Protein Alignment tum and Arhgap21

DIOPT Version :9

• Sequence 1: NP_610912.2
• Gene: tum / 36538
• FlyBaseID: FBgn0086356
• Length: 625
• Species: Drosophila melanogaster
• Sequence 2: XP_006497601.1
• Gene: Arhgap21 / 71435
• MGIID: 1918685
• Length: 1957
• Species: Mus musculus
• Alignment Length: 617
• Identity: 129/617 - (20%)
• Similarity: 223/617 - (36%)
• Gaps: 167/617 - (27%)

  Fly    84 RRQAEHERDAMESKIMAVADLLRHERN------LNNETRD-KLAFLHTLPSSRKRKSLNAVREDK 141
            |||..|:::::....:......:.||:      |::...| ||:|.|.       .||..::...
Mouse   858 RRQLSHDQESVGPPSLDGQHSSKTERSKSYDEGLDDYREDAKLSFKHV-------SSLKGIKITD 915

  Fly   142 SYGDINSTGSLLSDLSITHSEDDFLDVRTSKSWREHRPSLPKNQIPSVGNKRSRLSTGLNGS--- 203
            |......:||....     |.:.|.|. ..:.|.:.|        |.|.:|..|    :.||
Mouse   916 SQKSSEDSGSRKGS-----SSEVFSDA-AREGWLQFR--------PLVTDKGKR----VGGSIRP 962

  Fly   204 -------MSGTTPTTGKSRRSSVGIGVEQHTVDVG----------------------------QG 233
                   :.|.:....|.||.......|:..:.|.                            |.
Mouse   963 WKQMYVVLRGHSLYLYKDRREQTTPSEEEQPISVNACLIDISYSETKRRNVFRLTTSDCECLFQA 1027

  Fly   234 AERFCATTKVTIPQDGQGVIRAESTIESLPVIAGNERI----------GDGLSSTPRRSV----- 283
            .:|....:.:...|:...:...::.:.:..:|  :.||          .:.|..|||:|:
Mouse  1028 EDRDDMLSWIKTIQESSNLNEEDTGVTNRDLI--SRRIKEYNSLLSSKTEQLPKTPRQSLSIRQT 1090

  Fly   284 LKEATAPPLTPVNAMAPHVVAESGTPLQHRPLMRNHTFSQK---TFLRGDNCVQC----QKRIRF 341
            |..|.:.|.|    .:||...|..   :.:.|.::.|...|   |:.||...:..    :|....
Mouse  1091 LLGAKSEPKT----QSPHSPKEES---ERKLLSKDDTSPPKDKGTWRRGIPSIVRKTFEKKPAAT 1148

  Fly   342 GAVGLRCRDCPVRCHIDCRYLLTVSCVPQTGTPTTKTMTGYVTDFAPSIAPMIPALIVHCVNEIE 406
            |..|:|..||| ..|.: ||                                ||.::..|...:|
Mouse  1149 GTFGVRLDDCP-PAHTN-RY--------------------------------IPLIVDICCKLVE 1179

  Fly   407 ARGLTEVGLYRLSSSEREYKALKEQFLRGKATPHLGN---TDIYVLCCCVKDFLRSLTEPLIPTS 468
            .|||...|:||:..:.....:::|:..:|.|...:.:   .|:.|:...:|.|.|.|.|||....
Mouse  1180 ERGLEYTGIYRVPGNNAAISSMQEELNKGMADIDIQDDKWRDLNVISSLLKSFFRKLPEPLFTND 1244

  Fly   469 QWKDFANAVQNPDTKTAQDMLVKSVKQLPQANRDTLAFLILHFQRIAQ-CPVVLMPIDNISLIFG 532
            ::.||..|.:..|.......|.:.:..||:.:.:||.||..|.:.:|: .....|...|::::||
Mouse  1245 KYADFIEANRKEDPLDRLRTLKRLIHDLPEHHFETLKFLSAHLKTVAENSEKNKMEPRNLAIVFG 1309

  Fly   533 PTIVGYS--------TPDPDQHAIYTEV-------FTQKQVMKALLELPVSFWEQYIVIDPTRTP 582
            ||:|..|        |..|||:.|...:       ||::..     |.|::..::...:|....|
Mouse  1310 PTLVRTSEDNMTHMVTHMPDQYKIVETLIQHHDWFFTEEGA-----EEPLTAVQEENTVDSQPVP 1369

  Fly   583 -----ATVIKR---VPSNKNDLLSLYATPFKG 606
                 .|.|.|   :|.:.:|..:..:...||
Mouse  1370 NIDHLLTNIGRTGVLPGDVSDSATSDSAKSKG 1401

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tum	NP_610912.2	C1	319..367	CDD:237996	15/54 (28%)
		RhoGAP_MgcRacGAP	381..570	CDD:239847	52/207 (25%)
Arhgap21	XP_006497601.1	PDZ_signaling	55..162	CDD:238492
		PH_ARHGAP21-like	938..1047	CDD:269955	17/120 (14%)
		RhoGAP_ARHGAP21	1150..1345	CDD:239860	56/228 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910