DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tum and Arhgap23

DIOPT Version :9

Sequence 1:	NP_610912.2	Gene:	tum / 36538	FlyBaseID:	FBgn0086356	Length:	625	Species:	Drosophila melanogaster
Sequence 2:	XP_006247499.1	Gene:	Arhgap23 / 303501	RGDID:	1309742	Length:	1383	Species:	Rattus norvegicus

Alignment Length:	563	Identity:	125/563 - (22%)
Similarity:	201/563 - (35%)	Gaps:	176/563 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    81 IKARRQAEHERDAMESKIMAVADLLRHERNLN-----NETRDKLAFLHTLPSSRKRKSLNAVRED 140
            |||.|::        |.::|:..    ||:.:     |..||:...|..||:  :..||..:|..
  Rat   508 IKAGRRS--------SYLLAITT----ERSKSCDDGLNTFRDEGRVLRRLPN--RVPSLRMLRSF 558

  Fly   141 KSYGDINSTGS-----------LLSDLSITHSEDDFLDVRTSKSWREHRPSLPKNQIPSVGNKRS 194
            .:.|.::|.|:           ..|||    |:..|.|:| .:.|..::..|.|.     |.|
  Rat   559 FTDGSLDSWGTSEDAEAPSKRHSTSDL----SDATFSDIR-REGWLYYKQILTKK-----GKK-- 611

  Fly   195 RLSTGLNGSMSGTTPTTGKSRRSSVGIGVEQHTVDVGQGAERFCATTKVTIPQDGQGVIRAESTI 259
                 ..|.:..........|..|:.:..|:.  :.|..|....|.        |.|      ..
  Rat   612 -----AGGGLRQWKRVYAVLRARSLSLSKERR--EPGPAAAGAAAA--------GAG------ED 655

  Fly   260 ESLPVIAGNERIGDGLSSTPRRSVLKEATA-------------PPLTPVNAMAPHVVAESGTP-L 310
            |:.||..|:..:....|.|.||.|.:..||             ..|..:.|:..:..||...| .
  Rat   656 EAAPVCIGSCLVDISYSETKRRHVFRLTTADFCEYLFQAEDRDDMLGWIRAIRENSRAEGEDPGC 720

  Fly   311 QHRPLMR---------NHT---------------------FSQKTFLR----------------- 328
            .::.|:.         :|:                     |.::|.:|
  Rat   721 ANQALISKKLNDYRKVSHSSGPKADSSPKGSRGLGGLKSEFLKQTAVRGLRTQDQPAGSKEDSVT 785

  Fly   329 ------GDNCVQCQKRIRFGAVGLRCRDCPVRCHIDCRYLLTVSCVPQTGTPTTKTMTGYVTDFA 387
                  |.|.::..|:....|.|:|..||                     .|.|:..
  Rat   786 TPKTPWGINIIKKNKKAAPRAFGIRLEDC---------------------QPATENQ-------- 821

  Fly   388 PSIAPMIPALIVHCVNEIEARGLTEVGLYRLSSSEREYKALKEQFLRGKATPHLGN---TDIYVL 449
                 .:|.::..|...:|||||...|:||:..:.....:|:||..||.:..:|.:   .|:.|:
  Rat   822 -----RVPLIVAACCRIVEARGLESTGIYRVPGNNAVVSSLQEQLNRGPSDINLQDERWQDLNVI 881

  Fly   450 CCCVKDFLRSLTEPLIPTSQWKDFANAVQNPDTKTAQDMLVKSVKQLPQANRDTLAFLILHFQRI 514
            ...:|.|.|.|.|||....::.||..|.:..|::.....|.|.::.||....:||.||:.|.:.|
  Rat   882 SSLLKAFFRKLPEPLFTDDKYNDFIEANRIEDSRERMKTLRKLIRDLPGHYYETLKFLVGHLKTI 946

  Fly   515 A-QCPVVLMPIDNISLIFGPTIVGYS--------TPDPDQHAI 548
            | ......|...|::|:||||:|..|        |..||::.|
  Rat   947 ADHSEKNKMEPRNLALVFGPTLVRTSEDNMTDMVTHMPDRYKI 989

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tum	NP_610912.2	C1	319..367	CDD:237996	12/91 (13%)
tum	NP_610912.2	RhoGAP_MgcRacGAP	381..570	CDD:239847	53/180 (29%)
Arhgap23	XP_006247499.1	PDZ_signaling	<4..57	CDD:238492
		PH	593..712	CDD:278594	28/147 (19%)
		PH_ARHGAP21-like	594..714	CDD:269955	28/148 (19%)
		RhoGAP_ARHGAP21	806..1001	CDD:239860	60/218 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910