DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tum and Myo9b

DIOPT Version :9

Sequence 1:	NP_610912.2	Gene:	tum / 36538	FlyBaseID:	FBgn0086356	Length:	625	Species:	Drosophila melanogaster
Sequence 2:	XP_006509629.1	Gene:	Myo9b / 17925	MGIID:	106624	Length:	2164	Species:	Mus musculus

Alignment Length:	633	Identity:	134/633 - (21%)
Similarity:	244/633 - (38%)	Gaps:	106/633 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 AAETARIQNELDKSLTKMGDLEGKLFHARRIIDMEIKARRQAEHERDAMESKIMAVADLLRHERN 110
            ||.|...:..:..|.:.:..|..........||.:..:::.:.|::.:.:......|.|....:.
Mouse  1361 AALTPTEERRISFSTSDVSKLSPVKVQTSAEIDGDFSSKKPSIHKKKSGDPSAGPDAGLSPGSQG 1425

  Fly   111 LNNETRDKLAFLHTLPSSRKRKSLNAVREDKSYGDINSTGSLLSDLSITHSEDDFLDVRTSKSWR 175
             ::::..|..|||  .:..|:.||..|.|.:|.|     |....:.....:    |||.:|:..|
Mouse  1426 -DSKSAFKRLFLH--KAKDKKPSLEGVEETESNG-----GQAAQETPARKT----LDVPSSQQHR 1478

  Fly   176 EHRPSLP----KNQIPSVG----NKRSR-------------------LSTGLNGSMSGTTPTTGK 213
            ......|    ||:...||    :::.|                   |...:|...|..||
Mouse  1479 HTTGEKPLKGKKNRNRKVGQITVSEKWRESVFRKITNANELKFLDEFLLNKVNDLRSQKTP---- 1539

  Fly   214 SRRSSVGIGVEQHTVDVGQGAERFCATTKV--TIPQDGQGVIRAESTIESLPVIAGNERIGDGLS 276
                     :|...:   :..|||.:..|.  ::| :|:..:..:..:|:..::..|.....|..
Mouse  1540 ---------IESLFI---EATERFRSNIKTMYSVP-NGKIHVGYKDLMENYQIVVSNLAAERGEK 1591

  Fly   277 STPR-----RSVLKEATAPPLTPVNAMAPHVVAESGTPLQHRPLMRN--HTFSQKTFLRGDNCVQ 334
            .|..     :|:|.|.|..........|....|:.....|.|.:..:  |.|:........:|.|
Mouse  1592 DTNLVLNVFQSLLDEFTRSYNKTDFERAKQSKAQKKKRKQERAVQEHNGHVFASYQVNIPQSCEQ 1656

  Fly   335 CQKRIRFGAVGLRCRDCPVRCHIDCRYLLTVSCVPQTGTPTTKTMT-----GYVTDFAPSIAPMI 394
            |...|......|.|..|.:.||..|.:.:...| ..||...::...     |...|...|....:
Mouse  1657 CLSYIWLMDKALLCSVCKMTCHKKCVHKIQSYC-SYTGRRKSELGAEPGHFGVCVDSLTSDKASV 1720

  Fly   395 PALIVHCVNEIEARGLTEVGLYRLSSSEREYKALKEQFLRGKATPHLGNTDIYVLCCCVKDFLRS 459
            |.::...:..:|..||...||||.|.:....:.|::......|...|.:..|:.:...:|.:||.
Mouse  1721 PIVLEKLLEHVEMHGLYTEGLYRKSGAANRTRELRQALQTDPAAVKLEDFPIHAITGVLKQWLRE 1785

  Fly   460 LTEPLIPTSQWKDFANAVQNPDTKTAQDMLVKSVKQLPQANRDTLAFLILHFQRIAQCPVVLMPI 524
            |.|||:..:|:.||..||:.|:.:.....:...:..||:||..:|..||.|..::|    :|..:
Mouse  1786 LPEPLMTFAQYGDFLRAVELPEKQEQLSAIYAVLDHLPEANHTSLERLIFHLVKVA----LLEDV 1846

  Fly   525 DNIS-----LIFGPTIVGYSTPD--------PDQHAIYT--EVFTQKQVMKALLELPVSFWEQYI 574
            :.:|     :||.|.::  ..||        .|...|.|  |:..::|:.|..:::     |:..
Mouse  1847 NRMSPGALAIIFAPCLL--RCPDNSDPLTSMKDVLKITTCVEMLIKEQMRKYKMKM-----EEIN 1904

  Fly   575 VIDPTRTPATVIKRVPSNKNDL---LSL-YATPFKGGTIKKRKFYGTP 618
            .::...:.|  .:|:...:.:.   |.| :::|::|..||..:   ||
Mouse  1905 HLEAAESIA--FRRLSLLRQNAPWPLKLGFSSPYEGVRIKSPR---TP 1947

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tum	NP_610912.2	C1	319..367	CDD:237996	12/47 (26%)
tum	NP_610912.2	RhoGAP_MgcRacGAP	381..570	CDD:239847	51/203 (25%)
Myo9b	XP_006509629.1	RA_Myosin-IXb	16..112	CDD:340737
		MYSc_Myo9	160..977	CDD:276836
		IQ	1014..1035	CDD:197470
		IQ	1036..1058	CDD:197470
		DUF4045	1207..>1495	CDD:372533	30/145 (21%)
		C1	1641..1689	CDD:237996	12/47 (26%)
		RhoGAP_myosin_IXB	1706..1891	CDD:239872	49/190 (26%)
		PHA02682	<2029..>2123	CDD:177464
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910