DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tum and ARHGAP30

DIOPT Version :9

Sequence 1:	NP_610912.2	Gene:	tum / 36538	FlyBaseID:	FBgn0086356	Length:	625	Species:	Drosophila melanogaster
Sequence 2:	NP_001020769.1	Gene:	ARHGAP30 / 257106	HGNCID:	27414	Length:	1101	Species:	Homo sapiens

Alignment Length:	190	Identity:	48/190 - (25%)
Similarity:	86/190 - (45%)	Gaps:	34/190 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   394 IPALIVHCVNEIEARGLTEVGLYRLSSSEREYKALKEQFLRGKATPHLGNTDIYV--------LC 450
            :|.::..|...:|..|:.: |:||||......:.|:::| ..:..|.| ..|:|:        ||
Human    33 VPQVLKSCAEFVEEYGVVD-GIYRLSGVSSNIQKLRQEF-ESERKPDL-RRDVYLQDIHCVSSLC 94

  Fly   451 CCVKDFLRSLTEPLIPTSQWKDFANAVQNPDTKTAQDMLVK---SVKQLPQANRDTLAFLILHFQ 512
               |.:.|.|.:||:....:..||.||   ..:...:.|||   .:::||..|..||.||:.|..
Human    95 ---KAYFRELPDPLLTYRLYDKFAEAV---GVQLEPERLVKILEVLRELPVPNYRTLEFLMRHLV 153

  Fly   513 RIAQCPV-VLMPIDNISLIFGPTIV--------GYSTPDPDQHAIYTEVFTQKQVMKALL 563
            .:|.... ..|...|:::::.|.::        |::..     |.:.||..|..|::.:|
Human   154 HMASFSAQTNMHARNLAIVWAPNLLRSKDIEASGFNGT-----AAFMEVRVQSIVVEFIL 208

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tum	NP_610912.2	C1	319..367	CDD:237996
tum	NP_610912.2	RhoGAP_MgcRacGAP	381..570	CDD:239847	48/190 (25%)
ARHGAP30	NP_001020769.1	RhoGAP_CdGAP	16..210	CDD:239849	48/190 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	224..243
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	300..400
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	451..529
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	621..906
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	965..991
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1050..1101
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910