Protein Alignment tum and Racgap1

DIOPT Version :10

• Sequence 1: NP_610912.2
• Gene: tum / 36538
• FlyBaseID: FBgn0086356
• Length: 625
• Species: Drosophila melanogaster
• Sequence 2: NP_001101582.1
• Gene: Racgap1 / 315298
• RGDID: 1305912
• Length: 626
• Species: Rattus norvegicus
• Alignment Length: 653
• Identity: 220/653 - (33%)
• Similarity: 331/653 - (50%)
• Gaps: 84/653 - (12%)

  Fly     9 FDDLRRCMQVLTDGTPEEEFLRFLRMFEQYHEKCAGYAAETARIQNELDKSLTKMGDLEGKLFHA 73
            |:.|.|.::::.:|....||::.::.||.:.:||.....|..:.::.|.|:.|....|:.||.||
  Rat    12 FEQLVRRLEIINEGNESIEFIQVVKDFEDFRKKCQRTNQELEKFKDLLLKAETGRSALDVKLKHA 76

  Fly    74 RRIIDMEIKARRQAEHERDAMESKIMAVADLLRHER----NLNNETRDKLAFLHTLPSSRKRKSL 134
            |..:|:|||.|::||.|...:|.:|..:.|:|..:.    .|:.|.:..||||:...:|......
  Rat    77 RNQVDVEIKRRQRAEAECAKLEQQIQLIRDILMCDTTGSIQLSEEQKSALAFLNRGQASSGNAGN 141

  Fly   135 NAVREDKSYGDINSTGSLLSDLSITHSEDDFLDVRTSKSWREHRPSLPKNQIPSVGNKRSRLSTG 199
            |.:      ..|:.:||:|||:|...: |:.||      |..   ||...::.....:||.....
  Rat   142 NRL------STIDESGSILSDISFDKT-DESLD------WDS---SLKNFKMKKREKRRSSSRQF 190

  Fly   200 LNGSMSGTTPTTGKSRRSSVGIGVEQHTVDVGQGAERFCATTKVTIPQDGQGVIRAESTIESLPV 264
            ::|      |.....:..|:|     .|:|  |..|...|.|.||:|.|| |.|.|.||||:||.
  Rat   191 IDG------PPGPVKKTCSIG-----STID--QANESIVAKTTVTVPSDG-GPIEAVSTIETLPC 241

  Fly   265 IAGNERIGDGLSSTPRRSVLKEATAPPLTPVNAMAPHVVAESGTPLQHRPLMRNHTFSQKTFLRG 329
            ...:......|......|.|......|.|..:|:        |||..:.  ||.|.|..||.::.
  Rat   242 WTRSRGKSGPLQPVNSDSALNSRPLEPRTETDAV--------GTPQNNG--MRLHDFVSKTVIKP 296

  Fly   330 DNCVQCQKRIRFGAVGLRCRDCPVRCHIDCRYLLTVSCVPQ-TGTPTTKTMTGYVTDFAPSIAPM 393
            ::||.|.|||:||.:.|:||||.:..|.:||....:.|:|. .||| .|...|.:.||....:||
  Rat   297 ESCVPCGKRIKFGKLSLKCRDCRLVSHPECRDRCPLPCIPPLVGTP-VKIGEGMLADFVSQTSPM 360

  Fly   394 IPALIVHCVNEIEARGLTEVGLYRLSSSEREYKALKEQFLRGKATPHLGNT-DIYVLCCCVKDFL 457
            |||::|.||||||.|||||.||||:|..:|..|.|||:||:.|..|.|... ||:.:|..:||||
  Rat   361 IPAIVVSCVNEIEQRGLTEAGLYRISGCDRTVKELKEKFLKVKTVPLLSKVDDIHAICSLLKDFL 425

  Fly   458 RSLTEPLIPTSQWKDFANAVQNPDTKTAQDMLVKSVKQLPQANRDTLAFLILHFQRIAQCPVVLM 522
            |:|.|||:.....|.|..|.:..|...:...:.::|.:||||||||||||::|.||:||.|...|
  Rat   426 RNLKEPLLTFWLSKAFMEAAEITDEDNSTAAMYQAVSELPQANRDTLAFLMIHLQRVAQSPSTKM 490

  Fly   523 PIDNISLIFGPTIVGYSTPDPDQHAIYTEVFTQKQVMKALLELPVSFWEQYIVID---------- 577
            .:.|::.|||||||.::.|:||...::.::..|.:|::.||.||:.:|.|:::::
  Rat   491 DVVNLAKIFGPTIVAHTVPNPDPVTMFQDIKRQLKVVERLLSLPLEYWNQFMMVEQENMDCHRGN 555

  Fly   578 ----------------PTRTPATVIKRVPSNKNDLLSLY----ATPFKGGTIK-------KRKFY 615
                            |..||...:.:.||:.:....||    :||..|...|       :.||:
  Rat   556 GSSTPRTPDIKVSLLGPVTTPEFQLVKTPSSNSLSQRLYNLSKSTPRFGNKSKSATNLGQQGKFF 620

  Fly   616 GTP 618
            ..|
  Rat   621 PAP 623

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tum	NP_610912.2	C1_MgcRacGAP	317..369	CDD:410371	22/51 (43%)
		RhoGAP_MgcRacGAP	381..570	CDD:239847	88/189 (47%)
Racgap1	NP_001101582.1	Tropomyosin	43..>108	CDD:459736	23/64 (36%)
		C1_MgcRacGAP	284..337	CDD:410371	22/52 (42%)
		RhoGAP_MgcRacGAP	345..538	CDD:239847	88/192 (46%)