DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tum and pik3r2

DIOPT Version :9

Sequence 1:	NP_610912.2	Gene:	tum / 36538	FlyBaseID:	FBgn0086356	Length:	625	Species:	Drosophila melanogaster
Sequence 2:	NP_997987.2	Gene:	pik3r2 / 404211	ZFINID:	ZDB-GENE-040309-1	Length:	724	Species:	Danio rerio

Alignment Length:	294	Identity:	82/294 - (27%)
Similarity:	114/294 - (38%)	Gaps:	61/294 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   321 FSQKTFLRGD---NCVQCQKRIRFGAVGLRCRDCPVRCHIDCRYLLTVSCVPQTGTPTTKTMTGY 382
            |:::|..|||   ..||     ..|.|.|....|..|..      ..:..||:. .||.......
Zfish    59 FNERTKQRGDFPGTYVQ-----YVGPVKLSAPYCQPRSQ------RPLPAVPRP-EPTASLQVVP 111

  Fly   383 VTDFA-----PSIAPMIPALIVHCVNEIEARGLTEVGLYRLSSSEREYKALKE-QFLRGKATPHL 441
            ..|..     |..||  |.|| ..:..:|..||....|||.|:|:.:..:|.| |.|      .:
Zfish   112 DLDLTKQFMHPETAP--PNLI-KLIEAVERSGLDCRTLYRTSASDNQRPSLSELQDL------DV 167

  Fly   442 GNTDIYVLCCCVKDFLRSLTEPLIPTSQWKDFANAVQ-NPDTKTA------QDMLVKSVKQLPQA 499
            |..||:.|...|..:|:.|..|:||...:.|...||| ..|..:.      |.:|.|  .::|..
Zfish   168 GQWDIHALSEAVIRYLQDLPAPIIPPCVYTDLQAAVQLESDVPSVRRRELLQQVLDK--PEVPLQ 230

  Fly   500 NRDTLAFLILHFQRIAQCPVVL-MPIDNISLIFGPTI----VGYSTPDPDQHAIYTEVFTQKQVM 559
            |..||.:|:.|..::.|..... :.|..:..||||.:    |..|..|        |.|....|.
Zfish   231 NLLTLHYLLQHLDKVCQSAEQNGLDIYTLGQIFGPLLFRGPVSGSEED--------EAFPAAAVE 287

  Fly   560 KALLELPVSFWEQYIVIDPTRTPATVIKRVPSNK 593
            :.|||   ..|||    :|  ||..:..:.|..|
Zfish   288 RLLLE---RIWEQ----EP--TPPALPPKPPKAK 312

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tum	NP_610912.2	C1	319..367	CDD:237996	12/48 (25%)
tum	NP_610912.2	RhoGAP_MgcRacGAP	381..570	CDD:239847	58/206 (28%)
pik3r2	NP_997987.2	SH3_PI3K_p85beta	6..79	CDD:212842	7/24 (29%)
		RhoGAP	113..298	CDD:295372	61/210 (29%)
		SH2_nSH2_p85_like	326..433	CDD:198195
		PI3K_P85_iSH2	437..596	CDD:293063
		iSH2_PIK3R2	438..598	CDD:214019
		SH2_cSH2_p85_like	616..720	CDD:198184
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910