Protein Alignment tum and Arhgap12

DIOPT Version :9

• Sequence 1: NP_610912.2
• Gene: tum / 36538
• FlyBaseID: FBgn0086356
• Length: 625
• Species: Drosophila melanogaster
• Sequence 2: XP_006526377.1
• Gene: Arhgap12 / 75415
• MGIID: 1922665
• Length: 843
• Species: Mus musculus
• Alignment Length: 637
• Identity: 136/637 - (21%)
• Similarity: 231/637 - (36%)
• Gaps: 217/637 - (34%)

  Fly    36 EQYHEKC------------AGYAAE------TARIQNELDKSLTKMGDLEGKLFH-----ARRII 77
            |.||..|            .|::.|      |....:...:...|..|.:|:.::     :|.
Mouse   319 ENYHSSCFSQSDSQCGSPPRGWSEELDERGHTLYTSDYTKEKWLKHVDDQGRQYYYSADGSRS-- 381

  Fly    78 DMEI-KARRQAEHERDAMESKIM-------AVADLLRH------ERNLNNETRDKLAFLHTLP-- 126
            :.|: |....::.:|:.::|:.:       .|....||      ..:.::.|..||.    ||
Mouse   382 EWELPKYNASSQQQREIIKSRSLDRRLQEPIVLTKWRHSTIVLDSNDKDSPTTTKLC----LPEN 442

  Fly   127 -----SSRKRKSLNAVREDKSYGDINSTGSLLSDLSITHSEDDFLDVRTSKSWREHRPSLPKNQI 186
                 ||:.:....:::..:.||.:|.|       .||.:     ..:..|:|
Mouse   443 ESPPTSSKHQDPAGSLKGQEKYGLLNVT-------KITEN-----GKKVRKNW------------ 483

  Fly   187 PSVGNKRSRLSTG--LNGSMSGTTPTTGKSRRSSVGIGVEQ----HTVDVGQGAERFCAT----- 240
                     ||:.  |.||....|.|.|.   |:...|..|    .|||: :||....|:
Mouse   484 ---------LSSWAVLQGSSLLFTKTQGS---STSWFGSNQSKPEFTVDL-KGAVIEMASKDKSS 535

  Fly   241 ------------TKVTIPQDGQGVIRAESTIESLPVIAGNERIGDGLSSTPRRSVLKEATAPPLT 293
                        |::.|..|...||.....:               ||||....|.:...|
Mouse   536 KKNVFELKTRQGTELLIQSDNDAVINDWFKV---------------LSSTINNQVAEADEA---- 581

  Fly   294 PVNAMAPHVVAESGTPLQHRPLMRNH--TFSQKTF-----LRG---DNCVQ--CQKRIRFGAVGL 346
                      ||..||  ..|.:..|  ...||..     ::|   |:..|  .:|.::
Mouse   582 ----------AEEETP--DSPGVEKHDKEKDQKELKKLRSMKGSSMDSSEQKKTKKNLK------ 628

  Fly   347 RCRDCPVRCHIDCRYLLTVSCVPQTGTPTTKTM--TGYVTD--FAPSIAPM-------IPALIVH 400
                         ::|        |..||.:.:  .||:.|  |..::|.:       :|..:..
Mouse   629 -------------KFL--------TRRPTLQAVREKGYIKDQVFGSNLANLCQRENGTVPKFVKL 672

  Fly   401 CVNEIEARGLTEVGLYRLSSSEREYKALKEQFLRGKATPH-----LGNT---DIYVLCCCVKDFL 457
            |:..:|..||...|:||:|.:....:.|:      .|..|     |.::   ||:|:...:|.|.
Mouse   673 CIEHVEEHGLDVDGIYRVSGNLAVIQKLR------FAVNHDEKLDLNDSKWEDIHVITGALKMFF 731

  Fly   458 RSLTEPLIPTSQWKDFANAV-QNPDTK--TAQDMLVKSVKQLPQANRDTLAFLILHFQRIAQ-CP 518
            |.|.|||...:.:.||.||: |.|..:  ..:|:    ::|||:.|:||:..|..|.:|:.: ..
Mouse   732 RELPEPLFTFNHFNDFVNAIKQEPRQRVTAVKDL----IRQLPKPNQDTMQILFRHLKRVIENGE 792

  Fly   519 VVLMPIDNISLIFGPTIVGYSTPDPDQHAIYTEVFTQKQVMK-ALLELPVSF 569
            ...|...:|:::||||::   .|:.:...|......|.|::: .||||...|
Mouse   793 KNRMTYQSIAIVFGPTLL---KPERETGNIAVHTVYQNQIVELILLELSTVF 841

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tum	NP_610912.2	C1	319..367	CDD:237996	8/59 (14%)
		RhoGAP_MgcRacGAP	381..570	CDD:239847	59/211 (28%)
Arhgap12	XP_006526377.1	SH3_ARHGAP12	13..72	CDD:213003
		SH3-WW_linker	69..264	CDD:374675
		PRP40	257..>409	CDD:227435	15/91 (16%)
		WW	266..296	CDD:238122
		PH_ARHGAP9-like	462..573	CDD:270053	34/162 (21%)
		RhoGAP_ARHGAP27_15_12_9	651..836	CDD:239868	52/197 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910