Protein Alignment tum and ARHGAP40

DIOPT Version :9

• Sequence 1: NP_610912.2
• Gene: tum / 36538
• FlyBaseID: FBgn0086356
• Length: 625
• Species: Drosophila melanogaster
• Sequence 2: NP_001157903.1
• Gene: ARHGAP40 / 343578
• HGNCID: 16226
• Length: 674
• Species: Homo sapiens
• Alignment Length: 570
• Identity: 105/570 - (18%)
• Similarity: 185/570 - (32%)
• Gaps: 166/570 - (29%)

  Fly    13 RRCMQVLT-------------DGTPEEEFLRFLRMFEQYHEK----CA---------GYAAETAR 51
            |||.|...             |..|::..||.       |..    |:         |:..|..:
Human    34 RRCAQRWADLGCSSGPSSGRMDQLPQKNLLRL-------HPAGSAGCSTGVESSSMDGFWMEVEQ 91

  Fly    52 IQNELDKSLTKMGDLEGKLFHARRIIDMEIKARRQAEHERDAMESKIMAVADLL-------RHER 109
            ||...:......|..||:|                .|.|.::...:...::.||       .|:.
Human    92 IQQRDELREEDSGGNEGQL----------------PEGEAESQWLQDTGLSGLLGGLGLDGDHQE 140

  Fly   110 NLNNETRDKLAF----LHTLPSSRKRKSLNAVREDKSYGDINSTGSLLSDLSITHSEDDFLDVRT 170
            .|:..|:.::|.    |.....|.:|:....||:.:....:.::|.:.|:    :.:......:.
Human   141 LLSTLTQTQVAAVCRRLDIYARSVRRQHKTPVRDVRDVFGVFNSGKMSSE----NGDSGMKGAQL 201

  Fly   171 SKSWREHRPSLPKNQIPSVGNKRSRLSTGLNGSMSGTTPTTGKSRRSSVGIGVEQHTVDVGQGAE 235
            |....:..|:.....:.....:....:  ::.:.|.......:..|.|.|          |..|.
Human   202 SSGASKFPPAAEPGGLQEQAGREEAFN--MDSAYSEQAAVLLQRSRPSRG----------GTSAW 254

  Fly   236 RFCATTKVTIPQDGQGVIRAESTIESLPVIAGNERIGDGLSSTPRRSVLKEATAPPLTPVNAMAP 300
            ..|:..|.|:|:...||                .|||| ||....|.|      |.|..:...|
Human   255 GKCSLPKFTVPKGRLGV----------------TRIGD-LSLQDMRKV------PSLALIELTA- 295

  Fly   301 HVVAESGTPLQHRPLMRNHTFSQKTFLRGDNCVQCQKRIRFGAVGLRCRDCPVRCHIDCRYLLTV 365
             :....|..|:.                       .|..::.|...|....|:...::..:.:
Human   296 -LCDILGLDLKR-----------------------SKAGKWKAAETRLFGVPLDSLLEADHKV-- 334

  Fly   366 SCVPQTGTPTTKTMTGYVTDFAPSIAPMIPALIVHCVNEIEARGLTEVGLYRLSSSEREYKALKE 430
                   .|:|:             .|::...::.|   :|.|||...|:.|:..|:...|.|::
Human   335 -------LPSTQ-------------VPLVLQALLSC---LEKRGLDMEGILRVPGSQARVKGLEQ 376

  Fly   431 QFLRG--------KATPHLGNTDIYVLCCCVKDFLRSLTEPLIPTSQWKDFANAVQNPDTKTAQD 487
            :..|.        ....|...:|:      :|.|:|.|..||:.......||.....|:.|....
Human   377 KLERDFYAGLFSWDEVHHNDASDL------LKRFIRKLPTPLLTAEYLPAFAVVPNIPNLKQRLQ 435

  Fly   488 MLVKSVKQLPQANRDTLAFLILHFQR--IAQCPVVLMPIDNISLIFGPTI 535
            :|...:..||:.||:.|..| |.|.|  :|:.....|.:.|:|.:..|.:
Human   436 VLHLLILILPEPNRNALKAL-LEFLRKVVAREQHNKMTLRNVSTVMAPNL 484

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tum	NP_610912.2	C1	319..367	CDD:237996	4/47 (9%)
		RhoGAP_MgcRacGAP	381..570	CDD:239847	39/165 (24%)
ARHGAP40	NP_001157903.1	RhoGAP	319..532	CDD:295372	42/198 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910