DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tum and Arhgap32

DIOPT Version :9

Sequence 1:	NP_610912.2	Gene:	tum / 36538	FlyBaseID:	FBgn0086356	Length:	625	Species:	Drosophila melanogaster
Sequence 2:	XP_006510505.1	Gene:	Arhgap32 / 330914	MGIID:	2450166	Length:	2103	Species:	Mus musculus

Alignment Length:	666	Identity:	127/666 - (19%)
Similarity:	225/666 - (33%)	Gaps:	227/666 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 LTDGTPEEEFLRFLRMFEQYHEKCAGYAAET-----ARIQNELDKSLTKMG------DLEGKLFH 72
            ||||..||....|.:|....|.:...:..|.     .|.:.:.:::|:.|.      ::.|
Mouse    26 LTDGDEEEREESFRKMKSSIHSEEDDFVPELHRNVHPRERPDWEETLSAMARGADVPEIPG---- 86

  Fly    73 ARRIIDMEIK-----ARRQAEHERDAMESKIMAVADLLRHERNLNNETRDKLAFLHTLPSSRKR- 131
                 |:.:|     |..:.:|.:.:....:|...:                  :|.||.::..
Mouse    87 -----DLTLKSCGSTASTKVKHVKKSTPPGLMGCDN------------------IHRLPFTKGHF 128

  Fly   132 -KSLNAVR---EDKSYGDINSTGSLLSDLSITHSEDDFLD--------------VRTSKSWREHR 178
             |......   |:..:|.|        .||::..:::.:.              ....|||...|
Mouse   129 PKMAECAHFHYENVEFGSI--------QLSLSEEQNEVMKNGCESKELVYLVQIACQGKSWIVKR 185

  Fly   179 P-----SLPKNQIPSVGNKR-SRL-----STGLNGSMSGTTP--TTGKSRRSSVGIGVEQHTVDV 230
            .     .|.|:....:.::| |:|     |..|..|....|.  |...||.|::.
Mouse   186 SYEDFRVLDKHLHLCIYDRRFSQLTELPRSDVLKDSPESVTQMLTAYLSRLSTIA---------- 240

  Fly   231 GQGAERFCATTKVTIPQDGQG---VIRAESTIESLPVIAGNERIGDGLSSTPRRSVLKEATA--- 289
              |.:..|......:..|.:|   ::..||:|.:..|.|.:              |:|..||
Mouse   241 --GNKINCGPALTWMEIDNKGNHLLVHEESSINTPAVGAAH--------------VIKRYTARAP 289

  Fly   290 ----------------PP----------------LTP------VNAMAPHVVAESGTPLQHRPLM 316
                            ||                |.|      :|...|..|..| .|   :|:.
Mouse   290 DELTLEVGDIVSVIDMPPKVLSTWWRGKHGFQVGLFPGHCVELINQKVPQSVTNS-VP---KPVS 350

  Fly   317 RNH----TFSQKTFLRGDNCVQCQKRIRFGAVGLRCRDCPVRCHIDCRYLLTVSCVPQTGTPTTK 377
            :.|    || .:||::.....  ||..:.|.:..|...|.:..|:
Mouse   351 KKHGKLITF-LRTFMKSRPTK--QKLKQRGILKERVFGCDLGEHL-------------------- 392

  Fly   378 TMTGYVTDFAPSIAPMIPALIVHCVNEIEARGLTEVGLYRLSSSEREYKALKEQFLRGKATPHLG 442
            ..:|:          .:|.::..|...||..|:.: |:||||......:.|:.:| ..:..|.|.
Mouse   393 LNSGF----------EVPQVLQSCTAFIERYGIVD-GIYRLSGVASNIQRLRHEF-DSEHVPDLT 445

  Fly   443 N----TDIYVLCCCVKDFLRSLTEPLIPTSQWKDFANAVQNPDTKTAQDMLVK---SVKQLPQAN 500
            .    .||:.:....|.:.|.|..||:....::.|::||   ...|.::.|:|   .::|||..:
Mouse   446 KEPYVQDIHSVGSLCKLYFRELPNPLLTYQLYEKFSDAV---SAATDEERLIKIHDVIQQLPPPH 507

  Fly   501 RDTLAFLILHFQRIAQ-CPVVLMPIDNISLIFGPTIVGYSTPDPDQHAIYTEVFTQKQVMKALLE 564
            ..||.||:.|...:|. |.:..|...|:::::.|.::                 ..||:..|...
Mouse   508 YRTLEFLMRHLSLLADYCSITNMHAKNLAIVWAPNLL-----------------RSKQIESACFS 555

  Fly   565 LPVSFWE---QYIVID 577
            ...:|.|   |.:|::
Mouse   556 GTAAFMEVRIQSVVVE 571

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tum	NP_610912.2	C1	319..367	CDD:237996	11/51 (22%)
tum	NP_610912.2	RhoGAP_MgcRacGAP	381..570	CDD:239847	44/196 (22%)
Arhgap32	XP_006510505.1	PX_RICS	141..255	CDD:132831	23/133 (17%)
		SH3_ARHGAP32_33	277..330	CDD:212769	9/66 (14%)
		RhoGAP_CdGAP	382..576	CDD:239849	51/242 (21%)
		PHA03247	<1251..1633	CDD:223021
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3564
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900