DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment tum and Arhgap18

DIOPT Version :9

Sequence 1:NP_610912.2 Gene:tum / 36538 FlyBaseID:FBgn0086356 Length:625 Species:Drosophila melanogaster
Sequence 2:NP_001164046.1 Gene:Arhgap18 / 293947 RGDID:1305053 Length:665 Species:Rattus norvegicus


Alignment Length:565 Identity:117/565 - (20%)
Similarity:189/565 - (33%) Gaps:162/565 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly     3 LSALASFDDLRRCMQVLTDGTPEEEFLRFLRMFEQYHEKCAGYAAETARIQNELDKSLTKMGDLE 67
            ||....||  |...|...|....|.:...|...::..|.|  ...:.|.:..|.|:     |:||
  Rat    54 LSERPPFD--RSSSQDSLDEVSMEAYWTELENIKRSTENC--QEGQEAIVVKEPDE-----GELE 109

  Fly    68 ---------GKLF------HARRIIDMEIKARRQAEHERDAMESKIMAVADLLRHERNLNNETRD 117
                     ..||      ....|:.:....|.||.    |::.::..|:..||           
  Rat   110 EEWLKEAGLSNLFGESADDSQESIVFLSTLTRTQAA----AVQKRVETVSQTLR----------- 159

  Fly   118 KLAFLHTLPSSRKRKSLNAVREDKSYGDINSTGSLLSDLSITHSEDDFLDVRTSKSWREHRPSLP 182
            |.:..:.:|..|...:.....::||..|     |.|..:....:||...|.:.|....:::..:|
  Rat   160 KKSKQYHIPDVRDIFAQQREAQEKSPDD-----SDLRSVRTNENEDQGKDDQPSSGAVDNKEPIP 219

  Fly   183 K--NQIPSVGNKRSRLSTGLNGSMSGTTPTTGKSRRSSVGIGVEQHTVDVGQGAERFCATTKVTI 245
            :  ..||:                            |...|.:|....:                
  Rat   220 RVPEDIPA----------------------------SETDINLEVSFAE---------------- 240

  Fly   246 PQDGQGVIRAESTIESLPVIAGNERIGDGLSSTPRRSVLKEATAPPLTPVNAMAPHVVAESGTPL 310
                |.|.:.|.:.|.:....||:      :|.|...:.|:.|.  .|.:..:||          
  Rat   241 ----QAVNQKELSKERMQKTRGND------ASLPSFRLPKDKTG--TTRIGDLAP---------- 283

  Fly   311 QHRPLMRNHTFSQKTFLRGDNCVQCQKRIRFGAVGLRCRDCPVRCHIDCRYLLTVSCVPQTGTPT 375
            |....:...:..:.|.|.....|:.:::   .||.::.||..:                 .|.|.
  Rat   284 QDMKKVCYLSLIELTALYDVLGVELKQQ---KAVKIKTRDSGL-----------------FGIPL 328

  Fly   376 TKTMTGYVTDFAPSIAPMIPALIVHCVNEIEARGLTEVGLYRLSSSEREYK----ALKEQFLRGK 436
            |..:.........:..|:|...::.|   ||...|...||.|:..:....|    .|:.:|..| 
  Rat   329 TILLEQDQRKVPGTRIPLIFQKLISC---IEEGSLETEGLLRIPGAAMRVKNLCQELEAKFYEG- 389

  Fly   437 ATPHLGNTDIYVLCCCVKDFLRSLTEPLIPTSQWKDFANAVQNPDTKTAQ-DMLVKSVKQLPQAN 500
             |.:..:...:.....:|.|||.|.:||:.|...|.| .||||..||..| ..|...|..||.||
  Rat   390 -TFNWESVKQHDAASLLKLFLRELPQPLLSTEYLKAF-QAVQNLPTKKEQLQALNLLVILLPDAN 452

  Fly   501 RDTLAFLILHFQRIAQCPVVLMPID----------NISLIFGPTI 535
            ||||..|:...||:         ||          |::::..|.:
  Rat   453 RDTLKALLEFLQRV---------IDNKEKNKMTAVNVAMVMAPNL 488

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
tumNP_610912.2 C1 319..367 CDD:237996 7/47 (15%)
RhoGAP_MgcRacGAP 381..570 CDD:239847 48/170 (28%)
Arhgap18NP_001164046.1 RhoGAP_ARHGAP18 323..536 CDD:239856 51/198 (26%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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