| Sequence 1: | NP_610912.2 | Gene: | tum / 36538 | FlyBaseID: | FBgn0086356 | Length: | 625 | Species: | Drosophila melanogaster |
|---|---|---|---|---|---|---|---|---|---|
| Sequence 2: | NP_004482.4 | Gene: | ARHGAP35 / 2909 | HGNCID: | 4591 | Length: | 1499 | Species: | Homo sapiens |
| Alignment Length: | 614 | Identity: | 132/614 - (21%) |
|---|---|---|---|
| Similarity: | 229/614 - (37%) | Gaps: | 147/614 - (23%) |
- Green bases have known domain annotations that are detailed below.
|
Fly 76 IIDMEIKARRQAEHERDAME--SKIMAVADLLRHERNLNNETRDKLAFLHTLPSS--RKRKSLNA 136
Fly 137 VREDKSYGDINST----------GSLLSDLSITHSEDDFLDVRTSKS-WREHRPSLPKNQIPSVG 190
Fly 191 NKRSRLSTGLNGS-------------MSGTTPTTGKSR---RSSVGIGVEQHTVDVG-QGAERFC 238
Fly 239 ATTKVTIPQDG----------QGVIR---AESTIESLPVIAGNERI--------------GDG-- 274
Fly 275 ----LSSTPRRSVLKEATAPPL-----TPVNAMAPHVVAES-GTPLQHRPLMRNHTFSQKTFLRG 329
Fly 330 DNCVQCQKRIRFGAVGLRCRDCPVRCHIDCRYLL--TVSCVPQTGTPTTKT----------MTGY 382
Fly 383 VTDFAPSIAPMIPALIVHCVNEIEARGLTEVGLYRLSSSEREYKALKEQFLRGKATPH---LGNT 444
Fly 445 DIYV--LCCCVKDFLRSLTEPLIPTSQWKDFANAVQNPDTKTAQDMLVKSVKQLPQANRDTLAFL 507
Fly 508 ILHFQRIA-QCPVVLMPIDNISLIFGPTIV--GYSTPDPDQHAIYTEVFTQKQVMKALLEL---- 565
Fly 566 -PVSFWEQYIVIDP---TRTPATVIKRVP 590 |
| Gene | Sequence | Domain | Region | External ID | Identity |
|---|---|---|---|---|---|
| tum | NP_610912.2 | C1 | 319..367 | CDD:237996 | 10/49 (20%) |
| RhoGAP_MgcRacGAP | 381..570 | CDD:239847 | 54/201 (27%) | ||
| ARHGAP35 | NP_004482.4 | Has GTPase activity, required for proper localization. /evidence=ECO:0000250|UniProtKB:Q91YM2 | 1..266 | ||
| RAS | <158..250 | CDD:214541 | |||
| RhoGAP-FF1 | 261..340 | CDD:406821 | |||
| FF | 371..422 | CDD:128718 | |||
| FF | 431..483 | CDD:128718 | |||
| FF | 486..539 | CDD:128718 | |||
| pseudoGTPaseD_p190RhoGAP-A | 594..765 | CDD:412066 | |||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 1058..1089 | 7/30 (23%) | |||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 1124..1146 | 4/21 (19%) | |||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 1177..1207 | 6/39 (15%) | |||
| Required for phospholipid binding and regulation of the substrate preference. /evidence=ECO:0000269|PubMed:19673492 | 1213..1236 | 7/23 (30%) | |||
| RhoGAP_p190 | 1247..1431 | CDD:239838 | 54/201 (27%) | ||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 1446..1499 | 4/15 (27%) | |||
| Blue background indicates that the domain is not in the aligned region. | |||||
| Tool | Simple Score | Weighted Score | Original Tool Information | |||
|---|---|---|---|---|---|---|
| BLAST Result | Score | Score Type | Cluster ID | |||
| Compara | 0 | 0.000 | Not matched by this tool. | |||
| Domainoid | 0 | 0.000 | Not matched by this tool. | |||
| eggNOG | 0 | 0.000 | Not matched by this tool. | |||
| Hieranoid | 0 | 0.000 | Not matched by this tool. | |||
| Homologene | 0 | 0.000 | Not matched by this tool. | |||
| Inparanoid | 0 | 0.000 | Not matched by this tool. | |||
| Isobase | 0 | 0.000 | Not matched by this tool. | |||
| OMA | 0 | 0.000 | Not matched by this tool. | |||
| OrthoDB | 0 | 0.000 | Not matched by this tool. | |||
| OrthoFinder | 0 | 0.000 | Not matched by this tool. | |||
| OrthoInspector | 0 | 0.000 | Not matched by this tool. | |||
| orthoMCL | 0 | 0.000 | Not matched by this tool. | |||
| Panther | 0 | 0.000 | Not matched by this tool. | |||
| Phylome | 1 | 0.910 | - | - | ||
| RoundUp | 0 | 0.000 | Not matched by this tool. | |||
| SonicParanoid | 0 | 0.000 | Not matched by this tool. | |||
| SwiftOrtho | 1 | 1.000 | - | - | ||
| TreeFam | 0 | 0.000 | Not matched by this tool. | |||
| User_Submission | 0 | 0.000 | Not matched by this tool. | |||
| 2 | 1.910 | |||||