DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tum and Arhgap27

DIOPT Version :9

Sequence 1:	NP_610912.2	Gene:	tum / 36538	FlyBaseID:	FBgn0086356	Length:	625	Species:	Drosophila melanogaster
Sequence 2:	NP_001192165.1	Gene:	Arhgap27 / 544817	MGIID:	1916903	Length:	869	Species:	Mus musculus

Alignment Length:	590	Identity:	126/590 - (21%)
Similarity:	215/590 - (36%)	Gaps:	183/590 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 TPEEEFL--------RFLRMFEQYHEKCAGYAAETARIQNELDKSLTKMGDLEGKLFHARRIIDM 79
            ||:::.|        :::|: |..|.|...|..|.:.:|.||.:                    :
Mouse   404 TPDKQMLYTNQFTQEQWVRL-EDQHGKPYFYNPEDSSVQWELPQ--------------------V 447

  Fly    80 EIKARRQAEHERDAMESKIMAVADLLRHERNLNNETRDKLAFLHTLPSSRKRKSLNAVREDKSYG 144
            .|.|.|..  .:.:.:|...|.|.  ..|..:  :|.||...||...:..|.|.|.......|:.
Mouse   448 PIPAPRSV--RKSSQDSDTPAQAS--PPEEKI--KTLDKAGVLHRTKTVDKGKRLRKKHWSTSWT 506

  Fly   145 DINSTGSLLSDLSITHSEDDFLDVRTSKSWREHRPSLPKNQIPSVGNKRSRLST-----GLNGSM 204
            .:.  |.:|:         .|.|.:||.:....:|              |:|||     .|.|:.
Mouse   507 VLE--GGVLT---------FFKDSKTSAAGGLRQP--------------SKLSTPEYTVELKGAS 546

  Fly   205 SGTTPTTGKSRRSSVGI----GVE---QHTVDVGQGAERFCATTKVTIPQD----GQGVIRAEST 258
            ....|....|:::.:.:    |.|   ||      .:|...:|....|.:.    ...:::.|..
Mouse   547 LSWAPKDKSSKKNVLELRSRDGSEYLIQH------DSEAIISTWHKAIAEGISELSADLLQGEEG 605

  Fly   259 IESLPVIAGNERIGDGLSSTPRRSVLKEATAPPLTP--VNAMAPHVVAESGTPLQHRPLMRNHTF 321
            ..|......:||:|    |.....|.:.|.:|.|:|  :.:....|..:....||.||.:::
Mouse   606 EPSSADFGSSERLG----SWREEDVRQNAASPSLSPGGLESDLSRVRHKLRKFLQRRPTLQS--- 663

  Fly   322 SQKTFLRGDNCVQCQKRIRFGAVGLRCRDCPVRCHIDCRYLLTVSCVPQTGTPTTKTMTGYVTD- 385
                                      .||                             .||:.|
Mouse   664 --------------------------LRD-----------------------------KGYIKDQ 673

  Fly   386 -FAPSIAPM-------IPALIVHCVNEIEARGLTEVGLYRLSSS-----EREYKALKEQFL---R 434
             |..::|.:       :|..:..|:..:|||||...||||:|.:     :..||...::.|   .
Mouse   674 VFGCALAQLCERERSPVPRFVQQCIRTVEARGLDIDGLYRISGNLATIQKLRYKVDHDERLDLDD 738

  Fly   435 GKATPHLGNTDIYVLCCCVKDFLRSLTEPLIPTSQWKDFANAVQNPDTKTAQDMLVKSVKQLPQA 499
            |:.      .|::|:...:|.|.|.|.|||.|.|.:..|..|::..|.......:...|:.||..
Mouse   739 GRW------EDVHVITGALKLFFRELPEPLFPFSHFHQFIAAIKLQDPAQRSRCVRDLVRTLPAP 797

  Fly   500 NRDTLAFLILHFQRIAQCPVV------LMPIDNISLIFGPTIVGYSTPDPDQHAIYTEVFTQKQV 558
            |:|||..||.|.     |.|:      .|.:.|::::||||::   .|:.::.::...:..|.||
Mouse   798 NQDTLRLLIQHL-----CRVIEHGEQNRMTVQNVAIVFGPTLL---RPEMEEASMPMTMVFQNQV 854

  Fly   559 MKALL 563
            ::.:|
Mouse   855 VELIL 859

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tum	NP_610912.2	C1	319..367	CDD:237996	2/47 (4%)
tum	NP_610912.2	RhoGAP_MgcRacGAP	381..570	CDD:239847	58/206 (28%)
Arhgap27	NP_001192165.1	SH3_ARHGAP27	10..66	CDD:213002
		PRK12323	<68..249	CDD:237057
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	104..134
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	208..300
		PRP40	241..>328	CDD:227435
		WW	248..278	CDD:395320
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	331..401
		WW	418..445	CDD:395320	8/27 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	443..477		9/59 (15%)
		PH_ARHGAP9-like	480..594	CDD:270053	29/144 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	623..642		5/18 (28%)
		RhoGAP_ARHGAP27_15_12_9	675..861	CDD:239868	55/199 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910