Protein Alignment tum and ARHGAP21

DIOPT Version :9

• Sequence 1: NP_610912.2
• Gene: tum / 36538
• FlyBaseID: FBgn0086356
• Length: 625
• Species: Drosophila melanogaster
• Sequence 2: XP_011517904.1
• Gene: ARHGAP21 / 57584
• HGNCID: 23725
• Length: 1992
• Species: Homo sapiens
• Alignment Length: 614
• Identity: 133/614 - (21%)
• Similarity: 224/614 - (36%)
• Gaps: 162/614 - (26%)

  Fly    84 RRQAEHERDAMESKIMAVADLLRHERN------LNNETRD-KLAFLHTLPSSRKRKSLNAVREDK 141
            |||..|:.:::....:......:.||:      |::...| ||:|.|.    ...|.:......|
Human   887 RRQLSHDHESVGPPSLDAQPNSKTERSKSYDEGLDDYREDAKLSFKHV----SSLKGIKIADSQK 947

  Fly   142 SYGDINSTGSLLSDLSITHSEDDFLDVR---TSKS---------WREHRPSLPKNQIPSVGNKRS 194
            |..|..|.....|::....:::.:|..|   |.|.         |::....|..:.:....:||.
Human   948 SSEDSGSRKDSSSEVFSDAAKEGWLHFRPLVTDKGKRVGGSIRPWKQMYVVLRGHSLYLYKDKRE 1012

  Fly   195 RLSTGLNGSMSGTTPTTGKSRRSSVGIGVEQHTVDVGQGAER----FCATTKVTIPQDGQGVIRA 255
            :           |||:     .....|.|....:|:.....:    |..||     .|.:.:.:|
Human  1013 Q-----------TTPS-----EEEQPISVNACLIDISYSETKRKNVFRLTT-----SDCECLFQA 1056

  Fly   256 ESTIESLPVIAG-------NE-------------RI---------GDGLSSTPRRSV-----LKE 286
            |...:.|..|..       ||             ||         .:.|..|||:|:     |..
Human  1057 EDRDDMLAWIKTIQESSNLNEEDTGVTNRDLISRRIKEYNNLMSKAEQLPKTPRQSLSIRQTLLG 1121

  Fly   287 ATAPPLTPVNAMAPHVVAESGTPLQHRPLMRNHTFSQK---TFLRGDNCVQC----QKRIRFGAV 344
            |.:.|.|    .:||...|..   :.:.|.::.|...|   |:.:|...:..    :|....|..
Human  1122 AKSEPKT----QSPHSPKEES---ERKLLSKDDTSPPKDKGTWRKGIPSIMRKTFEKKPTATGTF 1179

  Fly   345 GLRCRDCPVRCHIDCRYLLTVSCVPQTGTPTTKTMTGYVTDFAPSIAPMIPALIVHCVNEIEARG 409
            |:|..||| ..|.: ||                                ||.::..|...:|.||
Human  1180 GVRLDDCP-PAHTN-RY--------------------------------IPLIVDICCKLVEERG 1210

  Fly   410 LTEVGLYRLSSSEREYKALKEQFLRGKATPHLGN---TDIYVLCCCVKDFLRSLTEPLIPTSQWK 471
            |...|:||:..:.....:::|:..:|.|...:.:   .|:.|:...:|.|.|.|.|||....::.
Human  1211 LEYTGIYRVPGNNAAISSMQEELNKGMADIDIQDDKWRDLNVISSLLKSFFRKLPEPLFTNDKYA 1275

  Fly   472 DFANAVQNPDTKTAQDMLVKSVKQLPQANRDTLAFLILHFQRIAQ-CPVVLMPIDNISLIFGPTI 535
            ||..|.:..|.......|.:.:..||:.:.:||.||..|.:.:|: .....|...|::::||||:
Human  1276 DFIEANRKEDPLDRLKTLKRLIHDLPEHHYETLKFLSAHLKTVAENSEKNKMEPRNLAIVFGPTL 1340

  Fly   536 VGYS--------TPDPDQHAIYTEV-------FTQKQVMKALLELPVSFWEQYIVIDPTRTP--- 582
            |..|        |..|||:.|...:       ||::..     |.|::..::...:|....|
Human  1341 VRTSEDNMTHMVTHMPDQYKIVETLIQHHDWFFTEEGA-----EEPLTTVQEESTVDSQPVPNID 1400

  Fly   583 --ATVIKRV---PSNKNDLLSLYATPFKG 606
              .|.|.|.   |.:.:|..:..:|..||
Human  1401 HLLTNIGRTGVSPGDVSDSATSDSTKSKG 1429

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tum	NP_610912.2	C1	319..367	CDD:237996	14/54 (26%)
		RhoGAP_MgcRacGAP	381..570	CDD:239847	52/207 (25%)
ARHGAP21	XP_011517904.1	PDZ_signaling	48..155	CDD:238492
		PH_ARHGAP21-like	967..1076	CDD:269955	22/129 (17%)
		PH	968..1073	CDD:278594	22/125 (18%)
		RhoGAP_ARHGAP21	1178..1373	CDD:239860	56/228 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910