DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tum and Sh3bp1

DIOPT Version :9

Sequence 1:	NP_610912.2	Gene:	tum / 36538	FlyBaseID:	FBgn0086356	Length:	625	Species:	Drosophila melanogaster
Sequence 2:	NP_001165452.1	Gene:	Sh3bp1 / 300067	RGDID:	1306275	Length:	689	Species:	Rattus norvegicus

Alignment Length:	548	Identity:	109/548 - (19%)
Similarity:	189/548 - (34%)	Gaps:	149/548 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 RMFEQYHEKCAGYAAETARIQNELDKSLTKMGDLEGKLFHARRI---IDMEIKARRQAEHERDAM 94
            ||.:..|...:|...|||....|      .:..:|.:|..|:|.   :...::|..|.:...| |
  Rat     8 RMRQLAHTGSSGRTPETAEFLGE------DLLQVEQRLEPAKRAAHNVHKRLQACLQGQSGAD-M 65

  Fly    95 ESKI-----MAVADLLRHERNLNNETRDKLAFLHTLPSSRKRKSLNAVREDKSYGDINSTGSLLS 154
            :.::     ||::..:..            :|....|.|...|:|     :.|....|....:|:
  Rat    66 DKRVKKLPLMALSTAMAE------------SFKELDPDSSMGKAL-----EMSCAIQNQLARILA 113

  Fly   155 DLSITHSEDDFLDVRTSKSWREHRPSLPKNQIPSVGNKRSRLS------TGLNGSMSGTTPTTGK 213
            :..:|...|....:.          .|.:.::|::..::..|.      ..|...:|.....:|.
  Rat   114 EFEMTLERDVLQPLN----------RLSEEELPAILKRKKSLQKLVSDWNTLKSRLSQAAKNSGS 168

  Fly   214 SRRSSVGIGVEQHTVDVGQGAERFCATTKV-TIPQDGQGVIRAESTIESLPVIAGNERIGDGLS- 276
            |:  |:|.|...||        ......|| |:.:|.:.:.|.....:       :|.:.|...
  Rat   169 SQ--SLGGGSSSHT--------HMATANKVETLKEDEEELKRKVEQCK-------DEYLADLYHF 216

  Fly   277 STPRRSV------LKEATA----PPLTPVN-AMAP----HVVAESGTPLQHRPLMRNHTFSQKTF 326
            ||...|.      |.|..|    ..||.:: |:|.    |..|:|.......|..|.:..|.:|.
  Rat   217 STKEDSYANYFTHLLEIQADYHRKSLTSLDTALAELRDNHSQADSSPLTTAAPFSRVYGVSLRTH 281

  Fly   327 LRGDNCVQCQKRIRFGAVGLRCRDCPVRCHIDCRYLLTVSCVPQTGTPTTKTMTGYVTDFAPSIA 391
            |:                                                        |....||
  Rat   282 LQ--------------------------------------------------------DLGRDIA 290

  Fly   392 PMIPALIVHCVNEIEARGLTEVGLYRLSSSEREYKALKEQFLRGKATPHLGN---TDIYVLCCCV 453
            ..|.|    ||..:.:.|:.|.||:||::.....|.||:..   .:.||...   :|.:.:...:
  Rat   291 LPIEA----CVLLLLSEGMQEEGLFRLAAGASVLKRLKQTM---ASDPHSLEEFCSDPHAVAGAL 348

  Fly   454 KDFLRSLTEPLIPTSQWKDFANAVQNPDTKTAQDMLVKSVKQLPQANRDTLAFLILHFQRIA-QC 517
            |.:||.|.|||:.:..:.|:..|....:.....:.|.....:|||.|.:.|.:|:.....:| :.
  Rat   349 KSYLRELPEPLMTSDLYDDWMRAASLKEPGARLEALHDVCSRLPQENFNNLRYLMKFLALLAEEQ 413

  Fly   518 PVVLMPIDNISLIFGPTIVGYSTPDPDQ 545
            .|..|...||:::.||.::.....:.||
  Rat   414 DVNKMTPSNIAIVLGPNLLWPPEKEGDQ 441

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tum	NP_610912.2	C1	319..367	CDD:237996	3/47 (6%)
tum	NP_610912.2	RhoGAP_MgcRacGAP	381..570	CDD:239847	44/169 (26%)
Sh3bp1	NP_001165452.1	Interaction with CGNL1. /evidence=ECO:0000250\|UniProtKB:Q9Y3L3	1..275		62/317 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..24		4/15 (27%)
		BAR_SH3BP1	16..275	CDD:153304	59/309 (19%)
		RhoGAP	272..473	CDD:295372	48/233 (21%)
		Interaction with CD2AP. /evidence=ECO:0000250\|UniProtKB:Q9Y3L3	470..689
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	507..689
		SH3-binding. /evidence=ECO:0000250\|UniProtKB:P55194	611..620
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910