:..:...|.::
Human   137 ETEKNYSLIDKHLNLSAKKKDSHLQEADIQVEQNRQHFYELSLEYVCKLQEIQERKKFEFVEPML 201

  Fly   169 --------------RTSKSWREHRPSLPKNQIPSVGNKRSRLSTGLNGSMSGTTPTTGKSRRSSV 219
                          ..:|.:..::..|..|    :.|.|:|    ..|:.|.......|.|::.
Human   202 SFFQGMFTFYHQGHELAKDFNHYKMELQIN----IQNTRNR----FEGTRSEVEELMNKIRQNP- 257

  Fly   220 GIGVEQHTVDVGQGAERFCATTKVTIPQDGQGVIRAESTIESLPVIAGNERIGDGLSSTPRRSVL 284
                :.|     :.|.:|.|          :|.:..:   |..|...|        ||..:...:
Human   258 ----KDH-----KRASQFTA----------EGYLYVQ---EKRPAPFG--------SSWVKHYCM 292

  Fly   285 KEATAPPLTPVNAMAPHVVAESGTPLQHR---PLMRNHTFSQKTFLRGDNCVQCQKRIRFGAVGL 346
            ....|.....:             |.:||   .|.....|    ||:     :|.||
Human   293 YRKAAKKFNMI-------------PFEHRSGGKLGDGEVF----FLK-----ECTKR-------- 327

  Fly   347 RCRDCPVRCH---IDCRYLLTVSCVPQTGTPTTKTMTGYVTD------------------FAPSI 390
                     |   ||.|:...:....:.|  .:.||..:..:                  |..:|
Human   328 ---------HTDSIDRRFCFDIEAADRPG--VSLTMQAFSEEERKQWLEALGGKEALSHSFNTAI 381

  Fly   391 AP----------MIPALIVHCVNEIEARGLTEVGLY----------RLSSSEREYKALKEQFLRG 435
            .|          |...:|..|::.:|.||:.:.|||          ||.|...:.|...|..|..
Human   382 IPRPEGNAQLDKMGFTIIRKCISAVETRGINDQGLYRVVGVSSKVQRLLSMLMDVKTCNEVDLEN 446

  Fly   436 KATPHLGNTDIYVLCCCVKDFLRSLTEPLIPTSQWKDFANAVQNPDTKTAQDMLVKSVKQLPQAN 500
            .|     :.::..:...:|.:||||.|||:......||....::...::..:.:...|.:||:.|
Human   447 SA-----DWEVKTITSALKQYLRSLPEPLMTYELHGDFIVPAKSGSPESRVNAIHFLVHKLPEKN 506

  Fly   501 RDTLAFLILHFQRIA-QCPVVLMPIDNISLIFGPTIVGYSTPDPDQHAIYTEVFTQKQVMKALLE 564
            ::.|..|:.|...:: .....||.:.|:.::||||::   .|..:..|...::..|..|::.|:|
Human   507 KEMLDILVKHLTNVSNHSKQNLMTVANLGVVFGPTLM---RPQEETVAALMDLKFQNIVVEILIE 568

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tum	NP_610912.2	C1	319..367	CDD:237996	10/50 (20%)
tum	NP_610912.2	RhoGAP_MgcRacGAP	381..570	CDD:239847	48/222 (22%)
ARHGAP10	NP_078881.3	BAR_GRAF2	19..225	CDD:153319	36/216 (17%)
		BAR-PH_GRAF_family	267..374	CDD:269953	25/168 (15%)
		RhoGAP_Graf	367..569	CDD:239839	48/209 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	576..608
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	621..727
		SH3_GRAF2	732..785	CDD:212998
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910