Protein Alignment tum and Racgap1

DIOPT Version :9

• Sequence 1: NP_610912.2
• Gene: tum / 36538
• FlyBaseID: FBgn0086356
• Length: 625
• Species: Drosophila melanogaster
• Sequence 2: NP_001240737.1
• Gene: Racgap1 / 26934
• MGIID: 1349423
• Length: 628
• Species: Mus musculus
• Alignment Length: 616
• Identity: 223/616 - (36%)
• Similarity: 327/616 - (53%)
• Gaps: 70/616 - (11%)

  Fly     9 FDDLRRCMQVLTDGTPEEEFLRFLRMFEQYHEKCAGYAAETARIQNELDKSLTKMGDLEGKLFHA 73
            |:.|.|.|:::.:|....||::.::.||.:.:|......|..:.::.|.|:.|....|:.||.||
Mouse    12 FEQLVRRMEIINEGNESIEFIQVVKDFEDFRKKYQRTNQELEKFKDLLLKAETGRSALDVKLKHA 76

  Fly    74 RRIIDMEIKARRQAEHERDAMESKIMAVADLLRHERN----LNNETRDKLAFLHTLPSSRKRKSL 134
            |..:|:|||.|::||.|...:|.:|..:.|:|..:.:    |:.|.:..||||:...:|......
Mouse    77 RNQVDVEIKRRQRAEAECAKLEQQIQLIRDILMCDTSGSIQLSEEQKSALAFLNRGQASSGHAGN 141

  Fly   135 NAVREDKSYGDINSTGSLLSDLSITHSEDDFLDVRTSKSWREHRPSLPKN-QIPSVGNKRSRLST 198
            |.:      ..|:.:||:|||:|...: |:.||      |..   ||.|| ::.....:||....
Mouse   142 NRL------STIDESGSILSDISFDKT-DESLD------WDS---SLVKNFKMKKREKRRSNSRQ 190

  Fly   199 GLNGSMSGTTPTTGKSRRSSVGIGVEQHTVDVGQGAERFCATTKVTIPQDGQGVIRAESTIESLP 263
            .::|      |.....:..|:|     .|||  |..|...|.|.||:|.|| |.|.|.||||:||
Mouse   191 FIDG------PPGPVKKTCSIG-----STVD--QANESIVAKTTVTVPSDG-GPIEAVSTIETLP 241

  Fly   264 VIAGNERIGDGLSSTPRRSVLKEATAPPLTPVNA--------MAPHVVAES-GTPLQHRPLMRNH 319
                        |.|..|     ..:.||.|||:        :.|....:: ||| |:...||.|
Mouse   242 ------------SWTRSR-----GKSGPLQPVNSDSALNSRPLEPRTDTDNLGTP-QNTGGMRLH 288

  Fly   320 TFSQKTFLRGDNCVQCQKRIRFGAVGLRCRDCPVRCHIDCRYLLTVSCVPQ-TGTPTTKTMTGYV 383
            .|..||.::.::||.|.|||:||.:.|:||||.:..|.:||....:.|:|. .||| .|...|.:
Mouse   289 DFVSKTVIKPESCVPCGKRIKFGKLSLKCRDCRLVSHPECRDRCPLPCIPPLVGTP-VKIGEGML 352

  Fly   384 TDFAPSIAPMIPALIVHCVNEIEARGLTEVGLYRLSSSEREYKALKEQFLRGKATPHLGNT-DIY 447
            .||....:|||||::|.||||||.|||||.||||:|..:|..|.|||:||:.|..|.|... ||:
Mouse   353 ADFVSQASPMIPAIVVSCVNEIEQRGLTEAGLYRISGCDRTVKELKEKFLKVKTVPLLSKVDDIH 417

  Fly   448 VLCCCVKDFLRSLTEPLIPTSQWKDFANAVQNPDTKTAQDMLVKSVKQLPQANRDTLAFLILHFQ 512
            |:|..:|||||:|.|||:.....|.|..|.:..|...:...:.::|.:||||||||||||::|.|
Mouse   418 VICSLLKDFLRNLKEPLLTFWLSKAFMEAAEITDEDNSTAAMYQAVSELPQANRDTLAFLMIHLQ 482

  Fly   513 RIAQCPVVLMPIDNISLIFGPTIVGYSTPDPDQHAIYTEVFTQKQVMKALLELPVSFWEQYIV-- 575
            |::|.|...|.|.|::.:||||||.::.|:||...::.::..|.:|::.||.||:.:|.|:::
Mouse   483 RVSQSPDTKMDIANLAKVFGPTIVAHTVPNPDPVTMFQDIKRQLKVVERLLSLPLEYWNQFMMVD 547

  Fly   576 ---IDPTRTPATVIKRVPSNKNDLLSLYATP 603
               ||..|.......|.|..|..||....||
Mouse   548 QENIDSQRGNGNSTPRTPDVKVSLLGPVTTP 578

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tum	NP_610912.2	C1	319..367	CDD:237996	20/47 (43%)
		RhoGAP_MgcRacGAP	381..570	CDD:239847	88/189 (47%)
Racgap1	NP_001240737.1	Tropomyosin	43..>108	CDD:395200	22/64 (34%)
		Interaction with SLC26A8. /evidence=ECO:0000250	107..286		64/226 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	179..201		4/27 (15%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	242..284		13/47 (28%)
		C1_MgcRacGAP	286..339	CDD:410371	22/52 (42%)
		RhoGAP_MgcRacGAP	347..540	CDD:239847	88/192 (46%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	143	1.000	Domainoid score	I4632
eggNOG	1	0.900	-	-		E1_KOG3564
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H8077
Inparanoid	1	1.050	322	1.000	Inparanoid score	I2491
Isobase	1	0.950	-	0.928771	Normalized mean entropy	S4674
OMA	1	1.010	-	-		QHG49807
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004815
OrthoInspector	1	1.000	-	-		oto93431
orthoMCL	1	0.900	-	-		OOG6_106233
Panther	1	1.100	-	-	LDO	PTHR46199
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4412
SonicParanoid	1	1.000	-	-		X3396
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.810