DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tum and Arhgap27

DIOPT Version :9

Sequence 1:	NP_610912.2	Gene:	tum / 36538	FlyBaseID:	FBgn0086356	Length:	625	Species:	Drosophila melanogaster
Sequence 2:	NP_942054.1	Gene:	Arhgap27 / 303583	RGDID:	735202	Length:	869	Species:	Rattus norvegicus

Alignment Length:	630	Identity:	134/630 - (21%)
Similarity:	223/630 - (35%)	Gaps:	219/630 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 SALASFDDLRRCMQVLTDG------TPEEEFLRFLRMFEQYHEKCAGYAAETARIQNELDKSLTK 62
            |.:.||.||.....::...      |||::.| :...|.|                    :...:
  Rat   379 SPVGSFSDLGPTSPLVAPPGWSCQITPEKQML-YTNQFTQ--------------------EQWVR 422

  Fly    63 MGDLEGKLFHAR---RIIDMEI--------KARRQAEHERDA------MESKIMAVADLLRHERN 110
            :.|.|||.:...   ..:..|:        ::.|::..:.|.      .|.||
  Rat   423 LEDQEGKPYFYNPEDSSVQWELPQVPVPAPRSGRKSSQDSDTPAQASPPEEKI------------ 475

  Fly   111 LNNETRDKLAFLHTLPSSRKRKSLNAVREDKSYGDINSTGSLLSDLSITHSEDDFLDVRTSKSWR 175
               :|.||...||...:..|.|.|.     |.:.  |::.::|....:|.    |.|.:||.:..
  Rat   476 ---KTLDKAGVLHRTKTVDKGKRLR-----KKHW--NASWTVLEGGVLTF----FKDSKTSAASG 526

  Fly   176 EHRPSLPKNQIPSVGNKRSRLST-----GLNGSMSGTTPTTGKSRRSSVGI----GVE---QHTV 228
            ..:|              |:|||     .|.|:.....|....|:::.:.:    |.|   ||..
  Rat   527 LRQP--------------SKLSTPEYTVELRGASLSWAPKDKSSKKNVLELRSRDGSEYLIQHDS 577

  Fly   229 D---------VGQGAERFCATTKVTIPQDGQGVIRAESTIESLPVIAGNERIGDGLSSTPRRSVL 284
            :         :.:|.|...|    .:||..:|.       .|......:||:|    |.....|.
  Rat   578 EAIISTWHKAIAEGIEELSA----DLPQREEGE-------PSSADFGSSERLG----SWKEEDVR 627

  Fly   285 KEATAPPLTPVNAMAPHVVAESGTPLQHRPLMR-NHTFSQKTFLRGDNCVQCQKRIRFGAVGLRC 348
            ..|.:|.|.|.:              |...|.| .|..  :.||        |:|
  Rat   628 PNAASPSLNPGS--------------QESDLSRVRHKL--RKFL--------QRR---------- 658

  Fly   349 RDCPVRCHIDCRYLLTVSCVPQTGTPTTKTM--TGYVTD--FAPSIAPM-------IPALIVHCV 402
                                     ||.:::  .||:.|  |..::|.:       :|..:..|:
  Rat   659 -------------------------PTLQSLREKGYIKDQVFGCALAQLCERERSPVPRFVQQCI 698

  Fly   403 NEIEARGLTEVGLYRLSSS-----EREYKALKEQFLRGKATPHLGN---TDIYVLCCCVKDFLRS 459
            ..:|||||...||||:|.:     :..||...::.|      .|.:   .|::|:...:|.|.|.
  Rat   699 RTVEARGLDIDGLYRISGNLATIQKLRYKVDHDERL------DLDDGRWEDVHVITGALKLFFRE 757

  Fly   460 LTEPLIPTSQWKDFANAVQNPDTKTAQDMLVKSVKQLPQANRDTLAFLILHFQRIAQCPVV---- 520
            |.|||.|.|.:..|..|::..|.......:...|:.||..|.|||..||.|.     |.|:
  Rat   758 LPEPLFPFSHFHQFIAAIKLQDPAQRSRCVRDLVRTLPAPNHDTLRLLIQHL-----CRVIEHGE 817

  Fly   521 --LMPIDNISLIFGPTIVGYSTPDPDQHAIYTEVFTQKQVMKALL 563
              .|.:.|::::||||::   .|:.::.::...:..|.||::.:|
  Rat   818 QNRMSVQNVAIVFGPTLL---RPEMEEASMPMTMVFQNQVVELIL 859

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tum	NP_610912.2	C1	319..367	CDD:237996	5/47 (11%)
tum	NP_610912.2	RhoGAP_MgcRacGAP	381..570	CDD:239847	58/206 (28%)
Arhgap27	NP_942054.1	SH3	10..66	CDD:302595
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	104..137
		WW	248..278	CDD:278809
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	275..299
		WW	301..328	CDD:278809
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	331..389		5/9 (56%)
		WW	418..445	CDD:278809	5/26 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	447..474		3/26 (12%)
		PH_ARHGAP9-like	480..594	CDD:270053	28/138 (20%)
		PH	480..593	CDD:278594	28/137 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	598..644		14/70 (20%)
		RhoGAP_ARHGAP27_15_12_9	675..861	CDD:239868	55/199 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910