DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment tum and srgp-1

DIOPT Version :9

Sequence 1:NP_610912.2 Gene:tum / 36538 FlyBaseID:FBgn0086356 Length:625 Species:Drosophila melanogaster
Sequence 2:NP_001255566.1 Gene:srgp-1 / 178079 WormBaseID:WBGene00006406 Length:1059 Species:Caenorhabditis elegans


Alignment Length:532 Identity:96/532 - (18%)
Similarity:174/532 - (32%) Gaps:197/532 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly    53 QNELDKSLTKMGDLEGKLFHARRIIDMEIKARRQ----AEHE----------RDAMESKIMAV-- 101
            |:|:| ||..:..|..         .:::||.:|    |.|:          |..:...||.|  
 Worm   315 QHEMD-SLASLSTLRS---------SVDVKADKQKFFEANHQLFMLPKQFEFRPQLGDDIMEVSA 369

  Fly   102 -----ADLLRHERNLNNETR-DKLAFLHTLPSSRKRKSLNAVREDKSYGDINST------GSLLS 154
                 :|||  :|.|..|.| :.|.|    ......|||.|  .:|....:.:|      |...:
 Worm   370 EQSLSSDLL--QRQLQIEKRLEGLQF----EVDEVWKSLEA--SEKQLLQLYNTQFDGEAGKWRN 426

  Fly   155 DLSITHSE-----DDFLDVRTSKSWREHRPSLPKNQIPSVGNKRSRLSTGLNGSMSGTTPTTGKS 214
            ||.:|:..     :.||                                 |||::....    ::
 Worm   427 DLHVTYQYYLKKFEHFL---------------------------------LNGNLMERL----EA 454

  Fly   215 RRSSVGIGVEQHTVDVGQGAERFCATTKVTIPQDGQGVIRAESTIESLPVIAGNERIGDGLSSTP 279
            |.:|:|..:.:|.:                             :::|..|.:.:||.|.      
 Worm   455 RSASIGEALGKHGI-----------------------------SLKSASVGSASERNGS------ 484

  Fly   280 RRSVLKEATAPPLTPVNAMAPHVVAESGTPLQHRPLMRNHTFSQKTFLRGDNCVQCQKRIRFGAV 344
                                  ...|:|....|      |...::.          .|..|.|.:
 Worm   485 ----------------------FTTENGGSQNH------HLLEERR----------SKARRIGGI 511

  Fly   345 GLRCRDCPVRCHIDCRYLLTVSCVPQTGTPTTKTMTGYVTDFAPSIAPMIPALIVHCVNEIEARG 409
            ..:..|                     ..|..|...|.:.::..:....||.|:...:..:....
 Worm   512 VTKSPD---------------------DRPRPKLFGGSLDEYVEATGEEIPLLVQSAIAYLSRYS 555

  Fly   410 LTEVGLYRLSSSEREYKALKEQFLRGK-ATPHLGN-TDIYVLCCCVKDFLRSLTEPLIPTSQWKD 472
            |...||:|:|.|:.|....:|.:.||: ...:|.: :|.......:|.:.|.|.||:.|...::.
 Worm   556 LRNQGLFRVSGSQSEINRFREAYERGEDLFQYLDDGSDANSAAGVLKLYFRELREPIFPIFMFEQ 620

  Fly   473 FANAVQNPD----TKTAQDMLVKSVKQLPQANRDTLAFLILHFQRIAQ-CPVVLMPIDNISLIFG 532
            |.:..::..    .:.|:::    |.:||.::...|.||......:.: ....:|...|:::.||
 Worm   621 FCDCAKSESPTEFVRRAREL----VSKLPVSHVLLLRFLFAFLSHLCEFADENMMEPHNLAICFG 681

  Fly   533 PTIVGYSTPDPD 544
            ||::    |.|:
 Worm   682 PTLL----PIPE 689

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
tumNP_610912.2 C1 319..367 CDD:237996 5/47 (11%)
RhoGAP_MgcRacGAP 381..570 CDD:239847 38/171 (22%)
srgp-1NP_001255566.1 F-BAR_srGAP 60..300 CDD:153340
RhoGAP 523..710 CDD:383032 39/175 (22%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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