Protein Alignment tum and Arhgap21

DIOPT Version :9

• Sequence 1: NP_610912.2
• Gene: tum / 36538
• FlyBaseID: FBgn0086356
• Length: 625
• Species: Drosophila melanogaster
• Sequence 2: NP_001178622.1
• Gene: Arhgap21 / 307178
• RGDID: 1311028
• Length: 1952
• Species: Rattus norvegicus
• Alignment Length: 619
• Identity: 135/619 - (21%)
• Similarity: 223/619 - (36%)
• Gaps: 172/619 - (27%)

  Fly    84 RRQAEHERDAMESKIMAVADLLRHERN------LNNETRD-KLAFLHTLPSSRKRKSLNAVREDK 141
            |||..|:::::....:......:.||:      |::...| ||:|.|.       .||..::...
  Rat   856 RRQLSHDQESVGPPSLDGQHTSKTERSKSYDEGLDDYREDAKLSFKHV-------SSLKGIKIAD 913

  Fly   142 SYGDINSTGSLLSDLSITHSEDDFLDVRTSKSWREHRPSLPKNQIPSVGNKRSRLSTGLNGS--- 203
            |......:||....     |.:.|.|. ..:.|.:.|        |.|.:|..|    :.||
  Rat   914 SQKSSEDSGSRKDS-----SSEVFSDA-AKEGWLQFR--------PLVTDKGKR----VGGSIRP 960

  Fly   204 -------MSGTTPTTGKSRRSSV-------GIGVEQHTVDVGQGAER----FCATTKVTIPQDGQ 250
                   :.|.:....|.||...       .|.|....:|:.....:    |..||     .|.:
  Rat   961 WKQMYVVLRGHSLYLYKDRREQTTPSEEEQPISVNACLIDISYSETKRRNVFRLTT-----SDCE 1020

  Fly   251 GVIRAESTIESLPVI--------AGNERIG---------------------DGLSSTPRRSV--- 283
            .:.:||...:.|..|        ...|..|                     :.|..|||:|:
  Rat  1021 CLFQAEDRDDMLAWIKTIQESSNLNEEDTGVTNRDLISRRIKEYNSLLSKTEQLPKTPRQSLSIR 1085

  Fly   284 --LKEATAPPLTPVNAMAPHVVAESGTPLQHRPLMRNHTFSQK---TFLRGDNCVQC----QKRI 339
              |..|.:.|.|    .:||...|..   :.:.|.::.|...|   |:.||...:..    :|..
  Rat  1086 QTLLGAKSEPKT----QSPHSPKEES---ERKLLSKDDTSPPKDKGTWRRGIPSIVRKTFEKKPA 1143

  Fly   340 RFGAVGLRCRDCPVRCHIDCRYLLTVSCVPQTGTPTTKTMTGYVTDFAPSIAPMIPALIVHCVNE 404
            ..|..|:|..||| ..|.: ||                                ||.::..|...
  Rat  1144 ATGTFGVRLDDCP-PAHTN-RY--------------------------------IPLIVDICCKL 1174

  Fly   405 IEARGLTEVGLYRLSSSEREYKALKEQFLRGKATPHLGN---TDIYVLCCCVKDFLRSLTEPLIP 466
            :|.|||...|:||:..:.....:::|:..:|.|...:.:   .|:.|:...:|.|.|.|.|||..
  Rat  1175 VEERGLEYTGIYRVPGNNAAISSMQEELNKGMADIDIQDDKWRDLNVISSLLKSFFRKLPEPLFT 1239

  Fly   467 TSQWKDFANAVQNPDTKTAQDMLVKSVKQLPQANRDTLAFLILHFQRIAQ-CPVVLMPIDNISLI 530
            ..::.||..|.:..|.......|.:.:..||:.:.:||.||..|.:.:|: .....|...|::::
  Rat  1240 NDKYADFIEANRKEDPLDRLRTLKRLIHDLPEHHFETLKFLSAHLKTVAENSEKNKMEPRNLAIV 1304

  Fly   531 FGPTIVGYS--------TPDPDQHAIYTEV-------FTQKQVMKALLELPVSFWEQYIVIDPTR 580
            ||||:|..|        |..|||:.|...:       ||::..     |.|::..::...:|...
  Rat  1305 FGPTLVRTSEDNMTHMVTHMPDQYKIVETLIQHHDWFFTEEGA-----EEPLTAVQEENTVDSQP 1364

  Fly   581 TP-----ATVIKR---VPSNKNDLLSLYATPFKG 606
            .|     .|.|.|   :|.:.:|..:..:|..||
  Rat  1365 VPNIDHLLTNIGRTGVLPGDVSDSATSDSTKSKG 1398

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tum	NP_610912.2	C1	319..367	CDD:237996	15/54 (28%)
		RhoGAP_MgcRacGAP	381..570	CDD:239847	52/207 (25%)
Arhgap21	NP_001178622.1	PDZ_signaling	52..159	CDD:238492
		PH_ARHGAP21-like	936..1045	CDD:269955	23/125 (18%)
		PH	937..1042	CDD:278594	23/121 (19%)
		RhoGAP_ARHGAP21	1147..1342	CDD:239860	56/228 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910