DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tum and ARHGAP9

DIOPT Version :9

Sequence 1:	NP_610912.2	Gene:	tum / 36538	FlyBaseID:	FBgn0086356	Length:	625	Species:	Drosophila melanogaster
Sequence 2:	NP_001306779.2	Gene:	ARHGAP9 / 64333	HGNCID:	14130	Length:	750	Species:	Homo sapiens

Alignment Length:	664	Identity:	125/664 - (18%)
Similarity:	207/664 - (31%)	Gaps:	251/664 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 DLRRCMQVLTDGTPEEEFLRFLRMFEQYHEKCAG-----------------------------YA 46
            |||||.:....| |....|:.|..:||:.:..:|                             ..
Human   196 DLRRCPRSPPPG-PACPLLQRLDAWEQHLDPNSGRCFYINSLTGCKSWKPPRRSRSETNPGSMEG 259

  Fly    47 AETARIQNEL----------DKSLTKMGDLEGKLFHARRIIDME---IKARRQ----AEHERDAM 94
            .:|.:..|::          |....:..|.:|.|..::|...::   ::|.|.    .:...:..
Human   260 TQTLKRNNDVLQPQAKGFRSDTGTPEPLDPQGSLSLSQRTSQLDPPALQAPRPLPQLLDDPHEVE 324

  Fly    95 ESKIMAVADLLRHERNLNNE--------TRDKLAFLH----TLPSSRKRKSLNAVREDKSYGDIN 147
            :|.::.:..:.:..|.|...        |.:.|.|..    |.|||             .:|...
Human   325 KSGLLNMTKIAQGGRKLRKNWGPSWVVLTGNSLVFYREPPPTAPSS-------------GWGPAG 376

  Fly   148 STGSLLSDL---SITH-----SEDDFLDVRTSKS-----------------------------WR 175
            |......||   ::.|     |..:.|.:||...                             |.
Human   377 SRPESSVDLRGAALAHGRHLSSRRNVLHIRTIPGHEFLLQSDHETELRAWHRALRTVIERLVRWV 441

  Fly   176 EHRPSLPKNQIPSVGNKRSRLSTGLNGSMSGTTPTTGKSRRSSVGIGVEQHTVDVGQGAERFCAT 240
            |.|...|..:....|::.:.|...|:||        |.:..|:            |:..|.
Human   442 EARREAPTGRDQGSGDRENPLELRLSGS--------GPAELSA------------GEDEEE---- 482

  Fly   241 TKVTIPQDGQGVIRAESTIESLPVIAGNERIG-----DGLSSTPRRSVLKE--ATAPPLTPVNAM 298
                           ||.:.|.|::..:.|..     :|......|:.||.  |..|||
Human   483 ---------------ESELVSKPLLRLSSRRSSIRGPEGTEQNRVRNKLKRLIAKRPPL------ 526

  Fly   299 APHVVAESGTPLQHRPLMRNHTFSQKTFLRGDNCVQCQKRIRFGAVGLRCRDCPVRCHIDCRYLL 363
                     ..||.|.|:|:..|.            ||                          |
Human   527 ---------QSLQERGLLRDQVFG------------CQ--------------------------L 544

  Fly   364 TVSCVPQTGTPTTKTMTGYVTDFAPSIAPMIPALIVHCVNEIEARGLTEVGLYRLSSSEREYKAL 428
            ...|..:..|                    :|:.:..|:..::.|||...|:||:|.:....:.|
Human   545 ESLCQREGDT--------------------VPSFLRLCIAAVDKRGLDVDGIYRVSGNLAVVQKL 589

  Fly   429 KEQFLRGKATPHLGN--------------------TDIYVLCCCVKDFLRSLTEPLIPTSQWKDF 473
            :....|.:|....|.                    .||:|:...:|.|||.|.:||:|......|
Human   590 RFLVDRERAVTSDGRYVFPEQPGQEGRLDLDSTEWDDIHVVTGALKLFLRELPQPLVPPLLLPHF 654

  Fly   474 ANAVQNPDTKTAQDMLVKSVKQLPQANRDTLAFLILHFQR-IAQCPVVLMPIDNISLIFGPTIV- 536
            ..|:...:::.....:.:.:..:|:.|.|||.:|:.|..| ||......|...|:.::||||:.
Human   655 RAALALSESEQCLSQIQELIGSMPKPNHDTLRYLLEHLCRVIAHSDKNRMTPHNLGIVFGPTLFR 719

  Fly   537 -GYSTPDPDQHAIY 549
             ...|.||..||:|
Human   720 PEQETSDPAAHALY 733

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tum	NP_610912.2	C1	319..367	CDD:237996	4/47 (9%)
tum	NP_610912.2	RhoGAP_MgcRacGAP	381..570	CDD:239847	48/192 (25%)
ARHGAP9	NP_001306779.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	120..187
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	242..319		9/76 (12%)
		Lipid binding	342..345		0/2 (0%)
		Lipid binding	397..399		0/1 (0%)
		Lipid binding	432..669		63/348 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	446..488		12/80 (15%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910