Protein Alignment tum and ophn1

DIOPT Version :9

• Sequence 1: NP_610912.2
• Gene: tum / 36538
• FlyBaseID: FBgn0086356
• Length: 625
• Species: Drosophila melanogaster
• Sequence 2: NP_001072480.1
• Gene: ophn1 / 779935
• XenbaseID: XB-GENE-1009725
• Length: 792
• Species: Xenopus tropicalis
• Alignment Length: 639
• Identity: 122/639 - (19%)
• Similarity: 201/639 - (31%)
• Gaps: 225/639 - (35%)

  Fly    22 GTPEEEFLRFLRMFEQYH---EKCAGYAAETARIQ-NELDKSL--TKMGDLEGKLFHARRIIDME 80
            |..:|...:|.:..|:|:   ::....:::...:| ||.|:.:  .|....|..|.:..:|.:::
 Frog   125 GLTKERKKKFDKDGEKYYSLLDRHVNLSSKKKEVQLNEADQQVDREKQNFYESSLEYVYQIQEVQ 189

  Fly    81 IKARRQAEHERDAMESKIMAVADLLRHERNLNNE-TRDKLAFLHTLPSS--RKRKSLNAVRED-- 140
                   |.::..:...::.....|....||..| |:|.|.:...|..|  ..|...::.||:
 Frog   190 -------ESKKFCIVEPVLTFLHCLFTSNNLTFELTQDFLPYKQQLQLSLQNTRNHFSSTREELE 247

  Fly   141 -------------KSYGDINSTGSLLSD----LSITHSEDDFLDVRTSKSWREH----------R 178
                         |..|.....|.|.|.    |.||              |.:|          .
 Frog   248 DLKKRMTEAPMMCKLRGQSTIEGYLYSQEKRALGIT--------------WVKHYCKYEKEGKVL 298

  Fly   179 PSLPKNQIPSVGNKRSRLSTGLNGSMSGTTPTTGKS--RRSSVGIGVEQHTVDVGQGAERFCATT 241
            ..:|..|.|              ||..|....|.||  ||.|..|.            :|||...
 Frog   299 SMMPLEQKP--------------GSRQGNQELTLKSCIRRKSDSID------------KRFCFDV 337

  Fly   242 KVTIPQDGQGVIRAESTIESLPVIAGNERIG----DGLSSTPRRSVLKEATAPPLTPVNAMAPHV 302
            :.                        |||.|    ..||.|.||           ..:.||
 Frog   338 ET------------------------NERPGTLTLQALSETNRR-----------LWIEAM---- 363

  Fly   303 VAESGTPLQHRPLMRNHTFSQKTFLRGDNCVQCQKRIRFGAVGLRCRDCPVRCHIDCRYLLTVSC 367
              :...|:.|.|:.:                  :..:....||.|
 Frog   364 --DGKEPIYHSPITK------------------RDEMELNEVGFR-------------------- 388

  Fly   368 VPQTGTPTTKTMTGYVTDFAPSIAPMIPALIVHCVNEIEARGLTEVGLYRLSSSEREYKALKEQF 432
                                         .:..|:|.:||.|:|..|:||...|..:.:.|...|
 Frog   389 -----------------------------FVRKCINAVEATGITSEGVYRTVGSNIQVQKLLNAF 424

  Fly   433 LRGKATPHLGNT-------DIYVLCCCVKDFLRSLTEPLIPTSQWKDFANAVQNPDTKTAQDMLV 490
            ...|..   ||.       ||..:...:|.:||:|:||::.....:|...|.::.:.......:.
 Frog   425 FDPKCP---GNVDLQNSEWDIKTITSSLKFYLRNLSEPVMTYKLHRDLVLASKSENLDYRLGAIH 486

  Fly   491 KSVKQLPQANRDTLAFLILHFQRIAQ-CPVVLMPIDNISLIFGPTIVGYSTPDPDQHAIYTEVFT 554
            ..|.:||:.:|:.|..:|.|..|:.: ....||...|:.:|||||::   ....|..|....:..
 Frog   487 CLVYRLPENHREMLELIIRHLSRVCEFSRENLMSPSNMGVIFGPTLM---RAQEDTVAAMMNIKF 548

  Fly   555 QKQVMKALLELPVSFWEQYI------------VIDPTRTPATVIKRVPSNKNDL 596
            |..|::.|:|.....:...:            :...|..|.|:.||....::.|
 Frog   549 QNIVVELLIENCKKIFSGPLDDNCGPPVPPPRITPRTHIPITISKRQARGRSGL 602

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tum	NP_610912.2	C1	319..367	CDD:237996	3/47 (6%)
		RhoGAP_MgcRacGAP	381..570	CDD:239847	47/196 (24%)
ophn1	NP_001072480.1	BAR_OPHN1	19..225	CDD:153317	21/106 (20%)
		BAR-PH_GRAF_family	267..370	CDD:269953	36/183 (20%)
		RhoGAP	363..559	CDD:383032	53/274 (19%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910