DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment tum and Arhgap28

DIOPT Version :9

Sequence 1:NP_610912.2 Gene:tum / 36538 FlyBaseID:FBgn0086356 Length:625 Species:Drosophila melanogaster
Sequence 2:NP_001178744.1 Gene:Arhgap28 / 301709 RGDID:1559882 Length:726 Species:Rattus norvegicus


Alignment Length:592 Identity:118/592 - (19%)
Similarity:208/592 - (35%) Gaps:172/592 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly    80 EIKARRQAEHERDAMESKIMAVADLLRHERNLNNETRDKLAFLHTLPSSR--------------- 129
            |:|...:.|.|.:.::.  :.::.|:.     .:|..|..|.|.||..::               
  Rat   105 EVKPVDEGELEAEWLQD--VGLSTLIS-----GDEEEDGKALLSTLTRTQAAAVKKRYNTYTQTL 162

  Fly   130 KRKSLNAVREDKS-YGDINSTGS----LLSDLSITHSEDDFLDV-RTSKSWREHRPSLPKNQIPS 188
            ::|:..|:|:.:. :|...|..|    ..:.|..|..|.|...| :||      || ||.     
  Rat   163 RKKNKQAIRDVRDVFGVSESPPSDSCEHATQLDSTKEEKDLPGVTKTS------RP-LPD----- 215

  Fly   189 VGNKRSRLSTGLNGSMSGTTPTTGKSRRSSVGIGVEQHTVDVGQGAERFCATTKVTIPQDGQGVI 253
                        :.|::.||.:.|........:.::..:|.:.:...        .||....|..
  Rat   216 ------------DASLNSTTLSNGAQDEEGGFVALQSGSVSILEAIP--------DIPVHTNGSA 260

  Fly   254 RAESTIE-----------SLPVIAGNERI------GDGLSSTPRRSVLKEATAPPLTPVNAMAPH 301
            ..|.:::           ::|..|  |.:      .:.::.||.|:..|::   .:...:.:.|.
  Rat   261 DTEQSVQRGLSDDDYLEKNIPPEA--EELSFEVSYSEVVTETPDRNKWKKS---DIKKEDYVLPK 320

  Fly   302 VVAESGTPLQHRPLMRNHTFSQKTFL----RGDNCVQCQKRIR----------FGAVGL------ 346
            .:.                  |||..    .||...:..|:||          |.|..:      
  Rat   321 FIV------------------QKTRFGLTETGDLSAEDMKKIRHLSLIELTAFFDAFRIQLKRNK 367

  Fly   347 ----RCRDCPVRCHIDCRYLLTVSCVPQTGTPTTKTMTGYVTDFAPSIAPMIPALIVHCVNEIEA 407
                |.||..:                 .|.|.|..:.   .|.....|..:|.::.....::|.
  Rat   368 TERVRGRDNGI-----------------FGVPLTVLLD---NDRKKDPAVKVPLVLQKFFQKVEE 412

  Fly   408 RGLTEVGLYRLSSSEREYKALKEQFLRGKATPHLGNTDIY---VLC-----CCVKDFLRSLTEPL 464
            .||...|::|||....:.|..:|: |..:.     |||.:   .:|     ..:|.|.|.|...|
  Rat   413 SGLESEGIFRLSGCTAKVKQYREE-LDARF-----NTDKFKWDKMCHREAAVMLKAFFRELPTSL 471

  Fly   465 IPTSQWKDFANAVQ-NPDTKTAQDMLVKSVKQLPQANRDTLAFLILHFQR-IAQCPVVLMPIDNI 527
            .|......|.:.:: .||.|.....|...|..||.|||||...|:..|.: ||......|.:.||
  Rat   472 FPIEYIPAFISLMERGPDIKVQFQALHLMVMALPDANRDTAQALMTFFNKVIANESKNRMSLWNI 536

  Fly   528 SLIFGPTIVGYSTPDPDQHAIYTEVF---TQKQVMKALLELPVSFWE--QYIVIDPTR-TPATVI 586
            |.:..|.:. :|.   .:|:...|:.   |...:::.:|......|:  .:::....| ..||::
  Rat   537 STVMAPNLF-FSR---SKHSDCEELLVANTAAHIIRLMLTYQKILWKVPSFLITQVRRMNEATML 597

  Fly   587 --KRVPS 591
              |::||
  Rat   598 LKKQLPS 604

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
tumNP_610912.2 C1 319..367 CDD:237996 13/71 (18%)
RhoGAP_MgcRacGAP 381..570 CDD:239847 50/201 (25%)
Arhgap28NP_001178744.1 RhoGAP_ARHGAP18 378..589 CDD:239856 54/240 (23%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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