DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tum and cyk-4

DIOPT Version :9

Sequence 1:	NP_610912.2	Gene:	tum / 36538	FlyBaseID:	FBgn0086356	Length:	625	Species:	Drosophila melanogaster
Sequence 2:	NP_499845.1	Gene:	cyk-4 / 176815	WormBaseID:	WBGene00000875	Length:	681	Species:	Caenorhabditis elegans

Alignment Length:	692	Identity:	169/692 - (24%)
Similarity:	273/692 - (39%)	Gaps:	155/692 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 EEFLRFLRMFEQYHEKCAGYAAETARIQNELDKSLTKMG----DLEGKLFHARRI--------ID 78
            :|..|..::::...|......|:....:..|.|:..|:.    |::....|.|.:        :|
Worm    42 DEIERLRKLWKDSEESKKRLNADMREAEEALAKARKKLAMFDIDVKDTQKHLRALMEENKALKLD 106

  Fly    79 MEIKARRQAEHERDAMESKIMAVADLLRHERNLNNETRDKLAFLH-----TLPSSRKRKSLNAVR 138
            :.:...|: :..:|||::.|.         .:|..|.||:..|||     |.....:::..:.:.
Worm   107 LNVYETRE-KQLKDAMKNGIF---------NSLTKEDRDQFKFLHEPLVRTYSKRVQQRHPHLME 161

  Fly   139 -----EDKSYGDINSTGSLLSDLSITHSEDDFLDVRTSKSWREHRPSLPKNQIPSVGNKRSRLST 198
                 ||.|..|.:.||            |.|.:|...::.||.|.|.....  :||.||...|
Worm   162 DTQDDEDDSEVDYDETG------------DSFEEVIHLRNGREVRRSSAAGN--AVGGKRRSAS- 211

  Fly   199 GLNGSMSGTTPTTGKSRRSSVGIGVEQHTVDVGQGAERFC----------------ATTKVTI-- 245
                :.:.|.....|..||.|.........:.|....:.|                .||..||
Worm   212 ----AHAITAAANSKRSRSRVMTATIDEEPNEGGTPPKRCRDDGSTPHQEMTTTTTTTTTTTIHN 272

  Fly   246 ----PQDGQGV------IRAESTIESLPVI-----AGNERIGDGLSSTPRRSVLKEATAPPLTPV 295
                .||...|      .|...:..|:|..     .....||.|:||    ::|.::|....|
Worm   273 SRAQNQDPPRVSLHRQLTRRSLSCGSIPSCDQTPGQTTNNIGLGMSS----AILTKSTLDIRT-- 331

  Fly   296 NAMAPHVVAESGTPL----QHRPL-MRNHTFSQKTFLRGDNCVQCQKRIRFGAVGLRCRDCPVRC 355
                    .:.|||.    ..|.: ||.|||.:........|.:|...::. |..::||||....
Worm   332 --------LKRGTPAWTNGTTRDIAMRPHTFIEAGIKAMRKCDKCATALKL-ATSMKCRDCHQVV 387

  Fly   356 HIDCRYLLTVSCVPQTGTPTT--------KTMTG--YVTDFAPSIAPMIPALIVHCVNEIEARGL 410
            |..|...|.:.|:|:..|..|        |...|  .:.||..|..|||||.::|||..:|||||
Worm   388 HRSCCNKLHLPCIPRPKTMMTPKSALRGAKPGAGEFRLQDFCTSAKPMIPAAVIHCVVALEARGL 452

  Fly   411 TEVGLYRLSSSEREYKALKEQFLRGKATPHLGNTDIYVLCCCVKDFLRSLTEPLIPTSQWKDF-- 473
            |:.|:||:....|....|.:: ||.|..|::|..|:.|:...:|.|||.|.:||||.:..::.
Worm   453 TQEGIYRVPGQVRTVNVLLDE-LRSKTVPNVGLHDVEVITDTLKRFLRDLKDPLIPRTSRQELIV 516

  Fly   474 ANAVQNPDTKTAQDMLVKSVKQLPQANRDTLAFLILHFQR-IAQCPVVLMPIDNISLIFGPTIVG 537
            |..:.:.|....:..|.:.:.:||||||||||:|.:|::: |||.....|..:.::.:..|.::|
Worm   517 AANLYSTDPDNGRLALNRVICELPQANRDTLAYLFIHWRKVIAQSSRNKMNCEAMARMVAPAVMG 581

  Fly   538 YSTPDPDQHAIYTEVFTQ-KQVMKALLELPVSFWEQYI--------------------------- 574
            :........||.....|. .:.|.||.|....:|::::
Worm   582 HPVKQSQSQAIAGRDATDCHRAMTALFEFDDVYWQRFLGTSAVSMASNQIETARHQDNFALCDRS 646

  Fly   575 VIDP-TRTPATVIKRVPSNKNDLLSLYATPFKGGTIKKRKFY 615
            ::.| |.:|||.:....:|        ||..:|..:....|:
Worm   647 ILGPVTTSPATPLLARSAN--------ATRARGAHLLGSMFH 680

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tum	NP_610912.2	C1	319..367	CDD:237996	13/47 (28%)
tum	NP_610912.2	RhoGAP_MgcRacGAP	381..570	CDD:239847	67/194 (35%)
cyk-4	NP_499845.1	DUF5098	33..>184	CDD:293628	32/163 (20%)
		C1	352..402	CDD:294036	14/50 (28%)
		RhoGAP_MgcRacGAP	418..615	CDD:239847	67/197 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160159176
Domainoid	1	1.000	94	1.000	Domainoid score	I4704
eggNOG	1	0.900	-	-		E1_KOG3564
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0.928771	Normalized mean entropy	S4674
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D184774at33208
OrthoFinder	1	1.000	-	-		FOG0004815
OrthoInspector	1	1.000	-	-		otm14660
orthoMCL	1	0.900	-	-		OOG6_106233
Panther	1	1.100	-	-	LDO	PTHR46199
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4412
SonicParanoid	1	1.000	-	-		X3396
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	13.730