DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tum and ABR

DIOPT Version :9

Sequence 1:	NP_610912.2	Gene:	tum / 36538	FlyBaseID:	FBgn0086356	Length:	625	Species:	Drosophila melanogaster
Sequence 2:	XP_016880028.1	Gene:	ABR / 29	HGNCID:	81	Length:	1137	Species:	Homo sapiens

Alignment Length:	571	Identity:	118/571 - (20%)
Similarity:	199/571 - (34%)	Gaps:	165/571 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    88 EHERDAMESKIMAVADLLRHERNLNNETR--DKLAFLHTLPSSRKRKS--------LNAV----- 137
            :||.:.|:.||.|:...::.|:....::|  ::|          |:|.        ||:.
Human   633 DHELEDMKMKISALKSEIQKEKANKGQSRAIERL----------KKKMFENEFLLLLNSPTIPFR 687

  Fly   138 ---REDKSYGDINSTGSLLSDLSITHSEDDFLDVRTSKSWREHRPSLPKNQIPSVGNKRSRLSTG 199
               |..|||         |..||..:...:         |||....|.|..:.:.......|..
Human   688 IHNRNGKSY---------LFLLSSDYERSE---------WREAIQKLQKKDLQAFVLSSVELQV- 733

  Fly   200 LNGS------MSGTTPTTGKSRRSSVGIGVEQHTV-----DVGQGAERFC-------------AT 240
            |.||      :.....|:.|....|.|:....|.:     ...|.|..:|             |.
Human   734 LTGSCFKLRTVHNIPVTSNKDDDESPGLYGFLHVIVHSAKGFKQSANLYCTLEVDSFGYFVSKAK 798

  Fly   241 TKV-------------TIPQDGQGVIRA---ESTIESLPVIAGNERIGDGLSSTPRRSVLKEATA 289
            |:|             .|..:|...:|.   |...:...|...|..|.|.:....:..:     .
Human   799 TRVFRDTAEPKWDEEFEIELEGSQSLRILCYEKCYDKTKVNKDNNEIVDKIMGKGQIQL-----D 858

  Fly   290 PPLTPVNAMAPHVVAESGTPLQHRPLMRNHTFSQKTFLRGDNCVQCQKRIRFGAVGLRCRDCPVR 354
            |...........|:..:|..::         ||.|...|..:..:...:.:.|..|::
Human   859 PQTVETKNWHTDVIEMNGIKVE---------FSMKFTSRDMSLKRTPSKKQTGVFGVK------- 907

  Fly   355 CHIDCRYLLTVSCVPQTGTPTTKTMTGYVTDFAPSIAPMIPALIVHCVNEIEARGLTEVGLYRLS 419
                      :|.|  |....:|                :|.::..||.|:|.||:.|||:||:|
Human   908 ----------ISVV--TKRERSK----------------VPYIVRQCVEEVEKRGIEEVGIYRIS 944

  Fly   420 SSEREYKALKEQFLRGKATPH---------------------LGNTDIYVLCCCVKDFLRSLTEP 463
            ....:.:|||..|...|....                     |.:.||..:...:|.:.|.|.||
Human   945 GVATDIQALKAVFDASKQLQKLTRADSLAQDDPTYNKDILLMLSDMDINAIAGTLKLYFRELPEP 1009

  Fly   464 LIPTSQWKDFANAVQNPDTKTAQDMLVKSVKQLPQANRDTLAFLILHFQRIAQC-PVVLMPIDNI 527
            |:....:..|...:...|....::.::..::.||..|..|..||:.|.:|:|:. |:..|.:.|:
Human  1010 LLTDRLYPAFMEGIALSDPAAKENCMMHLLRSLPDPNLITFLFLLEHLKRVAEKEPINKMSLHNL 1074

  Fly   528 SLIFGPTIVGYSTPDPDQHA-----IYT-EVFTQKQVMKALLE-LPVSFWE 571
            :.:||||::..|..:...|.     |:: :|..|.||:...|: .|:||.|
Human  1075 ATVFGPTLLRPSEVESKAHLTSAADIWSHDVMAQVQVLLYYLQHPPISFAE 1125

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tum	NP_610912.2	C1	319..367	CDD:237996	6/47 (13%)
tum	NP_610912.2	RhoGAP_MgcRacGAP	381..570	CDD:239847	55/217 (25%)
ABR	XP_016880028.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910