DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tum and ARHGAP45

DIOPT Version :9

Sequence 1:	NP_610912.2	Gene:	tum / 36538	FlyBaseID:	FBgn0086356	Length:	625	Species:	Drosophila melanogaster
Sequence 2:	XP_011526160.1	Gene:	ARHGAP45 / 23526	HGNCID:	17102	Length:	1168	Species:	Homo sapiens

Alignment Length:	683	Identity:	144/683 - (21%)
Similarity:	241/683 - (35%)	Gaps:	158/683 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 DLRRCMQVLTDGTPEEEFLRFLRMFEQYHEKCAGYAAETARIQNELDKSLTKMGDLEGKLFHARR 75
            :||:..|.......:.:..|||                .|:.:.|...|....|....|....||
Human   405 NLRKAKQGYVQRCEDHDKARFL----------------VAKAEEEQAGSAPGAGSTATKTLDKRR 453

  Fly    76 IIDMEIKARRQAEHERDAMESKIMAVADLLRHERNLNNETRDKLAFLHTLPSSRKRKSLNAVRED 140
            .::.|  |:.:||   :||.:....|||....::.|.:               .|..:|..::|.
Human   454 RLEEE--AKNKAE---EAMATYRTCVADAKTQKQELED---------------TKVTALRQIQEV 498

  Fly   141 KSYGDINSTGSLLSDLSITHSEDDFLDV------RTSK------SWREHRPSLPKNQIPSV---- 189
            ....|.....:.:|...:.|.:...|.|      .:||      .:..|...|.::|.|.|
Human   499 IRQSDQTIKSATISYYQMMHMQTAPLPVHFQMLCESSKLYDPGQQYASHVRQLQRDQEPDVHYDF 563

  Fly   190 --------------GNKRS-RLSTGLNGSMSGTTPTTGKSRRSSVGIGVEQHTVD--VGQGAERF 237
                          ..|.| .:|.......:|:.|..|   ..:.|...:.|..:  .|....|:
Human   564 EPHVSANAWSPVMRARKSSFNVSDVARPEAAGSPPEEG---GCTEGTPAKDHRGECPAGPRGGRW 625

  Fly   238 CATT------KVTIPQDGQG----------VIRAESTIESLPVIAGNERIGDGLSSTPRRSVLKE 286
            ...|      :..:...|:|          :..::|.::..|. ||:.:..:..||:...|..:|
Human   626 LPATHPGPSPETPLSPAGRGHQVHKSWPLSISDSDSGLDPGPG-AGDFKKFERTSSSGTMSSTEE 689

  Fly   287 ---------ATAPPLTPVNAMAPHV-VAESGTPLQHRPL---MRNHTFSQKTFLRGD-NCVQCQK 337
                     |:|.....:|.|.|.: ||....|.:|..|   .|.|...:   ||.. .|.:|..
Human   690 LVDPDGGAGASAFEQADLNGMTPELPVAVPSGPFRHEGLSKAARTHRLRK---LRTPAKCRECNS 751

  Fly   338 RIRFGAVGLRCRDCPVRCHIDCRYLLTVSCVPQTGTPTTKTMTG----YVTDF---APSIAPMIP 395
            .:.|  .|..|.:|.:.||..|...|.:.|       ..|.:.|    :..||   |.|....:|
Human   752 YVYF--QGAECEECCLACHKKCLETLAIQC-------GHKKLQGRLQLFGQDFSHAARSAPDGVP 807

  Fly   396 ALIVHCVNEIEARGLTEVGLYRLSSSEREYKALKEQFLRGKATPHLGNTDIYVLCCCVKDFLRSL 460
            .::..||.|||.|.|...|:||::..:...:.|.:.|..||....|.....:.:...:|.:||.|
Human   808 FIVKKCVCEIERRALRTKGIYRVNGVKTRVEKLCQAFENGKELVELSQASPHDISNVLKLYLRQL 872

  Fly   461 TEPLIPTSQWKDF---------ANAVQNPDTKTAQD-------------MLVKSVKQLPQANRDT 503
            .||||....:.:.         |.|.....::..||             .|.:.::.||..||.:
Human   873 PEPLISFRLYHELVGLAKDSLKAEAEAKAASRGRQDGSESEAVAVALAGRLRELLRDLPPENRAS 937

  Fly   504 LAFLILHFQRIAQCPV-VLMPIDNISLIFGPTIVGYSTPDPDQHAIYTEVFTQKQVMKALLELPV 567
            |.:|:.|.:||.:... ..|...|:.::||||::   .|.|.:..:.............::|..:
Human   938 LQYLLRHLRRIVEVEQDNKMTPGNLGIVFGPTLL---RPRPTEATVSLSSLVDYPHQARVIETLI 999

  Fly   568 SFWEQYIVIDPTRTP----------ATVIKRVP 590
            ..:......:|..||          |.|:.:||
Human  1000 VHYGLVFEEEPEETPGGQDESSNQRAEVVVQVP 1032

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tum	NP_610912.2	C1	319..367	CDD:237996	13/48 (27%)
tum	NP_610912.2	RhoGAP_MgcRacGAP	381..570	CDD:239847	52/218 (24%)
ARHGAP45	XP_011526160.1	FCH	285..360	CDD:214492
		C1	734..779	CDD:197519	13/49 (27%)
		RhoGAP	791..1001	CDD:295372	51/212 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910