DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tum and arap1a

DIOPT Version :9

Sequence 1:	NP_610912.2	Gene:	tum / 36538	FlyBaseID:	FBgn0086356	Length:	625	Species:	Drosophila melanogaster
Sequence 2:	XP_700481.5	Gene:	arap1a / 571767	ZFINID:	ZDB-GENE-030131-6226	Length:	1092	Species:	Danio rerio

Alignment Length:	285	Identity:	66/285 - (23%)
Similarity:	114/285 - (40%)	Gaps:	54/285 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   338 RIRF----GAVGLRCRDCPVRCHIDCR--YLLTVSCVPQ-TGTPTTKTMTGYVTDFAPSIAPMIP 395
            |::|    ||:.|..|..|:....|.|  ::...:|:.| :|....:.....:||..      ||
Zfish   622 RLKFSNTGGAIVLVWRGGPLHLQADRRPHFVGWQTCIQQKSGAGNERLSQQQLTDLG------IP 680

  Fly   396 ALIVHCVNEIEARGLTEVGLYRLSSSEREYKALKEQFLRGKATPHLGNTD--IYVLCCCVKDFLR 458
            ..|..|::.|...||...|:||||........|.::|.....|.....::  ::.:...:|.|||
Zfish   681 VTIDRCLDHITRYGLLSPGIYRLSGINSHVTKLLDKFQNNARTVTWCESEYSVHDVANTLKRFLR 745

  Fly   459 SLTEPLI----PTSQWKDFANAVQNPDTKTAQDMLVKSVKQLPQANRDTLAFLILHFQRIAQCPV 519
            .:...:.    ..:.|...|......:......:|:.:   ||..||:.|..||.|.    .|..
Zfish   746 EVKGGVFNGQENNASWLRVAGLEDGCEKIQRYQILLSN---LPDINREALKVLIHHL----VCVQ 803

  Fly   520 VL-----MPIDNISLIFGPTIVGYSTPDPDQHAIYTEVFTQKQVMKALLELPVSFWE-------- 571
            .|     |.|.|:.::||||:  :.|...|.        |..||::.|::...|.::
Zfish   804 NLSNENQMTIRNLGIVFGPTL--FQTDGKDT--------TASQVVEELIQNYCSIFKVSESELEK 858

  Fly   572 ----QYIVIDPTRTPATVIKRVPSN 592
                ..:::|..::..|:| |.||:
Zfish   859 QLNMMSVILDNHKSQKTLI-RTPSS 882

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tum	NP_610912.2	C1	319..367	CDD:237996	9/34 (26%)
tum	NP_610912.2	RhoGAP_MgcRacGAP	381..570	CDD:239847	48/199 (24%)
arap1a	XP_700481.5	PH	56..147	CDD:278594
		PH-like	57..149	CDD:302622
		PH-like	171..251	CDD:302622
		ArfGap	266..378	CDD:279720
		PH-like	463..566	CDD:302622
		PH	465..567	CDD:278594
		PH-like	580..660	CDD:302622	10/37 (27%)
		RhoGAP_ARAP	665..845	CDD:239850	47/202 (23%)
		UBQ	887..968	CDD:294102
		PH-like	973..1090	CDD:302622
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910