DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tum and arhgap45b

DIOPT Version :9

Sequence 1:	NP_610912.2	Gene:	tum / 36538	FlyBaseID:	FBgn0086356	Length:	625	Species:	Drosophila melanogaster
Sequence 2:	XP_005170570.1	Gene:	arhgap45b / 555849	ZFINID:	ZDB-GENE-071213-2	Length:	1136	Species:	Danio rerio

Alignment Length:	658	Identity:	137/658 - (20%)
Similarity:	235/658 - (35%)	Gaps:	148/658 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 DLRRCMQVLTDGTPEEEFLRFLRMFEQYHEKCAGY-AAETA--RIQNELDKSLTKMGDLEGKLFH 72
            :|||..||                   |..:|..| .|.||  |.:.|...:.||..|.:.:|
Zfish   431 NLRRAKQV-------------------YMTRCEEYDKARTAANRAEEEGGSATTKTLDKKKRL-- 474

  Fly    73 ARRIIDMEIKARRQAE-----------------HERDAMESKIM-AVADLLRH-ERNLNNETRDK 118
                   |.:||.:||                 .|.:.|:..:: .:.::::. ::.:.:.|...
Zfish   475 -------EEEARNKAEEAEATYRTCIADAITQHQELEHMKVTVLRGIQEVIKQTDQTIRSATISY 532

  Fly   119 LAFLHTLPSSRKRKSLNAVREDKSYGDINSTGSLLSDLSI-----THSEDDFLDVRTSKSWREHR 178
            ...:|....:............|.|......|:.:.||.:     ||.|  |.....|...:..|
Zfish   533 YQIMHMQTVALPVHYQTLCESSKQYDPGQQYGTHVKDLQMSEEPETHYE--FEAYSASSVQQSVR 595

  Fly   179 PSLPKNQIPSVGNKRSRLSTGLNGSMSGTTP---------TTGKSRRSSVGIGVEQHTVDVGQGA 234
            |........:..:.....:.|..|..|.:..         .|.||..|:|.   :..:|..|.|.
Zfish   596 PRTDSANAEAQSSAEVPQTAGETGDTSSSQKDDQKRARGHMTHKSWGSTVS---DTDSVGGGSGL 657

  Fly   235 ERFCATTKVTIPQDGQGVIRAESTIESLPVIAGNERIGDGLSSTPRRSVLKEATAPPL-TP-VNA 297
            |.         |....|.|...:...|...::.||.|.:           |:|..... || :|.
Zfish   658 ES---------PTTSTGDISKMTRTSSTGTMSSNEDIDE-----------KDANVTSFETPNING 702

  Fly   298 MAPHVVAESGTPLQHRPLMR-NHTFSQKTFLRGDNCVQCQKRIRFGAVGLRCRDCPVRCHIDCRY 361
            :.|.:|..:| |.::..|.: ..|...:.......|.:|...:.|  .|..|.:|.:.||..|..
Zfish   703 IEPEIVVPTG-PFRNIGLSKAAQTHKLRKLRSPSKCRECDSYVYF--QGAECEECFLACHKRCLE 764

  Fly   362 LLTVSCVPQTGTPTTKTMTGYVTDFAPSIAPM-------IPALIVHCVNEIEARGLTEVGLYRLS 419
            .:.:.|       ..|.:.|.:..|......:       ||.:|..|:.|||.|.|...|:||::
Zfish   765 TIAIQC-------GHKKLQGRLQLFGQDFLQVSSNSPDGIPFIIKKCIAEIERRALRMKGIYRVN 822

  Fly   420 SSEREYKALKEQFLRGKATPHLGNTDIYVLCCCVKDFLRSLTEPLIPTSQWKDF----------- 473
            ..:...:.|.:.|..||....|..:..:.:...:|.:||.|.||::|...:...
Zfish   823 GVKTRVEKLCQAFENGKELVELSQSSPHDISNVLKLYLRQLPEPIMPFRLYNSLMGLAKESLAVV 887

  Fly   474 ----ANAVQNPD-----TKTAQDMLV------KSVKQLPQANRDTLAFLILHFQRIAQCPVVL-- 521
                |::.:.||     .:|..::||      ..:|:||:.|..||.:|..|.:|||:    |
Zfish   888 GPEGADSGKGPDLMDLGPETDPELLVLVDRLKNLLKELPKPNTATLRYLARHLRRIAE----LED 948

  Fly   522 ---MPIDNISLIFGPTIVGYSTPDPDQHAIYTEVFTQKQVMKALLELPVSFWEQYIVIDPTRTPA 583
               |...|:.::|||:::   .|.|....:.............::|..:.|:......:.:| ||
Zfish   949 DNKMSPSNLGIVFGPSLM---RPRPSGATVSLSSLVDYPYQARIVETLIVFYPSIFQSESSR-PA 1009

  Fly   584 TVIKRVPS 591
            :...|..|
Zfish  1010 SSSTRTQS 1017

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tum	NP_610912.2	C1	319..367	CDD:237996	10/47 (21%)
tum	NP_610912.2	RhoGAP_MgcRacGAP	381..570	CDD:239847	52/226 (23%)
arhgap45b	XP_005170570.1	BAR	309..553	CDD:299863	26/149 (17%)
		C1	724..770	CDD:197519	10/47 (21%)
		RhoGAP	782..996	CDD:295372	51/220 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910