DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tum and RhoGAP92B

DIOPT Version :9

Sequence 1:	NP_610912.2	Gene:	tum / 36538	FlyBaseID:	FBgn0086356	Length:	625	Species:	Drosophila melanogaster
Sequence 2:	NP_001287417.1	Gene:	RhoGAP92B / 42371	FlyBaseID:	FBgn0038747	Length:	740	Species:	Drosophila melanogaster

Alignment Length:	553	Identity:	120/553 - (21%)
Similarity:	207/553 - (37%)	Gaps:	120/553 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   141 KSYGDINSTGSLLSDLSITHSEDDFLDVRTSKSWREHRPSLPKNQIPSVGNKRSRLSTGLNGSMS 205
            :.:..|......||..|.:.|:|..|:.      .|.:....::.|..:..|...||.| .||.|
  Fly     3 RQFAKIKIAAENLSRSSKSDSKDSELEA------IERQVDRYRDTIEKIVRKLPALSGG-GGSGS 60

  Fly   206 GTTPTTGKSRRSSVGIGVEQHTVDVGQGAERF------------CATTKVTIPQDGQGVIRAEST 258
            |::....|..:.:....:.|   .:.:.|:..            |...:.|:   .:.:|.:|..
  Fly    61 GSSEEQDKRTKKNSHYKIAQ---ALDESAKELPKDMPLQKVLANCGELEKTM---AECIIESELE 119

  Fly   259 IESLPVIAGNERIGDGLS------STPRRSV---LKEATAPPLTPVNAMAPHVVAESGTPLQHRP 314
            .|:..|    .|:.:.|.      ||.:|:|   |:|.|       :....|   |:...|:...
  Fly   120 TEAKVV----RRLKNILDKEIQEISTLKRNVSRTLQEYT-------SLKRSH---EAAIRLEEPA 170

  Fly   315 LMRNHTFSQ--------------------KTFLRGDNCVQCQKRIRFGAVGLRCRDCPVRCHIDC 359
            ...||..||                    :...:.|..|.|   ||...:..|........|::.
  Fly   171 AKVNHIKSQQEECELKLEKERDAWAAQMLELIAKEDEIVSC---IRDYVLNQRNYHERALQHVNA 232

  Fly   360 RYLLTVSCVPQTGTPTTKTMTG-----YVTDFAPSIAPMIPALIVHCVNEIEARGLTEVGLYRL- 418
                :::.:..|...|.|:..|     ::|.....|: .|..|...|:.|   .||.|.||.|:
  Fly   233 ----SLARIQDTIQGTEKSRFGTSLKEHLTSTNREIS-YIVELCCCCLLE---HGLEEEGLLRVG 289

  Fly   419 --SSSEREYK-ALKEQFLRGKATP-HLGNTDIYVLCCCVKDFLRSLTEPLIPTSQWKDFANAVQN 479
              |:..|..| ||:.|.::   || .|...|.:|:...:|.:||.|.|||:..:.:|||....:.
  Fly   290 CASTKLRRMKHALEAQHVK---TPLPLDYQDPHVIGSILKLYLRELPEPLLTYNLYKDFIRIAER 351

  Fly   480 PDTKTAQDMLVKSVKQLPQANRDTLAFLILHFQRIAQCPVVL--MPIDNISLIFGPTI----VGY 538
            ......:..:...:.:||:.|...|.:| ..|..|.|....|  |...|::::..|.:    :..
  Fly   352 HSEAERKTEIKAILTKLPKENYANLRYL-TRFLSIVQQRSALNKMSSQNLAIVMSPNMLWPRIDK 415

  Fly   539 STPDPDQHAIYTEVFTQKQVMKALLELPVSFWEQYIVIDPTRTPATVIK-------RVPSN---- 592
            |:..|   |.|............::||.:|.|: |..|.......|:.|       :..||
  Fly   416 SSNAP---ADYIGQVNSSSAANIIVELLISQWD-YFFIGEVEFYLTLQKQKLFVEGKSKSNSSNE 476

  Fly   593 ---KNDLLSLYATPFKGGTIKKRKFYG-TPPAS 621
               :|| ..:..:| :.||::::|... :||.:
  Fly   477 NLDRND-SEVMESP-RYGTLRRQKANAPSPPTT 507

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tum	NP_610912.2	C1	319..367	CDD:237996	10/67 (15%)
tum	NP_610912.2	RhoGAP_MgcRacGAP	381..570	CDD:239847	53/204 (26%)
RhoGAP92B	NP_001287417.1	BAR	27..257	CDD:299863	47/263 (18%)
RhoGAP92B	NP_001287417.1	RhoGAP_nadrin	245..452	CDD:239851	57/218 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910