DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tum and arhgap4a

DIOPT Version :9

Sequence 1:	NP_610912.2	Gene:	tum / 36538	FlyBaseID:	FBgn0086356	Length:	625	Species:	Drosophila melanogaster
Sequence 2:	NP_956738.1	Gene:	arhgap4a / 393416	ZFINID:	ZDB-GENE-040426-1229	Length:	917	Species:	Danio rerio

Alignment Length:	669	Identity:	132/669 - (19%)
Similarity:	229/669 - (34%)	Gaps:	171/669 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 ASFDDLRRCMQVLTDGTPEE---------EFLRFL------------RMFEQYHEKCAGYAAETA 50
            :|...:..|.|||...|.:|         .:...|            |:.::..|.|........
Zfish    83 SSHQSVVNCWQVLLAQTRQESRDHSILSDSYSNILPQQLSHCIEHAQRLAKRSREICTLLQDGLL 147

  Fly    51 RIQNELDKSL-------TKMGDLEGKLFHARRIIDMEIKARRQA----EHERDAMESKIMAVADL 104
            ::..||..:|       |:....||||   :..:.:|.|.::.|    |.:.:..:.|:..:...
Zfish   148 KVTIELHTTLKTYYQYYTEFLSAEGKL---KEAVKLEEKQKQSASKKMERQIEKRQCKVQEIQLK 209

  Fly   105 LRHERN---LN----NETRDK--------------LAF-------LHTLPSSRKRKSLNAVREDK 141
            ....||   ||    |...:|              |.:       ||...|||:....|.
Zfish   210 CTKARNDYLLNLAAANACMNKYYLQDLSTLIDCCDLGYHQSISKVLHFYLSSRQWAQQNL----- 269

  Fly   142 SYGDINSTG-----SLLSDLSITHSEDDFLDVRTSK-----SWREHRPSLPKNQIPSVGNKRSRL 196
                  |||     :.:|:||.:...|..:....|.     .::.|  ....:|:..|..|...:
Zfish   270 ------STGMRQLETTVSELSQSQDRDTLMQFNNSAFCLPLRFQYH--PYEGDQVVEVSAKCEMM 326

  Fly   197 STGLNGSMSGTTPTTGKSRRSSVGIGVEQHTVDVGQGAERFCATTKVTIPQDGQGVIRAESTI-E 260
            |..:      |.....:||.|||.:.||                      :.|:.:..|:|:| |
Zfish   327 SELV------TRVQQLQSRLSSVTLEVE----------------------ESGKLLQSAQSSILE 363

  Fly   261 SLPVIA---------------GNERIGDGLSST-PRRSVLKEATAPPLTPVNAMAPHVVAESGTP 309
            ||..||               ||..:....:.| .||:.|.:|.:...|.|.   .|:...|
Zfish   364 SLAEIAFGSTPDFPSSPSSPEGNSDVSANKNFTLKRRASLPDAESLYFTKVR---DHLCNSS--- 422

  Fly   310 LQHRPLMRNHTFSQKTFLRGDNCVQCQKRIRFGAVGLRCRDCPVRCHIDCRYLLTVSCVPQTGTP 374
                  :|:...::...|:    |..||...|.....|.|......|             :...|
Zfish   423 ------LRSKLEAKHDLLK----VAIQKAESFDGNHTRTRSKRSVRH-------------KKSNP 464

  Fly   375 ----TTKTMTGYVTDFAPSIAPMIPALIVHCVNEIEARGLTEVGLYRLSSSEREYKALKEQFLRG 435
                ..|...|.:..:..:...:|||::..|:..|...||...||:|:..|:.....||:.|.:|
Zfish   465 GSQINQKLFNGDLLSYIQASGQLIPAVVESCIRFINLNGLHHEGLFRVPGSQMVVNQLKDAFEKG 529

  Fly   436 KATPHLGNTDIYVLCCCVKDFLRSLTEPLIPTSQWKDFANAVQNPDTKTAQDMLVKSVKQLPQAN 500
            .........|:..:...:|.:.|.|.:||.|...:.......|..|.......|...|...|.:.
Zfish   530 DDPLTDERCDMDSVAGVLKLYFRGLEKPLFPEDSYDQLMECGQIDDETKKVTQLKLIVSSYPPSL 594

  Fly   501 RDTLAFLILHFQRIAQ-CPVVLMPIDNISLIFGPTIV-GYSTPDPDQ----HAIYTEVFTQ-KQV 558
            ...:.:|......::| ....:|...|:::.|||::| |.:..|..:    :|:...:..: :.:
Zfish   595 IIVMRYLFAFLHHVSQYSDENMMQPYNLAVCFGPSLVRGPNNGDAAELQRINALVKSIIIRHESI 659

  Fly   559 MKALLELPVSFWEQYIVID 577
            ..:..|||...:|:.:.::
Zfish   660 FPSQSELPGPVYEKCMTLE 678

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tum	NP_610912.2	C1	319..367	CDD:237996	8/47 (17%)
tum	NP_610912.2	RhoGAP_MgcRacGAP	381..570	CDD:239847	42/195 (22%)
arhgap4a	NP_956738.1	F-BAR_srGAP	27..252	CDD:153340	31/171 (18%)
		RhoGAP_srGAP	471..655	CDD:239848	40/183 (22%)
		SH3_srGAP4	704..758	CDD:212889
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910