Protein Alignment tum and RACGAP1

DIOPT Version :9

• Sequence 1: NP_610912.2
• Gene: tum / 36538
• FlyBaseID: FBgn0086356
• Length: 625
• Species: Drosophila melanogaster
• Sequence 2: XP_024304726.1
• Gene: RACGAP1 / 29127
• HGNCID: 9804
• Length: 651
• Species: Homo sapiens
• Alignment Length: 649
• Identity: 228/649 - (35%)
• Similarity: 338/649 - (52%)
• Gaps: 86/649 - (13%)

  Fly     1 MALSALASFDDLRRCMQVLTDGTPEEEFLRFLRMFEQYHEKCAGYAAETARIQNELDKSLTKMGD 65
            |.|:....|:.|.|.:::|::|. |.:|::..:.||.:.:|......|..:.::.|.|:.|:...
Human    23 MMLNVRNLFEQLVRRVEILSEGN-EVQFIQLAKDFEDFRKKWQRTDHELGKYKDLLMKAETERSA 86

  Fly    66 LEGKLFHARRIIDMEIKARRQAEHERDAMESKIMAVADLLRHERN----LNNETRDKLAFLHT-L 125
            |:.||.|||..:|:|||.|::||.:.:.:|.:|..:.::|..:.:    |:.|.:..||||:. .
Human    87 LDVKLKHARNQVDVEIKRRQRAEADCEKLERQIQLIREMLMCDTSGSIQLSEEQKSALAFLNRGQ 151

  Fly   126 PSSRKRKSLNAVREDKSYGDINSTGSLLSDLSITHSEDDFLD-----VRTSK-SWREHRPSLPKN 184
            |||.     ||  .:|....|:.:||:|||:|...: |:.||     |:|.| ..||.|.|..:.
Human   152 PSSS-----NA--GNKRLSTIDESGSILSDISFDKT-DESLDWDSSLVKTFKLKKREKRRSTSRQ 208

  Fly   185 QIPSVGNKRSRLSTGLNGSMSGTTPTTGKSRRSSVGIGVEQHTVDVGQGAERFCATTKVTIPQDG 249
            .:                  .|......|:|  |:|..|:       ||.|...|.|.||:|.||
Human   209 FV------------------DGPPGPVKKTR--SIGSAVD-------QGNESIVAKTTVTVPNDG 246

  Fly   250 QGVIRAESTIESLPVIAGNERIGDGLSSTPRRSVLKEATAPPLTPVNAMAPHVVAESGTPLQHRP 314
             |.|.|.||||::|....:.|....|......|.|......|.|..:::        ||| |...
Human   247 -GPIEAVSTIETVPYWTRSRRKTGTLQPWNSDSTLNSRQLEPRTETDSV--------GTP-QSNG 301

  Fly   315 LMRNHTFSQKTFLRGDNCVQCQKRIRFGAVGLRCRDCPVRCHIDCRYLLTVSCVPQ-TGTPTTKT 378
            .||.|.|..||.::.::||.|.|||:||.:.|:||||.|..|.:||....:.|:|. .||| .|.
Human   302 GMRLHDFVSKTVIKPESCVPCGKRIKFGKLSLKCRDCRVVSHPECRDRCPLPCIPTLIGTP-VKI 365

  Fly   379 MTGYVTDFAPSIAPMIPALIVHCVNEIEARGLTEVGLYRLSSSEREYKALKEQFLRGKATPHLGN 443
            ..|.:.||....:||||:::||||||||.|||||.||||:|..:|..|.|||:|||.|..|.|..
Human   366 GEGMLADFVSQTSPMIPSIVVHCVNEIEQRGLTETGLYRISGCDRTVKELKEKFLRVKTVPLLSK 430

  Fly   444 T-DIYVLCCCVKDFLRSLTEPLIPTSQWKDFANAVQNPDTKTAQDMLVKSVKQLPQANRDTLAFL 507
            . ||:.:|..:|||||:|.|||:.....:.|..|.:..|...:...:.::|.:||||||||||||
Human   431 VDDIHAICSLLKDFLRNLKEPLLTFRLNRAFMEAAEITDEDNSIAAMYQAVGELPQANRDTLAFL 495

  Fly   508 ILHFQRIAQCPVVLMPIDNISLIFGPTIVGYSTPDPDQHAIYTEVFTQKQVMKALLELPVSFWEQ 572
            ::|.||:||.|...|.:.|::.:||||||.::.|:||...:..::..|.:|::.||.||:.:|.|
Human   496 MIHLQRVAQSPHTKMDVANLAKVFGPTIVAHAVPNPDPVTMLQDIKRQPKVVERLLSLPLEYWSQ 560

  Fly   573 YIV-----IDPTR---------TPATVIKRVPSNKNDLLSLYATPFKGGTIKKRKFYGTPPASA 622
            :::     |||..         ||.|     |..|..||....||       :.:...||.:|:
Human   561 FMMVEQENIDPLHVIENSNAFSTPQT-----PDIKVSLLGPVTTP-------EHQLLKTPSSSS 612

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tum	NP_610912.2	C1	319..367	CDD:237996	21/47 (45%)
		RhoGAP_MgcRacGAP	381..570	CDD:239847	87/189 (46%)
RACGAP1	XP_024304726.1	SMC_N	32..>124	CDD:330553	28/92 (30%)
		C1	306..354	CDD:237996	21/47 (45%)
		RhoGAP_MgcRacGAP	365..558	CDD:239847	87/192 (45%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	143	1.000	Domainoid score	I4660
eggNOG	1	0.900	-	-		E1_KOG3564
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H8077
Inparanoid	1	1.050	316	1.000	Inparanoid score	I2552
Isobase	1	0.950	-	0.928771	Normalized mean entropy	S4674
OMA	1	1.010	-	-		QHG49807
OrthoDB	1	1.010	-	-		D184774at33208
OrthoFinder	1	1.000	-	-		FOG0004815
OrthoInspector	1	1.000	-	-		oto89857
orthoMCL	1	0.900	-	-		OOG6_106233
Panther	1	1.100	-	-	LDO	PTHR46199
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4412
SonicParanoid	1	1.000	-	-		X3396
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.820